NDR2 promotes the antiviral immune response via facilitating TRIM25-mediated RIG-I activation in macrophages

NDR2 functions as an antiviral molecule via regulating TRIM25-mediated RIG-I activation. Retinoic acid–inducible gene I (RIG-I), a pivotal cytosolic sensor, recognizes viral RNAs to initiate antiviral innate immunity. However, posttranslational regulation of RIG-I signaling is not well understood. W...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Science advances Jg. 5; H. 2; S. eaav0163
Hauptverfasser:	Liu, Zhiyong, Wu, Cheng, Pan, Yueyun, Liu, Huan, Wang, Xiumei, Yang, Yuting, Gu, Meidi, Zhang, Yuanyuan, Wang, Xiaojian
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States American Association for the Advancement of Science 01.02.2019
Schlagworte:	Animals Biomarkers Cytokines DEAD Box Protein 58 - metabolism Disease Models, Animal Enzyme Activation Host-Pathogen Interactions - immunology Humans Immunity Immunology Immunomodulation Macrophages - immunology Macrophages - metabolism Macrophages - virology Mice Mice, Knockout Protein Serine-Threonine Kinases - metabolism Receptors, Immunologic SciAdv r-articles Signal Transduction Transcription Factors - metabolism Tripartite Motif Proteins - metabolism Ubiquitin-Protein Ligases - metabolism Ubiquitination Virus Diseases - immunology Virus Diseases - metabolism Virus Diseases - virology
ISSN:	2375-2548, 2375-2548
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!