Challenges to DNA replication in hypoxic conditions

The term hypoxia refers to any condition where insufficient oxygen is available and therefore encompasses a range of actual oxygen concentrations. The regions of tumours adjacent to necrotic areas are at almost anoxic levels and are known to be extremely therapy resistant (radiobiological hypoxia)....

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Veröffentlicht in:The FEBS journal Jg. 285; H. 9; S. 1563 - 1571
Hauptverfasser: Ng, Natalie, Purshouse, Karin, Foskolou, Iosifina P., Olcina, Monica M., Hammond, Ester M.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Blackwell Publishing Ltd 01.05.2018
Schlagworte:
anaerobic conditions
Animals
Cell Cycle Proteins - physiology
Cell Hypoxia - physiology
Damage accumulation
Damage detection
Deoxyribonucleic acid
Deoxyribonucleotides - metabolism
DNA
DNA biosynthesis
DNA Damage
DNA damage response
DNA Repair
DNA replication
DNA Replication - drug effects
DNA-Binding Proteins - physiology
Humans
Hypoxia
neoplasms
Neoplasms - genetics
Oxygen
Oxygen - pharmacology
reoxygenation
Replication
replication restart
replication stress
ribonucleotide reductase
Ribonucleotide Reductases - metabolism
Stress, Physiological - genetics
therapeutics
Tumor Microenvironment
Tumors
hypoxia
ribonucleotide reductase
replication stress
reoxygenation
DNA damage response
replication restart
ISSN:1742-464X, 1742-4658, 1742-4658
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Abstract The term hypoxia refers to any condition where insufficient oxygen is available and therefore encompasses a range of actual oxygen concentrations. The regions of tumours adjacent to necrotic areas are at almost anoxic levels and are known to be extremely therapy resistant (radiobiological hypoxia). The biological response to radiobiological hypoxia includes the rapid accumulation of replication stress and subsequent DNA damage response, including both ATR‐ and ATM‐mediated signalling, despite the absence of detectable DNA damage. The causes and consequences of hypoxia‐induced replication stress will be discussed. Ribonucleotide reductase (RNR) is a key enzyme required for the synthesis of nucleotides for subsequent incorporation into DNA. In hypoxic (low oxygen) conditions, the composition of RNR is altered to include a stress specific subunit, RRM2B. RRM2B is adapted to function in hypoxic conditions and therefore continue the synthesis of nucleotides.
AbstractList The term hypoxia refers to any condition where insufficient oxygen is available and therefore encompasses a range of actual oxygen concentrations. The regions of tumours adjacent to necrotic areas are at almost anoxic levels and are known to be extremely therapy resistant (radiobiological hypoxia). The biological response to radiobiological hypoxia includes the rapid accumulation of replication stress and subsequent DNA damage response, including both ATR- and ATM-mediated signalling, despite the absence of detectable DNA damage. The causes and consequences of hypoxia-induced replication stress will be discussed.The term hypoxia refers to any condition where insufficient oxygen is available and therefore encompasses a range of actual oxygen concentrations. The regions of tumours adjacent to necrotic areas are at almost anoxic levels and are known to be extremely therapy resistant (radiobiological hypoxia). The biological response to radiobiological hypoxia includes the rapid accumulation of replication stress and subsequent DNA damage response, including both ATR- and ATM-mediated signalling, despite the absence of detectable DNA damage. The causes and consequences of hypoxia-induced replication stress will be discussed.
The term hypoxia refers to any condition where insufficient oxygen is available and therefore encompasses a range of actual oxygen concentrations. The regions of tumours adjacent to necrotic areas are at almost anoxic levels and are known to be extremely therapy resistant (radiobiological hypoxia). The biological response to radiobiological hypoxia includes the rapid accumulation of replication stress and subsequent DNA damage response, including both ATR‐ and ATM‐mediated signalling, despite the absence of detectable DNA damage. The causes and consequences of hypoxia‐induced replication stress will be discussed.
The term hypoxia refers to any condition where insufficient oxygen is available and therefore encompasses a range of actual oxygen concentrations. The regions of tumours adjacent to necrotic areas are at almost anoxic levels and are known to be extremely therapy resistant (radiobiological hypoxia). The biological response to radiobiological hypoxia includes the rapid accumulation of replication stress and subsequent DNA damage response, including both ATR‐ and ATM‐mediated signalling, despite the absence of detectable DNA damage. The causes and consequences of hypoxia‐induced replication stress will be discussed. Ribonucleotide reductase (RNR) is a key enzyme required for the synthesis of nucleotides for subsequent incorporation into DNA. In hypoxic (low oxygen) conditions, the composition of RNR is altered to include a stress specific subunit, RRM2B. RRM2B is adapted to function in hypoxic conditions and therefore continue the synthesis of nucleotides.
