Increased frequency (12%) of circulating chronic lymphocytic leukemia-like B-cell clones in healthy subjects using a highly sensitive multicolor flow cytometry approach

Monoclonal B-cell lymphocytosis (MBL) indicates the presence of less than 5 x 10(9)/L circulating monoclonal B cells in otherwise healthy subjects. Recently, it has been reported that circulating chronic lymphocytic leukemia (CLL)-like B cells can be detected using 4- or 5-multicolor flow cytometry...

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Bibliographic Details
Published in:	Blood Vol. 114; no. 1; p. 33
Main Authors:	Nieto, Wendy G, Almeida, Julia, Romero, Alfonso, Teodosio, Cristina, López, Antonio, Henriques, Ana F, Sánchez, Maria Luz, Jara-Acevedo, María, Rasillo, Ana, González, Marcos, Fernández-Navarro, Paulino, Vega, Tomás, Orfao, Alberto
Format:	Journal Article
Language:	English
Published:	United States 02.07.2009
Subjects:	Adult Aged Aged, 80 and over B-Lymphocytes - immunology B-Lymphocytes - pathology Diagnosis, Differential Disease Progression Female Flow Cytometry - methods Flow Cytometry - statistics & numerical data Gene Rearrangement, B-Lymphocyte, Heavy Chain Humans Immunophenotyping Leukemia, Lymphocytic, Chronic, B-Cell - blood Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - immunology Lymphocyte Count Lymphocytosis - blood Lymphocytosis - diagnosis Lymphocytosis - genetics Lymphocytosis - immunology Male Middle Aged Precancerous Conditions - blood Precancerous Conditions - diagnosis Precancerous Conditions - genetics Precancerous Conditions - immunology Sensitivity and Specificity
ISSN:	1528-0020, 1528-0020
Online Access:	Get more information
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