Identification of senescent cell surface targetable protein DPP4

Senescent cell accumulation in aging tissues is linked to age-associated diseases and declining function, prompting efforts to eliminate them. Mass spectrometry analysis revealed that DPP4 (dipeptidyl peptidase 4) was selectively expressed on the surface of senescent, but not proliferating, human di...

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Vydané v:	Genes & development Ročník 31; číslo 15; s. 1529
Hlavní autori:	Kim, Kyoung Mi, Noh, Ji Heon, Bodogai, Monica, Martindale, Jennifer L, Yang, Xiaoling, Indig, Fred E, Basu, Sandip K, Ohnuma, Kei, Morimoto, Chikao, Johnson, Peter F, Biragyn, Arya, Abdelmohsen, Kotb, Gorospe, Myriam
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.08.2017
Predmet:	Adult Aged Aged, 80 and over Antibody-Dependent Cell Cytotoxicity Cells, Cultured Cellular Senescence - physiology Cyclin-Dependent Kinase Inhibitor p16 - genetics Dipeptidyl Peptidase 4 - metabolism Diploidy Fibroblasts - metabolism Flow Cytometry Humans Killer Cells, Natural - metabolism Lymphocyte Subsets - enzymology Mass Spectrometry Membrane Proteins - metabolism RNA, Messenger - metabolism RNA, Ribosomal - metabolism human diploid fibroblasts CD26 cell senescence
ISSN:	1549-5477, 1549-5477
On-line prístup:	Zistit podrobnosti o prístupe
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