Neuroinvasive arboviral disease in the United States: 2003 to 2012

To describe the epidemiologic and clinical syndromes associated with pediatric neuroinvasive arboviral infections among children in the United States from 2003 through 2012. We reviewed data reported by state health departments to ArboNET, the national arboviral surveillance system, for 2003 through...

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Veröffentlicht in:	Pediatrics (Evanston) Jg. 134; H. 3; S. e642
Hauptverfasser:	Gaensbauer, James T, Lindsey, Nicole P, Messacar, Kevin, Staples, J Erin, Fischer, Marc
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.09.2014
Schlagworte:	Arbovirus Infections - diagnosis Arbovirus Infections - epidemiology Arbovirus Infections - virology Child Encephalitis, California - diagnosis Encephalitis, California - epidemiology Encephalitis, California - virology Humans La Crosse virus - pathogenicity Population Surveillance - methods United States - epidemiology West Nile Fever - diagnosis West Nile Fever - epidemiology West Nile Fever - virology United States epidemiology United States arboviruses child
ISSN:	1098-4275, 1098-4275
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Abstract	To describe the epidemiologic and clinical syndromes associated with pediatric neuroinvasive arboviral infections among children in the United States from 2003 through 2012. We reviewed data reported by state health departments to ArboNET, the national arboviral surveillance system, for 2003 through 2012. Children (<18 years) with neuroinvasive arboviral infections (eg, meningitis, encephalitis, or acute flaccid paralysis) were included. Demographic, clinical syndrome, outcome, geographic, and temporal data were analyzed for all cases. During the study period, 1217 cases and 22 deaths due to pediatric neuroinvasive arboviral infection were reported from the 48 contiguous states. La Crosse virus (665 cases; 55%) and West Nile virus (505 cases; 41%) were the most common etiologies identified. Although less common, Eastern equine encephalitis virus (30 cases; 2%) resulted in 10 pediatric deaths. La Crosse virus primarily affected younger children, whereas West Nile virus was more common in older children and adolescents. West Nile virus disease cases occurred throughout the country, whereas La Crosse and the other arboviruses were more focally distributed. Neuroinvasive arboviral infections were an important cause of pediatric disease from 2003 through 2012. Differences in the epidemiology and clinical disease result from complex interactions among virus, vector, host, and the environment. Decreasing the morbidity and mortality from these agents depends on vector control, personal protection to reduce mosquito and tick bites, and blood donor screening. Effective surveillance is critical to inform clinicians and public health officials about the epidemiologic features of these diseases and to direct prevention efforts.
AbstractList	To describe the epidemiologic and clinical syndromes associated with pediatric neuroinvasive arboviral infections among children in the United States from 2003 through 2012. We reviewed data reported by state health departments to ArboNET, the national arboviral surveillance system, for 2003 through 2012. Children (<18 years) with neuroinvasive arboviral infections (eg, meningitis, encephalitis, or acute flaccid paralysis) were included. Demographic, clinical syndrome, outcome, geographic, and temporal data were analyzed for all cases. During the study period, 1217 cases and 22 deaths due to pediatric neuroinvasive arboviral infection were reported from the 48 contiguous states. La Crosse virus (665 cases; 55%) and West Nile virus (505 cases; 41%) were the most common etiologies identified. Although less common, Eastern equine encephalitis virus (30 cases; 2%) resulted in 10 pediatric deaths. La Crosse virus primarily affected younger children, whereas West Nile virus was more common in older children and adolescents. West Nile virus disease cases occurred throughout the country, whereas La Crosse and the other arboviruses were more focally distributed. Neuroinvasive arboviral infections were an important cause of pediatric disease from 2003 through 2012. Differences in the epidemiology and clinical disease result from complex interactions among virus, vector, host, and the environment. Decreasing the morbidity and mortality from these agents depends on vector control, personal protection to reduce mosquito and tick bites, and blood donor screening. Effective surveillance is critical to inform clinicians and public health officials about the epidemiologic features of these diseases and to direct prevention efforts. To describe the epidemiologic and clinical syndromes associated with pediatric neuroinvasive arboviral infections among children in the United States