GFR Slope as a Surrogate End Point for Kidney Disease Progression in Clinical Trials: A Meta-Analysis of Treatment Effects of Randomized Controlled Trials

Surrogate end points are needed to assess whether treatments are effective in the early stages of CKD. GFR decline leads to kidney failure, but regulators have not approved using differences in the change in GFR from the beginning to the end of a randomized, controlled trial as an end point in CKD b...

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Vydáno v:	Journal of the American Society of Nephrology Ročník 30; číslo 9; s. 1735
Hlavní autoři:	Inker, Lesley A, Heerspink, Hiddo J L, Tighiouart, Hocine, Levey, Andrew S, Coresh, Josef, Gansevoort, Ron T, Simon, Andrew L, Ying, Jian, Beck, Gerald J, Wanner, Christoph, Floege, Jürgen, Li, Philip Kam-Tao, Perkovic, Vlado, Vonesh, Edward F, Greene, Tom
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.09.2019
Témata:	Bayes Theorem Biomarkers Creatinine - blood Disease Progression Glomerular Filtration Rate Humans Kidney Failure, Chronic - etiology Kidney Failure, Chronic - physiopathology Predictive Value of Tests Randomized Controlled Trials as Topic Renal Insufficiency, Chronic - complications Renal Insufficiency, Chronic - physiopathology Renal Insufficiency, Chronic - therapy meta-analysis GFR chronic kidney disease end stage kidney disease randomized controlled trials
ISSN:	1533-3450, 1533-3450
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