Clinical phenotype and outcome of hepatitis E virus-associated neuralgic amyotrophy

To determine the clinical phenotype and outcome in hepatitis E virus-associated neuralgic amyotrophy (HEV-NA). Cases of NA were identified in 11 centers from 7 European countries, with retrospective analysis of demographics, clinical/laboratory findings, and treatment and outcome. Cases of HEV-NA we...

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Vydáno v:	Neurology Ročník 89; číslo 9; s. 909
Hlavní autoři:	van Eijk, Jeroen J J, Dalton, Harry R, Ripellino, Paolo, Madden, Richard G, Jones, Catherine, Fritz, Miriam, Gobbi, Claudio, Melli, Giorgia, Pasi, Emanuela, Herrod, Jenny, Lissmann, Rebecca F, Ashraf, Hamad H, Abdelrahim, Mohamed, Masri, Omar A B A L, Fraga, Montserrat, Benninger, David, Kuntzer, Thierry, Aubert, Vincent, Sahli, Roland, Moradpour, Darius, Blasco-Perrin, Hélène, Attarian, Shahram, Gérolami, Rene, Colson, Philippe, Giordani, Maria T, Hartl, Johannes, Pischke, Sven, Lin, Nan X, Mclean, Brendan N, Bendall, Richard P, Panning, Marcus, Peron, Jean-Marie, Kamar, Nassim, Izopet, Jacques, Jacobs, Bart C, van Alfen, Nens, van Engelen, Baziel G M
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 29.08.2017
Témata:	Adult Aged Aged, 80 and over Brachial Plexus - diagnostic imaging Brachial Plexus - physiopathology Brachial Plexus Neuritis - diagnostic imaging Brachial Plexus Neuritis - drug therapy Brachial Plexus Neuritis - pathology Brachial Plexus Neuritis - physiopathology Europe Female Hepatitis Antibodies - blood Hepatitis E - drug therapy Hepatitis E - pathology Hepatitis E - physiopathology Hepatitis E - virology Hepatitis E virus Humans Immunoglobulin G - blood Immunoglobulin M - blood Liver Function Tests Male Middle Aged Phenotype Retrospective Studies RNA, Viral - blood RNA, Viral - cerebrospinal fluid Treatment Outcome Young Adult
ISSN:	1526-632X, 1526-632X
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Shrnutí:	To determine the clinical phenotype and outcome in hepatitis E virus-associated neuralgic amyotrophy (HEV-NA). Cases of NA were identified in 11 centers from 7 European countries, with retrospective analysis of demographics, clinical/laboratory findings, and treatment and outcome. Cases of HEV-NA were compared with NA cases without evidence of HEV infection. Fifty-seven cases of HEV-NA and 61 NA cases without HEV were studied. Fifty-six of 57 HEV-NA cases were anti-HEV IgM positive; 53/57 were IgG positive. In 38 cases, HEV RNA was recovered from the serum and in 1 from the CSF (all genotype 3). Fifty-one of 57 HEV-NA cases were anicteric; median alanine aminotransferase 259 IU/L (range 12-2,961 IU/L); in 6 cases, liver function tests were normal. HEV-NA cases were more likely to have bilateral involvement (80.0% vs 8.6%, < 0.001), damage outside the brachial plexus (58.5% vs 10.5%, < 0.01), including phrenic nerve and lumbosacral plexus injury (25.0% vs 3.5%, = 0.01, and 26.4% vs 7.0%, = 0.001), reduced reflexes ( = 0.03), sensory symptoms ( = 0.04) with more extensive damage to the brachial plexus. There was no difference in outcome between the 2 groups at 12 months. Patients with HEV-NA are usually anicteric and have a distinct clinical phenotype, with predominately bilateral asymmetrical involvement of, and more extensive damage to, the brachial plexus. Involvement outside the brachial plexus is more common in HEV-NA. The relationship between HEV and NA is likely to be causal, but is easily overlooked. Patients presenting with NA should be tested for HEV, irrespective of liver function test results. Prospective treatment/outcome studies of HEV-NA are warranted.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1526-632X 1526-632X
DOI:	10.1212/WNL.0000000000004297