Neuroinvasive arboviral disease in the United States: 2003 to 2012

To describe the epidemiologic and clinical syndromes associated with pediatric neuroinvasive arboviral infections among children in the United States from 2003 through 2012. We reviewed data reported by state health departments to ArboNET, the national arboviral surveillance system, for 2003 through...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Pediatrics (Evanston) Ročník 134; číslo 3; s. e642
Hlavní autori:	Gaensbauer, James T, Lindsey, Nicole P, Messacar, Kevin, Staples, J Erin, Fischer, Marc
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.09.2014
Predmet:	Arbovirus Infections - diagnosis Arbovirus Infections - epidemiology Arbovirus Infections - virology Child Encephalitis, California - diagnosis Encephalitis, California - epidemiology Encephalitis, California - virology Humans La Crosse virus - pathogenicity Population Surveillance - methods United States - epidemiology West Nile Fever - diagnosis West Nile Fever - epidemiology West Nile Fever - virology United States epidemiology United States arboviruses child
ISSN:	1098-4275, 1098-4275
On-line prístup:	Zistit podrobnosti o prístupe
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Abstract	To describe the epidemiologic and clinical syndromes associated with pediatric neuroinvasive arboviral infections among children in the United States from 2003 through 2012. We reviewed data reported by state health departments to ArboNET, the national arboviral surveillance system, for 2003 through 2012. Children (<18 years) with neuroinvasive arboviral infections (eg, meningitis, encephalitis, or acute flaccid paralysis) were included. Demographic, clinical syndrome, outcome, geographic, and temporal data were analyzed for all cases. During the study period, 1217 cases and 22 deaths due to pediatric neuroinvasive arboviral infection were reported from the 48 contiguous states. La Crosse virus (665 cases; 55%) and West Nile virus (505 cases; 41%) were the most common etiologies identified. Although less common, Eastern equine encephalitis virus (30 cases; 2%) resulted in 10 pediatric deaths. La Crosse virus primarily affected younger children, whereas West Nile virus was more common in older children and adolescents. West Nile virus disease cases occurred throughout the country, whereas La Crosse and the other arboviruses were more focally distributed. Neuroinvasive arboviral infections were an important cause of pediatric disease from 2003 through 2012. Differences in the epidemiology and clinical disease result from complex interactions among virus, vector, host, and the environment. Decreasing the morbidity and mortality from these agents depends on vector control, personal protection to reduce mosquito and tick bites, and blood donor screening. Effective surveillance is critical to inform clinicians and public health officials about the epidemiologic features of these diseases and to direct prevention efforts.
AbstractList	To describe the epidemiologic and clinical syndromes associated with pediatric neuroinvasive arboviral infections among children in the United States from 2003 through 2012. We reviewed data reported by state health departments to ArboNET, the national arboviral surveillance system, for 2003 through 2012. Children (<18 years) with neuroinvasive arboviral infections (eg, meningitis, encephalitis, or acute flaccid paralysis) were included. Demographic, clinical syndrome, outcome, geographic, and temporal data were analyzed for all cases. During the study period, 1217 cases and 22 deaths due to pediatric neuroinvasive arboviral infection were reported from the 48 contiguous states. La Crosse virus (665 cases; 55%) and West Nile virus (505 cases; 41%) were the most common etiologies identified. Although less common, Eastern equine encephalitis virus (30 cases; 2%) resulted in 10 pediatric deaths. La Crosse virus primarily affected younger children, whereas West Nile virus was more common in older children and adolescents. West Nile virus disease cases occurred throughout the country, whereas La Crosse and the