Author Purshouse, Karin
Ng, Natalie
Foskolou, Iosifina P.
Hammond, Ester M.
Olcina, Monica M.
Author_xml – sequence: 1
  givenname: Natalie
  surname: Ng
  fullname: Ng, Natalie
  organization: University of Oxford
– sequence: 2
  givenname: Karin
  surname: Purshouse
  fullname: Purshouse, Karin
  organization: University of Oxford
– sequence: 3
  givenname: Iosifina P.
  surname: Foskolou
  fullname: Foskolou, Iosifina P.
  organization: University of Oxford
– sequence: 4
  givenname: Monica M.
  surname: Olcina
  fullname: Olcina, Monica M.
  organization: Stanford University
– sequence: 5
  givenname: Ester M.
  orcidid: 0000-0002-2335-3146
  surname: Hammond
  fullname: Hammond, Ester M.
  email: ester.hammond@oncology.ox.ac.uk
  organization: University of Oxford
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29288533$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1242/jcs.092262
10.1158/1078-0432.CCR-10-0286
10.1016/j.bbcan.2016.06.004
10.1074/jbc.M106088200
10.1073/pnas.1211289109
10.1101/cshperspect.a026211
10.1038/35087613
10.1038/ncb3415
10.1259/0007-1285-26-312-638
10.1038/nrc2344
10.1093/nar/gkr420
10.1038/sj.emboj.7600369
10.1038/nature03485
10.1007/s10555-007-9055-1
10.1038/sj.onc.1208332
10.1016/j.cell.2012.03.043
10.1016/j.molcel.2017.05.001
10.1038/ng1212
10.1080/23723556.2017.1335272
10.1186/2041-9414-4-5
10.1158/0008-5472.CAN-14-0306
10.1038/onc.2014.155
10.1016/j.molonc.2016.07.008
10.1016/j.biochi.2016.01.008
10.1097/JTO.0b013e3181a949b2
10.1016/j.niox.2008.04.011
10.1101/gad.214080.113
10.1038/nrm3562
10.1016/j.molcel.2013.10.019
10.1158/1541-7786.MCR-14-0246
10.1126/science.1083430
10.1158/0008-5472.CAN-15-0608
10.4161/mco.29903
10.1038/nature08467
10.1128/MCB.01301-08
10.1146/annurev.biochem.75.103004.142443
10.1007/978-3-319-26666-4_2
10.1016/j.dnarep.2004.03.035
10.1158/1078-0432.CCR-06-0613
10.1016/j.radonc.2016.10.023
10.1038/ncb3422
10.1038/srep21698
10.1038/ncb2897
10.1016/j.ctrv.2013.03.002
10.1128/MCB.22.6.1834-1843.2002
10.1016/S0021-9258(18)62745-0
10.1038/nrm2450
10.1038/bjc.2012.265
10.1126/science.aaf4405
10.4161/cc.9.13.12059
10.1016/j.molcel.2017.05.015
10.1016/j.molcel.2017.03.005
10.1016/j.addr.2009.04.018
10.1016/j.dnarep.2010.12.004
10.1158/0008-5472.CAN-09-2715
10.1016/j.ajhg.2009.07.009
10.1001/archneurol.2009.139
10.1128/MCB.26.9.3492-3504.2006
10.1038/ng2040
10.1016/j.nmd.2008.11.014
10.1016/S0092-8674(03)00896-1
10.1074/jbc.M701310200
10.2307/3580087
10.2307/3579024
10.1074/jbc.M312482200
10.1073/pnas.0803313105
10.1016/0092-8674(93)90413-K
10.1146/annurev-med-081313-121208
10.1158/0008-5472.CAN-04-1520
10.1158/0008-5472.CAN-14-3502
10.1016/j.cub.2016.10.030
10.1677/erc.1.01290
10.1038/nrm2852
10.1016/j.cell.2013.10.043
10.1038/nature03482
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Issue 9
Keywords hypoxia
ribonucleotide reductase
replication stress
reoxygenation
DNA damage response
replication restart
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References 2007; 39
2010; 11
2015; 34
2004; 64
2010; 16
2009; 85
2013; 4
2006; 75
2013; 27
2017; 4
1970; 245
2015; 75
2004; 23
2008; 9
2016; 76
2004; 3
2008; 8
2011; 10
2008; 105
2012; 125
2003; 115
2005; 24
2014; 1
2013; 14
1999; 59
2013; 52
1993; 74
2006; 26
2014; 16
2013; 155
2016; 352
1953; 26
2010; 70
2009; 19
2001; 412
2014; 12
2007; 26
2010; 9
2009; 66
2015; 6
2006; 12
2007; 282
2006; 13
2009; 61
2017; 66
2008; 19
2005; 434
2013; 86
2006; 15
2016; 10
2016; 1866
2016; 123
2016; 121
2016; 18
2011; 39
2014; 40
2012; 149
2012; 107
2009; 29
2012; 109
2003; 34
2001; 276
2016; 6
2004; 279
2016; 899
2015; 66
2002; 22
1999; 152
2009; 461
2009; 4
1995; 142
2014; 74
2003; 300
2016; 26
2003; 63
e_1_2_11_70_1
e_1_2_11_32_1
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e_1_2_11_6_1
e_1_2_11_27_1
e_1_2_11_4_1
e_1_2_11_48_1
e_1_2_11_2_1
e_1_2_11_60_1
e_1_2_11_81_1
e_1_2_11_20_1
e_1_2_11_45_1
