Identification of senescent cell surface targetable protein DPP4

Senescent cell accumulation in aging tissues is linked to age-associated diseases and declining function, prompting efforts to eliminate them. Mass spectrometry analysis revealed that DPP4 (dipeptidyl peptidase 4) was selectively expressed on the surface of senescent, but not proliferating, human di...

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Veröffentlicht in:	Genes & development Jg. 31; H. 15; S. 1529
Hauptverfasser:	Kim, Kyoung Mi, Noh, Ji Heon, Bodogai, Monica, Martindale, Jennifer L, Yang, Xiaoling, Indig, Fred E, Basu, Sandip K, Ohnuma, Kei, Morimoto, Chikao, Johnson, Peter F, Biragyn, Arya, Abdelmohsen, Kotb, Gorospe, Myriam
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.08.2017
Schlagworte:	Adult Aged Aged, 80 and over Antibody-Dependent Cell Cytotoxicity Cells, Cultured Cellular Senescence - physiology Cyclin-Dependent Kinase Inhibitor p16 - genetics Dipeptidyl Peptidase 4 - metabolism Diploidy Fibroblasts - metabolism Flow Cytometry Humans Killer Cells, Natural - metabolism Lymphocyte Subsets - enzymology Mass Spectrometry Membrane Proteins - metabolism RNA, Messenger - metabolism RNA, Ribosomal - metabolism human diploid fibroblasts CD26 cell senescence
ISSN:	1549-5477, 1549-5477
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