other arboviruses were more focally distributed. Neuroinvasive arboviral infections were an important cause of pediatric disease from 2003 through 2012. Differences in the epidemiology and clinical disease result from complex interactions among virus, vector, host, and the environment. Decreasing the morbidity and mortality from these agents depends on vector control, personal protection to reduce mosquito and tick bites, and blood donor screening. Effective surveillance is critical to inform clinicians and public health officials about the epidemiologic features of these diseases and to direct prevention efforts. To describe the epidemiologic and clinical syndromes associated with pediatric neuroinvasive arboviral infections among children in the United States from 2003 through 2012.OBJECTIVETo describe the epidemiologic and clinical syndromes associated with pediatric neuroinvasive arboviral infections among children in the United States from 2003 through 2012.We reviewed data reported by state health departments to ArboNET, the national arboviral surveillance system, for 2003 through 2012. Children (<18 years) with neuroinvasive arboviral infections (eg, meningitis, encephalitis, or acute flaccid paralysis) were included. Demographic, clinical syndrome, outcome, geographic, and temporal data were analyzed for all cases.METHODSWe reviewed data reported by state health departments to ArboNET, the national arboviral surveillance system, for 2003 through 2012. Children (<18 years) with neuroinvasive arboviral infections (eg, meningitis, encephalitis, or acute flaccid paralysis) were included. Demographic, clinical syndrome, outcome, geographic, and temporal data were analyzed for all cases.During the study period, 1217 cases and 22 deaths due to pediatric neuroinvasive arboviral infection were reported from the 48 contiguous states. La Crosse virus (665 cases; 55%) and West Nile virus (505 cases; 41%) were the most common etiologies identified. Although less common, Eastern equine encephalitis virus (30 cases; 2%) resulted in 10 pediatric deaths. La Crosse virus primarily affected younger children, whereas West Nile virus was more common in older children and adolescents. West Nile virus disease cases occurred throughout the country, whereas La Crosse and the other arboviruses were more focally distributed.RESULTSDuring the study period, 1217 cases and 22 deaths due to pediatric neuroinvasive arboviral infection were reported from the 48 contiguous states. La Crosse virus (665 cases; 55%) and West Nile virus (505 cases; 41%) were the most common etiologies identified. Although less common, Eastern equine encephalitis virus (30 cases; 2%) resulted in 10 pediatric deaths. La Crosse virus primarily affected younger children, whereas West Nile virus was more common in older children and adolescents. West Nile virus disease cases occurred throughout the country, whereas La Crosse and the other arboviruses were more focally distributed.Neuroinvasive arboviral infections were an important cause of pediatric disease from 2003 through 2012. Differences in the epidemiology and clinical disease result from complex interactions among virus, vector, host, and the environment. Decreasing the morbidity and mortality from these agents depends on vector control, personal protection to reduce mosquito and tick bites, and blood donor screening. Effective surveillance is critical to inform clinicians and public health officials about the epidemiologic features of these diseases and to direct prevention efforts.CONCLUSIONSNeuroinvasive arboviral infections were an important cause of pediatric disease from 2003 through 2012. Differences in the epidemiology and clinical disease result from complex interactions among virus, vector, host, and the environment. Decreasing the morbidity and mortality from these agents depends on vector control, personal protection to reduce mosquito and tick bites, and blood donor screening. Effective surveillance is critical to inform clinicians and public health officials about the epidemiologic features of these diseases and to direct prevention efforts.
