Phase separation of Polycomb-repressive complex 1 is governed by a charged disordered region of CBX2

Mammalian development requires effective mechanisms to repress genes whose expression would generate inappropriately specified cells. The Polycomb-repressive complex 1 (PRC1) family complexes are central to maintaining this repression. These include a set of canonical PRC1 complexes, each of which c...

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Bibliographic Details
Published in:	Genes & development Vol. 33; no. 13-14; p. 799
Main Authors:	Plys, Aaron J, Davis, Christopher P, Kim, Jongmin, Rizki, Gizem, Keenen, Madeline M, Marr, Sharon K, Kingston, Robert E
Format:	Journal Article
Language:	English
Published:	United States 01.07.2019
Subjects:	Animals Cell Line Escherichia coli - genetics Gene Expression Regulation, Developmental - genetics Mice Mice, Inbred C57BL NIH 3T3 Cells Organelles - metabolism Point Mutation Polycomb Repressive Complex 1 - chemistry Polycomb Repressive Complex 1 - genetics Polycomb Repressive Complex 1 - metabolism Protein Domains Sf9 Cells gene repression development phase separation PRC1 Polycomb-repressive complex nucleosome compaction chromatin
ISSN:	1549-5477, 1549-5477
Online Access:	Get more information
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