from 2003 through 2012.OBJECTIVETo describe the epidemiologic and clinical syndromes associated with pediatric neuroinvasive arboviral infections among children in the United States from 2003 through 2012.We reviewed data reported by state health departments to ArboNET, the national arboviral surveillance system, for 2003 through 2012. Children (<18 years) with neuroinvasive arboviral infections (eg, meningitis, encephalitis, or acute flaccid paralysis) were included. Demographic, clinical syndrome, outcome, geographic, and temporal data were analyzed for all cases.METHODSWe reviewed data reported by state health departments to ArboNET, the national arboviral surveillance system, for 2003 through 2012. Children (<18 years) with neuroinvasive arboviral infections (eg, meningitis, encephalitis, or acute flaccid paralysis) were included. Demographic, clinical syndrome, outcome, geographic, and temporal data were analyzed for all cases.During the study period, 1217 cases and 22 deaths due to pediatric neuroinvasive arboviral infection were reported from the 48 contiguous states. La Crosse virus (665 cases; 55%) and West Nile virus (505 cases; 41%) were the most common etiologies identified. Although less common, Eastern equine encephalitis virus (30 cases; 2%) resulted in 10 pediatric deaths. La Crosse virus primarily affected younger children, whereas West Nile virus was more common in older children and adolescents. West Nile virus disease cases occurred throughout the country, whereas La Crosse and the other arboviruses were more focally distributed.RESULTSDuring the study period, 1217 cases and 22 deaths due to pediatric neuroinvasive arboviral infection were reported from the 48 contiguous states. La Crosse virus (665 cases; 55%) and West Nile virus (505 cases; 41%) were the most common etiologies identified. Although less common, Eastern equine encephalitis virus (30 cases; 2%) resulted in 10 pediatric deaths. La Crosse virus primarily affected younger children, whereas West Nile virus was more common in older children and adolescents. West Nile virus disease cases occurred throughout the country, whereas La Crosse and the other arboviruses were more focally distributed.Neuroinvasive arboviral infections were an important cause of pediatric disease from 2003 through 2012. Differences in the epidemiology and clinical disease result from complex interactions among virus, vector, host, and the environment. Decreasing the morbidity and mortality from these agents depends on vector control, personal protection to reduce mosquito and tick bites, and blood donor screening. Effective surveillance is critical to inform clinicians and public health officials about the epidemiologic features of these diseases and to direct prevention efforts.CONCLUSIONSNeuroinvasive arboviral infections were an important cause of pediatric disease from 2003 through 2012. Differences in the epidemiology and clinical disease result from complex interactions among virus, vector, host, and the environment. Decreasing the morbidity and mortality from these agents depends on vector control, personal protection to reduce mosquito and tick bites, and blood donor screening. Effective surveillance is critical to inform clinicians and public health officials about the epidemiologic features of these diseases and to direct prevention efforts.
Author	Fischer, Marc Gaensbauer, James T Messacar, Kevin Lindsey, Nicole P Staples, J Erin
Author_xml	– sequence: 1 givenname: James T surname: Gaensbauer fullname: Gaensbauer, James T organization: Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado; and – sequence: 2 givenname: Nicole P surname: Lindsey fullname: Lindsey, Nicole P organization: Arboviral Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado – sequence: 3 givenname: Kevin surname: Messacar fullname: Messacar, Kevin organization: Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado; and – sequence: 4 givenname: J Erin surname: Staples fullname: Staples, J Erin organization: Arboviral Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado – sequence: 5 givenname: Marc surname: Fischer fullname: Fischer, Marc email: mfischer@cdc.gov organization: Arboviral Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado mfischer@cdc.gov
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SubjectTerms	Arbovirus Infections - diagnosis Arbovirus Infections - epidemiology Arbovirus Infections - virology Child Encephalitis, California - diagnosis Encephalitis, California - epidemiology Encephalitis, California - virology Humans La Crosse virus - pathogenicity Population Surveillance - methods United States - epidemiology West Nile Fever - diagnosis West Nile Fever - epidemiology West Nile Fever - virology
Title	Neuroinvasive arboviral disease in the United States: 2003 to 2012
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