Challenges to DNA replication in hypoxic conditions

The term hypoxia refers to any condition where insufficient oxygen is available and therefore encompasses a range of actual oxygen concentrations. The regions of tumours adjacent to necrotic areas are at almost anoxic levels and are known to be extremely therapy resistant (radiobiological hypoxia)....

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Bibliographic Details
Published in:	The FEBS journal Vol. 285; no. 9; pp. 1563 - 1571
Main Authors:	Ng, Natalie, Purshouse, Karin, Foskolou, Iosifina P., Olcina, Monica M., Hammond, Ester M.
Format:	Journal Article
Language:	English
Published:	England Blackwell Publishing Ltd 01.05.2018
Subjects:	anaerobic conditions Animals Cell Cycle Proteins - physiology Cell Hypoxia - physiology Damage accumulation Damage detection Deoxyribonucleic acid Deoxyribonucleotides - metabolism DNA DNA biosynthesis DNA Damage DNA damage response DNA Repair DNA replication DNA Replication - drug effects DNA-Binding Proteins - physiology Humans Hypoxia neoplasms Neoplasms - genetics Oxygen Oxygen - pharmacology reoxygenation Replication replication restart replication stress ribonucleotide reductase Ribonucleotide Reductases - metabolism Stress, Physiological - genetics therapeutics Tumor Microenvironment Tumors hypoxia ribonucleotide reductase replication stress reoxygenation DNA damage response replication restart
ISSN:	1742-464X, 1742-4658, 1742-4658
Online Access:	Get full text
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