e_1_2_11_66_1
e_1_2_11_47_1
e_1_2_11_68_1
e_1_2_11_24_1
e_1_2_11_41_1
e_1_2_11_62_1
e_1_2_11_8_1
e_1_2_11_22_1
e_1_2_11_43_1
e_1_2_11_64_1
e_1_2_11_17_1
e_1_2_11_15_1
e_1_2_11_59_1
e_1_2_11_38_1
Olcina MM (e_1_2_11_55_1) 2014; 1
e_1_2_11_19_1
Lee Y (e_1_2_11_78_1) 2003; 63
e_1_2_11_50_1
e_1_2_11_71_1
e_1_2_11_10_1
e_1_2_11_31_1
e_1_2_11_56_1
e_1_2_11_77_1
e_1_2_11_58_1
e_1_2_11_79_1
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e_1_2_11_73_1
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e_1_2_11_33_1
e_1_2_11_54_1
e_1_2_11_75_1
e_1_2_11_7_1
Glazer PM (e_1_2_11_9_1) 2013; 86
e_1_2_11_28_1
e_1_2_11_5_1
e_1_2_11_26_1
Wasylishen AR (e_1_2_11_72_1) 2015; 6
e_1_2_11_3_1
e_1_2_11_49_1
Alarcón R (e_1_2_11_69_1) 1999; 59
Juhasz A (e_1_2_11_76_1) 2006; 15
e_1_2_11_61_1
e_1_2_11_80_1
e_1_2_11_21_1
e_1_2_11_44_1
e_1_2_11_67_1
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References_xml – volume: 86
  start-page: 443
  year: 2013
  end-page: 451
  article-title: Hypoxia and DNA repair
  publication-title: Yale J Biol Med
– volume: 64
  start-page: 6556
  year: 2004
  end-page: 6562
  article-title: Inhibition of ATR leads to increased sensitivity to hypoxia/reoxygenation
  publication-title: Cancer Res
– volume: 52
  start-page: 758
  year: 2013
  end-page: 766
  article-title: Replication stress and chromatin context link ATM activation to a role in DNA replication
  publication-title: Mol Cell
– volume: 4
  start-page: e1335272
  year: 2017
  article-title: RRM2B: an oxygen‐requiring protein with a role in hypoxia
  publication-title: Mol Cell Oncol
– volume: 59
  start-page: 6046
  year: 1999
  end-page: 6051
  article-title: Hypoxia induces p53 accumulation through MDM2 down‐regulation and inhibition of E6‐mediated degradation
  publication-title: Cancer Res
– volume: 11
  start-page: 208
  year: 2010
  end-page: 219
  article-title: Maintaining genome stability at the replication fork
  publication-title: Nat Rev Mol Cell Biol
– volume: 121
  start-page: 232
  year: 2016
  end-page: 238
  article-title: Preclinical testing of an Atr inhibitor demonstrates improved response to standard therapies for esophageal cancer
  publication-title: Radiother Oncol
– volume: 66
  start-page: 801
  year: 2017
  end-page: 817
  article-title: ATM, ATR, and DNA‐PK: the trinity at the heart of the DNA damage response
  publication-title: Mol Cell
– volume: 899
  start-page: 11
  year: 2016
  end-page: 25
  article-title: Measuring DNA replication in hypoxic conditions
  publication-title: Adv Exp Med Biol
– volume: 39
  start-page: 776
  year: 2007
  end-page: 780
  article-title: Mutation of RRM2B, encoding p53‐controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion
  publication-title: Nat Genet
– volume: 245
  start-page: 5228
  year: 1970
  end-page: 5233
  article-title: Ribonucleotide reductase and cell proliferation. I. Variations of ribonucleotide reductase activity with tumor growth rate in a series of rat hepatomas
  publication-title: J Biol Chem
– volume: 155
  start-page: 1088
  year: 2013
  end-page: 1103
  article-title: ATR prohibits replication catastrophe by preventing global exhaustion of RPA
  publication-title: Cell
– volume: 27
  start-page: 1610
  year: 2013
  end-page: 1623
  article-title: ATR phosphorylates SMARCAL1 to prevent replication fork collapse
  publication-title: Genes Dev
– volume: 1
  start-page: e29903
  year: 2014
  article-title: ATM activation in hypoxia – causes and consequences
  publication-title: Mol Cell Oncol
– volume: 9
  start-page: 616
  year: 2008
  end-page: 627
  article-title: ATR: an essential regulator of genome integrity
  publication-title: Nat Rev Mol Cell Biol
– volume: 152
  start-page: 144
  year: 1999
  end-page: 153
  article-title: Effect of oxygen on radiation‐induced DNA damage in isolated nuclei
  publication-title: Radiat Res
– volume: 412
  start-page: 557
