Structural bioinformatics enhances mechanistic interpretation of genomic variation, demonstrated through the analyses of 935 distinct RAS family mutations

Abstract Motivation Protein-coding genetic alterations are frequently observed in Clinical Genetics, but the high yield of variants of uncertain significance remains a limitation in decision making. RAS-family GTPases are cancer drivers, but only 54 variants, across all family members, fall within w...

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Vydané v:	Bioinformatics Ročník 37; číslo 10; s. 1367 - 1375
Hlavní autori:	Tripathi, Swarnendu, Dsouza, Nikita R, Urrutia, Raul, Zimmermann, Michael T
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England Oxford University Press 16.06.2021
Predmet:	Adult Computational Biology Genomics Humans Mutation, Missense Neoplasms - genetics Original Papers ras Proteins - genetics
ISSN:	1367-4803, 1367-4811, 1460-2059, 1367-4811
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