Author	Fischer, Marc Gaensbauer, James T Messacar, Kevin Lindsey, Nicole P Staples, J Erin
Author_xml	– sequence: 1 givenname: James T surname: Gaensbauer fullname: Gaensbauer, James T organization: Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado; and – sequence: 2 givenname: Nicole P surname: Lindsey fullname: Lindsey, Nicole P organization: Arboviral Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado – sequence: 3 givenname: Kevin surname: Messacar fullname: Messacar, Kevin organization: Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado; and – sequence: 4 givenname: J Erin surname: Staples fullname: Staples, J Erin organization: Arboviral Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado – sequence: 5 givenname: Marc surname: Fischer fullname: Fischer, Marc email: mfischer@cdc.gov organization: Arboviral Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado mfischer@cdc.gov
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/25113294$$D View this record in MEDLINE/PubMed
BookMark	eNpNj0tLw0AURgep2FrdupRZukm9czOPjDstvqDoQrsOk8kNjqRJzUwK_nsLVnB1vsXhwHfKJl3fEWMXAhZCSbzeUh0XCEJmIG1xxGYCbJFJNGryb0_ZaYyfACCVwRM2RSVEjlbO2N0LjUMfup2LYUfcDVW_C4NreR0iuUg8dDx9EF93IVHN35JLFG84AuQ89XsKPGPHjWsjnR84Z-uH-_flU7Z6fXxe3q4yL5VOmaWKhEL0znssdN4IqHXhwSqlCjLSGw3WeSJttCXXWJcLr7ECDVS7BnDOrn6726H_GimmchOip7Z1HfVjLIXSsK8Zo_bq5UEdqw3V5XYIGzd8l3-_8QdZy1ne
CitedBy_id	crossref_primary_10_1111_jvec_12326 crossref_primary_10_3390_v16050787 crossref_primary_10_1111_ajt_15589 crossref_primary_10_3390_ijms252413318 crossref_primary_10_3201_eid2209_152050 crossref_primary_10_3390_children8090782 crossref_primary_10_1136_pmj_2022_142002 crossref_primary_10_1093_ofid_ofv190 crossref_primary_10_1128_jvi_00300_24 crossref_primary_10_1111_bpa_12280 crossref_primary_10_15585_mmwr_mm6453a1 crossref_primary_10_1111_petr_12710 crossref_primary_10_1093_cid_ciaa749 crossref_primary_10_1093_infdis_jiaf182 crossref_primary_10_1016_j_idc_2017_10_007 crossref_primary_10_1038_s41390_023_02866_x crossref_primary_10_15585_mmwr_mm6739a8 crossref_primary_10_15585_mmwr_mm6831a1 crossref_primary_10_1186_s13052_018_0574_x crossref_primary_10_3390_v11090794 crossref_primary_10_1002_cpt_75 crossref_primary_10_1093_cid_ciac403 crossref_primary_10_1186_s12985_017_0687_7 crossref_primary_10_3389_fneur_2018_00082 crossref_primary_10_3389_fped_2022_923125 crossref_primary_10_1093_jme_tjad090 crossref_primary_10_1186_s12974_018_1356_5 crossref_primary_10_1093_jme_tjab079 crossref_primary_10_1371_journal_pntd_0011065 crossref_primary_10_1177_0009922818806842 crossref_primary_10_1007_s40124_015_0089_5 crossref_primary_10_1016_j_antiviral_2020_104875 crossref_primary_10_1016_j_pediatrneurol_2017_11_013 crossref_primary_10_15585_mmwr_mm6741a1 crossref_primary_10_3390_v11030303 crossref_primary_10_1093_jnen_nlaa094 crossref_primary_10_15585_mmwr_mm6701a3 crossref_primary_10_1186_s12889_022_14792_4 crossref_primary_10_1089_vbz_2023_0109 crossref_primary_10_3390_pathogens10080998 crossref_primary_10_1212_WNL_0000000000002234 crossref_primary_10_1080_23744235_2024_2403712 crossref_primary_10_1007_s00112_022_01610_9 crossref_primary_10_1007_s13365_020_00913_5 crossref_primary_10_1016_S0140_6736_14_62457_0 crossref_primary_10_1128_JVI_02134_19 crossref_primary_10_1371_journal_pntd_0009494 