  year: 2001
  end-page: 561
  article-title: The DNA replication checkpoint response stabilizes stalled replication forks
  publication-title: Nature
– volume: 13
  start-page: S61
  issue: Suppl 1
  year: 2006
  end-page: S75
  article-title: Role of hypoxia‐inducible factor‐1alpha as a cancer therapy target
  publication-title: Endocr Relat Cancer
– volume: 9
  start-page: 2502
  year: 2010
  end-page: 2507
  article-title: Exposure to acute hypoxia induces a transient DNA damage response which includes Chk1 and TLK1
  publication-title: Cell Cycle
– volume: 85
  start-page: 290
  year: 2009
  end-page: 295
  article-title: A heterozygous truncating mutation in RRM2B causes autosomal‐dominant progressive external ophthalmoplegia with multiple mtDNA deletions
  publication-title: Am J Hum Genet
– volume: 66
  start-page: 735
  year: 2017
  end-page: 749
  article-title: Replication catastrophe: when a checkpoint fails because of exhaustion
  publication-title: Mol Cell
– volume: 4
  start-page: 5
  year: 2013
  article-title: Tumor hypoxia as a driving force in genetic instability
  publication-title: Genome Integr
– volume: 1
  start-page: 8
  year: 2014
  article-title: ATM activation in hypoxia – causes and consequences
  publication-title: Mol Cell Oncol
– volume: 105
  start-page: 18519
  year: 2008
  end-page: 18524
  article-title: ATM‐mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage
  publication-title: Proc Natl Acad Sci USA
– volume: 24
  start-page: 949
  year: 2005
  end-page: 961
  article-title: The life and death of DNA‐PK
  publication-title: Oncogene
– volume: 66
  start-page: 129
  year: 2015
  end-page: 143
  article-title: The DNA damage response: implications for tumor responses to radiation and chemotherapy
  publication-title: Annu Rev Med
– volume: 107
  start-page: 291
  year: 2012
  end-page: 299
  article-title: Targeting radiation‐resistant hypoxic tumour cells through ATR inhibition
  publication-title: Br J Cancer
– volume: 10
  start-page: 1375
  year: 2016
  end-page: 1386
  article-title: A ribonucleotide reductase inhibitor with deoxyribonucleoside‐reversible cytotoxicity
  publication-title: Mol Oncol
– volume: 76
  start-page: 1078
  year: 2016
  end-page: 1088
  article-title: DNA‐PKcs and PARP1 bind to unresected stalled DNA replication forks where they recruit XRCC1 to mediate repair
  publication-title: Cancer Res
– volume: 18
  start-page: 1196
  year: 2016
  end-page: 1207
  article-title: Activation of the ATR kinase by the RPA‐binding protein ETAA1
  publication-title: Nat Cell Biol
– volume: 461
  start-page: 1071
  year: 2009
  end-page: 1078
  article-title: The DNA‐damage response in human biology and disease
  publication-title: Nature
– volume: 29
  start-page: 526
  year: 2009
  end-page: 537
  article-title: ATM activation and signaling under hypoxic conditions
  publication-title: Mol Cell Biol
– volume: 4
  start-page: 1163
  year: 2009
  end-page: 1169
  article-title: A phase I/II study of GTI‐2040 plus docetaxel as second‐line treatment in advanced non‐small cell lung cancer: a study of the PMH phase II consortium
  publication-title: J Thorac Oncol
– volume: 19
  start-page: 84
  year: 2008
  end-page: 94
  article-title: Upregulation of the p53R2 ribonucleotide reductase subunit by nitric oxide
  publication-title: Nitric Oxide
– volume: 434
  start-page: 864
  year: 2005
  end-page: 870
  article-title: DNA damage response as a candidate anti‐cancer barrier in early human tumorigenesis
  publication-title: Nature
– volume: 300
  start-page: 1542
  year: 2003
  end-page: 1548
  article-title: Sensing DNA damage through ATRIP recognition of RPA‐ssDNA complexes
  publication-title: Science
– volume: 12
  start-page: 5007
  year: 2006
  end-page: 5009
  article-title: Hypoxia‐inducible factor‐1 and p53: friends, acquaintances, or strangers?
