Iron sucrose accelerates early atherogenesis by increasing superoxide production and upregulating adhesion molecules in CKD

High-dose intravenous iron supplementation is associated with adverse cardiovascular outcomes in patients with CKD, but the underlying mechanism is unknown. Our study investigated the causative role of iron sucrose in leukocyte-endothelium interactions, an index of early atherogenesis, and subsequen...

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Veröffentlicht in:	Journal of the American Society of Nephrology Jg. 25; H. 11; S. 2596
Hauptverfasser:	Kuo, Ko-Lin, Hung, Szu-Chun, Lee, Tzong-Shyuan, Tarng, Der-Cherng
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.11.2014
Schlagworte:	Animals Atherosclerosis - chemically induced Atherosclerosis - metabolism Atherosclerosis - pathology Cell Adhesion - drug effects Cell Adhesion - physiology Endothelial Cells - cytology Ferric Compounds - metabolism Ferric Compounds - pharmacology Glucaric Acid - metabolism Glucaric Acid - pharmacology Humans Injections, Intravenous Intercellular Adhesion Molecule-1 - metabolism Leukocytes - cytology Leukocytes - metabolism Lipid Peroxidation - drug effects Lipid Peroxidation - physiology Male Mice, Inbred C57BL Monocytes - cytology Monocytes - metabolism NF-kappa B - metabolism Renal Insufficiency, Chronic - chemically induced Renal Insufficiency, Chronic - metabolism Renal Insufficiency, Chronic - pathology Superoxides - metabolism U937 Cells Up-Regulation - physiology Vascular Cell Adhesion Molecule-1 - metabolism
ISSN:	1533-3450, 1533-3450
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