crossref_primary_10_1016_j_pediatrneurol_2023_09_020 crossref_primary_10_1371_journal_pntd_0012186 crossref_primary_10_3390_pathogens11050501 crossref_primary_10_1016_j_coi_2015_10_008 crossref_primary_10_1586_14787210_2015_1083859 crossref_primary_10_1007_s00401_015_1433_0 crossref_primary_10_1093_jpids_piv072 crossref_primary_10_1186_s12879_017_2637_9 crossref_primary_10_1017_S0950268818003096 crossref_primary_10_1093_jme_tjy190 crossref_primary_10_1080_14787210_2016_1215914 crossref_primary_10_3390_tropicalmed5020096 crossref_primary_10_1097_INF_0000000000002856 crossref_primary_10_3390_idr15040036 crossref_primary_10_1155_2020_3513859 crossref_primary_10_4049_jimmunol_1701230 crossref_primary_10_1542_peds_2015_3233 crossref_primary_10_1097_QCO_0000000000001042 crossref_primary_10_1016_j_jiph_2017_07_003 crossref_primary_10_1371_journal_ppat_1012574 crossref_primary_10_3201_eid2401_170545 crossref_primary_10_3390_ijms25052598 crossref_primary_10_52707_1081_1710_49_2_R27 crossref_primary_10_1371_journal_pone_0237322 crossref_primary_10_52707_1081_1710_46_1_34 crossref_primary_10_1016_j_spen_2025_101208 crossref_primary_10_1186_s12985_025_02720_y crossref_primary_10_3389_fmicb_2023_1159835 crossref_primary_10_15585_mmwr_mm7032a1 crossref_primary_10_3201_eid2504_181016 crossref_primary_10_3389_finsc_2022_1073308 crossref_primary_10_1542_pir_2016_0227 crossref_primary_10_1542_pir_2018_0175 crossref_primary_10_1016_j_pediatrneurol_2018_07_019 crossref_primary_10_1371_journal_pone_0249811 crossref_primary_10_18043_001c_118585
ContentType	Journal Article
Copyright	Copyright © 2014 by the American Academy of Pediatrics.
Copyright_xml	– notice: Copyright © 2014 by the American Academy of Pediatrics.
DBID	CGR CUY CVF ECM EIF NPM 7X8
DOI	10.1542/peds.2014-0498
DatabaseName	Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic
DatabaseTitle	MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic
DatabaseTitleList	MEDLINE MEDLINE - Academic
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	no_fulltext_linktorsrc
Discipline	Medicine
EISSN	1098-4275
ExternalDocumentID	25113294
Genre	Research Support, U.S. Gov't, P.H.S Journal Article Review
GeographicLocations	United States
GeographicLocations_xml	– name: United States
GrantInformation_xml	– fundername: Intramural CDC HHS grantid: CC999999
GroupedDBID	--- -ET ..I .55 .GJ 0R~ 123 18M 1CY 1HT 26- 29O 2KS 2QL 2WC 36B 39C 4.4 41~ 53G 5RE 5VS 6PF 7K8 85S 8F7 8GL 96U AAAMJ AAHTB AAIKC AAJMC AAKAS AAMNW AAQOH AAWTL AAWTO ABCZD ABIVO ABJNI ABOCM ABPEJ ABPPZ ACBMB ACGFO ACGOD ACNCT ACPRK ADCOW ADZCM AENEX AFAZI AFFNX AFHKK AFOSN AFRAH AHMBA AJUXI ALMA_UNASSIGNED_HOLDINGS BKOMP CGR CS3 CUY CVF DIK DU5 E3Z EBS ECM EIF EJD EX3 F5P F8P FEDTE GICCO GOZPB GX1 H13 HF~ HVGLF IAG IAO ICJ IEA IER IHR IMI INH INR IOF IPO IPY ISE ITC IVC KO8 KQ8 L7B LXL LXN LXY N4W N9A NEJ NPM OHT OK1 OMK OVD P0W P2P PDE PQQKQ Q.- RHI SJN TAE TEORI TR2 TWZ UBE UHB UMD W8F WH7 WHG WOQ WOW WQ9 X7M XJT XOL XZL YHG YHZ YOC YQI YQJ YZZ ZGI ZRR ZXP ~KM ~X8 7X8
ID	FETCH-LOGICAL-c456t-9ebe1522cacc2863f10d68c095558e74c7609acee6769eaf9a31c62b060edaf02
IEDL.DBID	7X8
ISICitedReferencesCount	87
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000341362600002&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1098-4275