  publication-title: Clin Cancer Res
– volume: 14
  start-page: 269
  year: 2013
  end-page: 282
  article-title: Regulation of PCNA‐protein interactions for genome stability
  publication-title: Nat Rev Mol Cell Biol
– volume: 16
  start-page: 2
  year: 2014
  end-page: 9
  article-title: Causes and consequences of replication stress
  publication-title: Nat Cell Biol
– volume: 19
  start-page: 147
  year: 2009
  end-page: 150
  article-title: A novel homozygous RRM2B missense mutation in association with severe mtDNA depletion
  publication-title: Neuromuscul Disord
– volume: 6
  start-page: 21698
  year: 2016
  article-title: Mechanisms and consequences of ATMIN repression in hypoxic conditions: roles for p53 and HIF‐1
  publication-title: Sci Rep
– volume: 123
  start-page: 81
  year: 2016
  end-page: 84
  article-title: Novel regulators and molecular mechanisms of p53R2 and its disease relevance
  publication-title: Biochimie
– volume: 26
  start-page: 3257
  year: 2016
  end-page: 3268
  article-title: RPA‐binding protein ETAA1 is an ATR activator involved in DNA replication stress response
  publication-title: Curr Biol
– volume: 26
  start-page: 225
  year: 2007
  end-page: 239
  article-title: Hypoxia in cancer: significance and impact on clinical outcome
  publication-title: Cancer Metastasis Rev
– volume: 125
  start-page: 189
  issue: Pt 1
  year: 2012
  end-page: 199
  article-title: Chronic hypoxia compromises repair of DNA double‐strand breaks to drive genetic instability
  publication-title: J Cell Sci
– volume: 142
  start-page: 163
  year: 1995
  end-page: 168
  article-title: Radiation‐induced DNA damage in tumors and normal tissues. III. Oxygen dependence of the formation of strand breaks and DNA‐protein crosslinks
  publication-title: Radiat Res
– volume: 39
  start-page: 7049
  year: 2011
  end-page: 7057
  article-title: UV stalled replication forks restart by re‐priming in human fibroblasts
  publication-title: Nucleic Acids Res
– volume: 18
  start-page: 1185
  year: 2016
  end-page: 1195
  article-title: ETAA1 acts at stalled replication forks to maintain genome integrity
  publication-title: Nat Cell Biol
– volume: 34
  start-page: 2011
  year: 2015
  end-page: 2021
  article-title: Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies
  publication-title: Oncogene
– volume: 74
  start-page: 5165
  year: 2014
  end-page: 5172
  article-title: RPA inhibition increases replication stress and suppresses tumor growth
  publication-title: Cancer Res
– volume: 8
  start-page: 180
  year: 2008
  end-page: 192
  article-title: Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability
  publication-title: Nat Rev Cancer
– volume: 282
  start-page: 16820
  year: 2007
  end-page: 16828
  article-title: p53R2‐dependent ribonucleotide reduction provides deoxyribonucleotides in quiescent human fibroblasts in the absence of induced DNA damage
  publication-title: J Biol Chem
– volume: 40
  start-page: 109
  year: 2014
  end-page: 117
  article-title: Targeting ATR in DNA damage response and cancer therapeutics
  publication-title: Cancer Treat Rev
– volume: 26
  start-page: 3492
  year: 2006
  end-page: 3504
  article-title: Genome‐wide analysis of p53 under hypoxic conditions
  publication-title: Mol Cell Biol
– volume: 16
  start-page: 5624
  year: 2010
  end-page: 5629
  article-title: Targeting hypoxic cells through the DNA damage response
  publication-title: Clin Cancer Res
– volume: 75
  start-page: 2159
  year: 2015
  end-page: 2165
  article-title: Mechanistic rationale to target PTEN‐deficient tumor cells with inhibitors of the DNA damage response kinase ATM
  publication-title: Cancer Res
– volume: 1866
  start-page: 76
  year: 2016
