Low-sodium dietary approaches to stop hypertension diet reduces blood pressure, arterial stiffness, and oxidative stress in hypertensive heart failure with preserved ejection fraction

Recent studies suggest that oxidative stress and vascular dysfunction contribute to heart failure with preserved ejection fraction (HFPEF). In salt-sensitive HFPEF animal models, diets low in sodium and high in potassium, calcium, magnesium, and antioxidants attenuate oxidative stress and cardiovasc...

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Vydané v:Hypertension (Dallas, Tex. 1979) Ročník 60; číslo 5; s. 1200
Hlavní autori: Hummel, Scott L, Seymour, E Mitchell, Brook, Robert D, Kolias, Theodore J, Sheth, Samar S, Rosenblum, Hannah R, Wells, Joanna M, Weder, Alan B
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 01.11.2012
Predmet:
Aged
Aged, 80 and over
Blood Pressure - physiology
Diet, Sodium-Restricted
F2-Isoprostanes - urine
Female
Heart Failure - complications
Heart Failure - diet therapy
Heart Failure - physiopathology
Humans
Hypertension - complications
Hypertension - diet therapy
Hypertension - physiopathology
Male
Middle Aged
Oxidative Stress - physiology
Sodium - urine
Time Factors
Treatment Outcome
Vascular Stiffness - physiology
ISSN:1524-4563, 1524-4563
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Shrnutí:Recent studies suggest that oxidative stress and vascular dysfunction contribute to heart failure with preserved ejection fraction (HFPEF). In salt-sensitive HFPEF animal models, diets low in sodium and high in potassium, calcium, magnesium, and antioxidants attenuate oxidative stress and cardiovascular damage. We hypothesized that the sodium-restricted Dietary Approaches to Stop Hypertension diet (DASH/SRD) would have similar effects in human hypertensive HFPEF. Thirteen patients with treated hypertension and compensated HFPEF consumed the DASH/SRD for 21 days (all food/most beverages provided). The DASH/SRD reduced clinic systolic (155-138 mm Hg; P=0.02) and diastolic blood pressure (79-72 mm Hg; P=0.04), 24-hour ambulatory systolic (130-123 mm Hg; P=0.02) and diastolic blood pressure (67-62 mm Hg; P=0.02), and carotid-femoral pulse wave velocity (12.4-11.0 m/s; P=0.03). Urinary F2-isoprostanes decreased by 31% (209-144 pmol/mmol Cr; P=0.02) despite increased urinary aldosterone excretion. The reduction in urinary F2-isoprostanes closely correlated with the reduction in urinary sodium excretion on the DASH/SRD. In this cohort of HFPEF patients with treated hypertension, the DASH/SRD reduced systemic blood pressure, arterial stiffness, and oxidative stress. These findings are characteristic of salt-sensitive hypertension, a phenotype present in many HFPEF animal models and suggest shared pathophysiological mechanisms linking these 2 conditions. Further dietary modification studies could provide insights into the development and progression of hypertensive HFPEF.
Bibliografia:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:1524-4563
1524-4563
DOI:10.1161/HYPERTENSIONAHA.112.202705