IngestDate	Fri Sep 05 11:29:58 EDT 2025 Mon Jul 21 06:02:52 EDT 2025
IsDoiOpenAccess	false
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	3
Keywords	epidemiology United States arboviruses child
Language	English
License	Copyright © 2014 by the American Academy of Pediatrics.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c456t-9ebe1522cacc2863f10d68c095558e74c7609acee6769eaf9a31c62b060edaf02
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
OpenAccessLink	https://pediatrics.aappublications.org/content/pediatrics/134/3/e642.full.pdf
PMID	25113294
PQID	1560095775
PQPubID	23479
ParticipantIDs	proquest_miscellaneous_1560095775 pubmed_primary_25113294
PublicationCentury	2000
PublicationDate	2014-09-01
PublicationDateYYYYMMDD	2014-09-01
PublicationDate_xml	– month: 09 year: 2014 text: 2014-09-01 day: 01
PublicationDecade	2010
PublicationPlace	United States
PublicationPlace_xml	– name: United States
PublicationTitle	Pediatrics (Evanston)
PublicationTitleAlternate	Pediatrics
PublicationYear	2014
SSID	ssj0004572
Score	2.473797
SecondaryResourceType	review_article
Snippet	To describe the epidemiologic and clinical syndromes associated with pediatric neuroinvasive arboviral infections among children in the United States from 2003...
SourceID	proquest pubmed
SourceType	Aggregation Database Index Database
StartPage	e642
SubjectTerms	Arbovirus Infections - diagnosis Arbovirus Infections - epidemiology Arbovirus Infections - virology Child Encephalitis, California - diagnosis Encephalitis, California - epidemiology Encephalitis, California - virology Humans La Crosse virus - pathogenicity Population Surveillance - methods United States - epidemiology West Nile Fever - diagnosis West Nile Fever - epidemiology West Nile Fever - virology
Title	Neuroinvasive arboviral disease in the United States: 2003 to 2012
URI	https://www.ncbi.nlm.nih.gov/pubmed/25113294 https://www.proquest.com/docview/1560095775
Volume	134
WOSCitedRecordID	wos000341362600002&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText
inHoldings	1
isFullTextHit
isPrint
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LSwMxEB7Uinjx_agvIngN7ia7m8SLqFi8tPSg0FvJa6Egu7Wt_f1mdlP0Ighedk8Ly2Qy8yXfNzMANy6cqsqsVFQLLMkxzlCdC00dz40xvEAmrxk2IQYDORqpYbxwm0dZ5SomNoHa1RbvyG-x4jfAASHy--kHxalRyK7GERrr0OEByqBXi9HPbuGiZTuVpBkTeWzamGfsduodNutOUYWh5O_wskkzvd3__uAe7ESASR5aj9iHNV8dwFY_UuiH8Ni045hUS43CdaJnpkad7zuJVA2ZVCSAQtKCUdKC0TuC6jKyqMM7ZUfw1nt-fXqhcZACtQEfLagKKxXyNLPaWiYLXqaJK6TF7nO59CKzokiUDukS9a5el0rz1BbMJEXinS4TdgwbVV35UyAysSkWfgQYmGfcGmUL6UJQMIJbrMntwvXKOuPgqMg-6MrXn_Pxt326cNKaeDxtO2qM8ZzDmcrO_vD1OWy364Y6rwvolGGb-kvYtMvFZD67ajwgPAfD_hcmvbhc
linkProvider	ProQuest
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Neuroinvasive+arboviral+disease+in+the+United+States%3A+2003+to+2012&rft.jtitle=Pediatrics+%28Evanston%29&rft.au=Gaensbauer%2C+James+T&rft.au=Lindsey%2C+Nicole+P&rft.au=Messacar%2C+Kevin&rft.au=Staples%2C+J+Erin&rft.date=2014-09-01&rft.issn=1098-4275&rft.eissn=1098-4275&rft.volume=134&rft.issue=3&rft.spage=e642&rft_id=info:doi/10.1542%2Fpeds.2014-0498&rft.externalDBID=NO_FULL_TEXT
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1098-4275&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1098-4275&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1098-4275&client=summon