  end-page: 86
  article-title: Cycling hypoxia: a key feature of the tumor microenvironment
  publication-title: Biochim Biophys Acta
– volume: 34
  start-page: 440
  year: 2003
  end-page: 445
  article-title: Impaired function of p53R2 in Rrm2b‐null mice causes severe renal failure through attenuation of dNTP pools
  publication-title: Nat Genet
– volume: 115
  start-page: 537
  year: 2003
  end-page: 549
  article-title: A Rad53 kinase‐dependent surveillance mechanism that regulates histone protein levels in
  publication-title: Cell
– volume: 23
  start-page: 3667
  year: 2004
  end-page: 3676
  article-title: A requirement for MCM7 and Cdc45 in chromosome unwinding during eukaryotic DNA replication
  publication-title: EMBO J
– volume: 109
  start-page: 13302
  year: 2012
  end-page: 13307
  article-title: Mammalian ribonucleotide reductase subunit p53R2 is required for mitochondrial DNA replication and DNA repair in quiescent cells
  publication-title: Proc Natl Acad Sci USA
– volume: 15
  start-page: 1299
  year: 2006
  end-page: 1304
  article-title: Analysis of ribonucleotide reductase M2 mRNA levels in patient samples after GTI‐2040 antisense drug treatment
  publication-title: Oncol Rep
– volume: 6
  start-page: a026211
  year: 2015
  article-title: Attenuating the p53 pathway in human cancers: many means to the same end
  publication-title: Cold Spring Harb Perspect Med
– volume: 75
  start-page: 681
  year: 2006
  end-page: 706
  article-title: Ribonucleotide reductases
  publication-title: Annu Rev Biochem
– volume: 22
  start-page: 1834
  year: 2002
  end-page: 1843
  article-title: Hypoxia links ATR and p53 through replication arrest
  publication-title: Mol Cell Biol
– volume: 66
  start-page: 1028
  year: 2009
  end-page: 1032
  article-title: Mitochondrial neurogastrointestinal encephalopathy due to mutations in RRM2B
  publication-title: Arch Neurol
– volume: 352
  start-page: 175
  year: 2016
  end-page: 180
  article-title: Hypoxic control of metastasis
  publication-title: Science
– volume: 3
  start-page: 1117
  year: 2004
  end-page: 1122
  article-title: The role of ATM and ATR in the cellular response to hypoxia and re‐oxygenation
  publication-title: DNA Repair (Amst)
– volume: 12
  start-page: 1407
  year: 2014
  end-page: 1415
  article-title: Hypoxia provokes base excision repair changes and a repair‐deficient, mutator phenotype in colorectal cancer cells
  publication-title: Mol Cancer Res
– volume: 10
  start-page: 344
  year: 2011
  end-page: 348
  article-title: DNA end resection–unraveling the tail
  publication-title: DNA Repair (Amst)
– volume: 63
  start-page: 2802
  year: 2003
  end-page: 2811
  article-title: GTI‐2040, an antisense agent targeting the small subunit component (R2) of human ribonucleotide reductase, shows potent antitumor activity against a variety of tumors
  publication-title: Cancer Res
– volume: 434
  start-page: 907
  year: 2005
  end-page: 913
  article-title: Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
  publication-title: Nature
– volume: 26
  start-page: 638
  year: 1953
  end-page: 648
  article-title: The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy
  publication-title: Br J Radiol
– volume: 61
  start-page: 850
  year: 2009
  end-page: 862
  article-title: siRNA delivery systems for cancer treatment
  publication-title: Adv Drug Deliv Rev
– volume: 276
  start-page: 40647
  year: 2001
  end-page: 40651
  article-title: Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells
  publication-title: J Biol Chem
– volume: 74
  start-page: 223
  year: 1993
  end-page: 226
  article-title: Exercising self‐restraint: discouraging illicit acts of S and M in eukaryotes
  publication-title: Cell
– volume: 149
  start-page: 1023
  year: 2012
  end-page: 1034
  article-title: Cyclin F‐mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair
  publication-title: Cell
– volume: 70
  start-page: 925
  year: 2010
  end-page: 935
  article-title: Effects of acute versus chronic hypoxia on DNA damage responses and genomic instability
  publication-title: Cancer Res
– volume: 66
  start-page: 206
  year: 2017
  end-page: 220
  article-title: Ribonucleotide reductase requires subunit switching in hypoxia to maintain DNA replication
  publication-title: Mol Cell
– volume: 279
  start-page: 10796
  year: 2004
  end-page: 10807
  article-title: S phase‐specific transcription of the mouse ribonucleotide reductase R2 gene requires both a proximal repressive E2F‐binding site and an upstream promoter activating region
  publication-title: J Biol Chem
– ident: e_1_2_11_7_1
  doi: 10.1242/jcs.092262
– ident: e_1_2_11_54_1
  doi: 10.1158/1078-0432.CCR-10-0286
– ident: e_1_2_11_51_1
  doi: 10.1016/j.bbcan.2016.06.004
– ident: e_1_2_11_60_1
  doi: 10.1074/jbc.M106088200
– ident: e_1_2_11_61_1
  doi: 10.1073/pnas.1211289109
– volume: 6
  start-page: a026211
  year: 2015
  ident: e_1_2_11_72_1
  article-title: Attenuating the p53 pathway in human cancers: many means to the same end
  publication-title: Cold Spring Harb Perspect Med
  doi: 10.1101/cshperspect.a026211
– ident: e_1_2_11_28_1
  doi: 10.1038/35087613
– ident: e_1_2_11_27_1
  doi: 10.1038/ncb3415
– ident: e_1_2_11_6_1
  doi: 10.1259/0007-1285-26-312-638
– ident: e_1_2_11_5_1
  doi: 10.1038/nrc2344
– ident: e_1_2_11_32_1
  doi: 10.1093/nar/gkr420
– ident: e_1_2_11_21_1
  doi: 10.1038/sj.emboj.7600369
– ident: e_1_2_11_81_1
  doi: 10.1038/nature03485
– ident: e_1_2_11_4_1
  doi: 10.1007/s10555-007-9055-1
– volume: 63
  start-page: 2802
  year: 2003
  ident: e_1_2_11_78_1
  article-title: GTI‐2040, an antisense agent targeting the small subunit component (R2) of human ribonucleotide reductase, shows potent antitumor activity against a variety of tumors
  publication-title: Cancer Res
– ident: e_1_2_11_39_1
  doi: 10.1038/sj.onc.1208332
– ident: e_1_2_11_58_1
  doi: 10.1016/j.cell.2012.03.043
– volume: 59
  start-page: 6046
  year: 1999
  ident: e_1_2_11_69_1
  article-title: Hypoxia induces p53 accumulation through MDM2 down‐regulation and inhibition of E6‐mediated degradation
  publication-title: Cancer Res
– ident: e_1_2_11_34_1
  doi: 10.1016/j.molcel.2017.05.001
– ident: e_1_2_11_66_1
  doi: 10.1038/ng1212
– ident: e_1_2_11_67_1
  doi: 10.1080/23723556.2017.1335272
– ident: e_1_2_11_8_1
  doi: 10.1186/2041-9414-4-5
– ident: e_1_2_11_22_1
  doi: 10.1158/0008-5472.CAN-14-0306
– ident: e_1_2_11_73_1
  doi: 10.1038/onc.2014.155
– ident: e_1_2_11_75_1
  doi: 10.1016/j.molonc.2016.07.008
– ident: e_1_2_11_71_1
  doi: 10.1016/j.biochi.2016.01.008
– ident: e_1_2_11_77_1
  doi: 10.1097/JTO.0b013e3181a949b2
– ident: e_1_2_11_70_1
  doi: 10.1016/j.niox.2008.04.011
– ident: e_1_2_11_29_1
  doi: 10.1101/gad.214080.113
– ident: e_1_2_11_33_1
  doi: 10.1038/nrm3562
– ident: e_1_2_11_14_1
  doi: 10.1016/j.molcel.2013.10.019
– ident: e_1_2_11_53_1
  doi: 10.1158/1541-7786.MCR-14-0246
– ident: e_1_2_11_24_1
  doi: 10.1126/science.1083430
– ident: e_1_2_11_40_1
  doi: 10.1158/0008-5472.CAN-15-0608
– ident: e_1_2_11_41_1
  doi: 10.4161/mco.29903
– ident: e_1_2_11_38_1
  doi: 10.1038/nature08467
– ident: e_1_2_11_49_1
  doi: 10.1128/MCB.01301-08
– volume: 15
  start-page: 1299
  year: 2006
  ident: e_1_2_11_76_1
  article-title: Analysis of ribonucleotide reductase M2 mRNA levels in patient samples after GTI‐2040 antisense drug treatment
  publication-title: Oncol Rep
– ident: e_1_2_11_56_1
  doi: 10.1146/annurev.biochem.75.103004.142443
– ident: e_1_2_11_43_1
  doi: 10.1007/978-3-319-26666-4_2
– ident: e_1_2_11_13_1
  doi: 10.1016/j.dnarep.2004.03.035
– ident: e_1_2_11_45_1
  doi: 10.1158/1078-0432.CCR-06-0613
– ident: e_1_2_11_47_1
  doi: 10.1016/j.radonc.2016.10.023
– ident: e_1_2_11_26_1
  doi: 10.1038/ncb3422
– ident: e_1_2_11_10_1
  doi: 10.1038/srep21698
– ident: e_1_2_11_35_1
  doi: 10.1038/ncb2897
– ident: e_1_2_11_48_1
  doi: 10.1016/j.ctrv.2013.03.002
– ident: e_1_2_11_11_1
  doi: 10.1128/MCB.22.6.1834-1843.2002
– ident: e_1_2_11_74_1
  doi: 10.1016/S0021-9258(18)62745-0
– ident: e_1_2_11_23_1
  doi: 10.1038/nrm2450
– ident: e_1_2_11_46_1
  doi: 10.1038/bjc.2012.265
– ident: e_1_2_11_2_1
  doi: 10.1126/science.aaf4405
– ident: e_1_2_11_15_1
  doi: 10.4161/cc.9.13.12059
– ident: e_1_2_11_42_1
  doi: 10.1016/j.molcel.2017.05.015
– ident: e_1_2_11_50_1
  doi: 10.1016/j.molcel.2017.03.005
– ident: e_1_2_11_79_1
  doi: 10.1016/j.addr.2009.04.018
– ident: e_1_2_11_20_1
  doi: 10.1016/j.dnarep.2010.12.004
– ident: e_1_2_11_44_1
  doi: 10.1158/0008-5472.CAN-09-2715
– ident: e_1_2_11_65_1
  doi: 10.1016/j.ajhg.2009.07.009
– ident: e_1_2_11_64_1
  doi: 10.1001/archneurol.2009.139
– volume: 1
  start-page: 8
  year: 2014
  ident: e_1_2_11_55_1
  article-title: ATM activation in hypoxia – causes and consequences
  publication-title: Mol Cell Oncol
– ident: e_1_2_11_52_1
  doi: 10.1128/MCB.26.9.3492-3504.2006
– ident: e_1_2_11_59_1
  doi: 10.1038/ng2040
– ident: e_1_2_11_63_1
  doi: 10.1016/j.nmd.2008.11.014
– ident: e_1_2_11_30_1
  doi: 10.1016/S0092-8674(03)00896-1
– ident: e_1_2_11_62_1
  doi: 10.1074/jbc.M701310200
– ident: e_1_2_11_16_1
  doi: 10.2307/3580087
– ident: e_1_2_11_17_1
  doi: 10.2307/3579024
– ident: e_1_2_11_57_1
  doi: 10.1074/jbc.M312482200
– ident: e_1_2_11_68_1
  doi: 10.1073/pnas.0803313105
– ident: e_1_2_11_18_1
  doi: 10.1016/0092-8674(93)90413-K
– volume: 86
  start-page: 443
  year: 2013
  ident: e_1_2_11_9_1
  article-title: Hypoxia and DNA repair
  publication-title: Yale J Biol Med
– ident: e_1_2_11_37_1
  doi: 10.1146/annurev-med-081313-121208
– ident: e_1_2_11_12_1
  doi: 10.1158/0008-5472.CAN-04-1520
– ident: e_1_2_11_36_1
  doi: 10.1158/0008-5472.CAN-14-3502
– ident: e_1_2_11_25_1
  doi: 10.1016/j.cub.2016.10.030
– ident: e_1_2_11_3_1
  doi: 10.1677/erc.1.01290
– ident: e_1_2_11_19_1
  doi: 10.1038/nrm2852
– ident: e_1_2_11_31_1
  doi: 10.1016/j.cell.2013.10.043
– ident: e_1_2_11_80_1
  doi: 10.1038/nature03482
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Snippet The term hypoxia refers to any condition where insufficient oxygen is available and therefore encompasses a range of actual oxygen concentrations. The regions...
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SubjectTerms anaerobic conditions
Animals
Cell Cycle Proteins - physiology
Cell Hypoxia - physiology
Damage accumulation
Damage detection
Deoxyribonucleic acid
Deoxyribonucleotides - metabolism
DNA
DNA biosynthesis
DNA Damage
DNA damage response
DNA Repair
DNA replication
DNA Replication - drug effects
DNA-Binding Proteins - physiology
Humans
Hypoxia
neoplasms
Neoplasms - genetics
Oxygen
Oxygen - pharmacology
reoxygenation
Replication
replication restart
replication stress
ribonucleotide reductase
Ribonucleotide Reductases - metabolism
Stress, Physiological - genetics
therapeutics
Tumor Microenvironment
Tumors
Title Challenges to DNA replication in hypoxic conditions
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Ffebs.14377
https://www.ncbi.nlm.nih.gov/pubmed/29288533
https://www.proquest.com/docview/2035581353
https://www.proquest.com/docview/1982838853
https://www.proquest.com/docview/2084076169
Volume 285
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