Human dendritic cell line models for DC differentiation and clinical DC vaccination studies

Dendritic cells (DC) are increasingly applied in the immunotherapy of cancer. As the development of a standardized DC vaccine product is often hampered by the limited availability of DC precursors and inter‐ and intra‐donor variability, and the preparation of individual vaccines is labor‐intensive,...

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Vydáno v:Journal of leukocyte biology Ročník 84; číslo 6; s. 1364 - 1373
Hlavní autoři: Santegoets, Saskia J. A. M., Eertwegh, Alfons J. M., Loosdrecht, Arjan A., Scheper, Rik J., Gruijl, Tanja D.
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Society for Leukocyte Biology 01.12.2008
Témata:
biology
Cancer Vaccines - therapeutic use
Cell Differentiation - physiology
Cell Line
Dendritic Cells - physiology
Humans
immunotherapy
interstitial
Langerhans cell
Leukemia - immunology
Leukemia - therapy
Models, Biological
MUTZ‐3
ISSN:0741-5400, 1938-3673
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Abstract Dendritic cells (DC) are increasingly applied in the immunotherapy of cancer. As the development of a standardized DC vaccine product is often hampered by the limited availability of DC precursors and inter‐ and intra‐donor variability, and the preparation of individual vaccines is labor‐intensive, it would be preferable to use DC from a readily available and unlimited source, such as cell lines can provide. It has been described that leukemia‐derived cell lines are able to differentiate into functional DC, creating possibilities for the development of highly reproducible DC vaccines and providing in vitro model systems for in‐depth studies about DC physiology. This review discusses the different human DC cell line differentiation models described so far. Based on the available data, characteristics that determine the ability of leukemia cells to differentiate along the different precursor stages into functional DC will be formulated. In addition, evidence will be provided that the human CD34+ acute myeloid leukemia cell line MUTZ‐3 provides DC that exhibit the functional properties that are crucial for the in vivo generation of CTL‐mediated immunity and thus, currently, represents the most valuable, sustainable model system for myeloid DC differentiation and clinical DC vaccination studies.
AbstractList Dendritic cells (DC) are increasingly applied in the immunotherapy of cancer. As the development of a standardized DC vaccine product is often hampered by the limited availability of DC precursors and inter- and intra-donor variability, and the preparation of individual vaccines is labor-intensive, it would be preferable to use DC from a readily available and unlimited source, such as cell lines can provide. It has been described that leukemia-derived cell lines are able to differentiate into functional DC, creating possibilities for the development of highly reproducible DC vaccines and providing in vitro model systems for in-depth studies about DC physiology. This review discusses the different human DC cell line differentiation models described so far. Based on the available data, characteristics that determine the ability of leukemia cells to differentiate along the different precursor stages into functional DC will be formulated. In addition, evidence will be provided that the human CD34+ acute myeloid leukemia cell line MUTZ-3 provides DC that exhibit the functional properties that are crucial for the in vivo generation of CTL-mediated immunity and thus, currently, represents the most valuable, sustainable model system for myeloid DC differentiation and clinical DC vaccination studies.
Dendritic cells (DC) are increasingly applied in the immunotherapy of cancer. As the development of a standardized DC vaccine product is often hampered by the limited availability of DC precursors and inter- and intra-donor variability, and the preparation of individual vaccines is labor-intensive, it would be preferable to use DC from a readily available and unlimited source, such as cell lines can provide. It has been described that leukemia-derived cell lines are able to differentiate into functional DC, creating possibilities for the development of highly reproducible DC vaccines and providing in vitro model systems for in-depth studies about DC physiology. This review discusses the different human DC cell line differentiation models described so far. Based on the available data, characteristics that determine the ability of leukemia cells to differentiate along the different precursor stages into functional DC will be formulated. In addition, evidence will be provided that the human CD34+ acute myeloid leukemia cell line MUTZ-3 provides DC that exhibit the functional properties that are crucial for the in vivo generation of CTL-mediated immunity and thus, currently, represents the most valuable, sustainable model system for myeloid DC differentiation and clinical DC vaccination studies.Dendritic cells (DC) are increasingly applied in the immunotherapy of cancer. As the development of a standardized DC vaccine product is often hampered by the limited availability of DC precursors and inter- and intra-donor variability, and the preparation of individual vaccines is labor-intensive, it would be preferable to use DC from a readily available and unlimited source, such as cell lines can provide. It has been described that leukemia-derived cell lines are able to differentiate into functional DC, creating possibilities for the development of highly reproducible DC vaccines and providing in vitro model systems for in-depth studies about DC physiology. This review discusses the different human DC cell line differentiation models described so far. Based on the available data, characteristics that determine the ability of leukemia cells to differentiate along the different precursor stages into functional DC will be formulated. In addition, evidence will be provided that the human CD34+ acute myeloid leukemia cell line MUTZ-3 provides DC that exhibit the functional properties that are crucial for the in vivo generation of CTL-mediated immunity and thus, currently, represents the most valuable, sustainable model system for myeloid DC differentiation and clinical DC vaccination studies.
Author Rik J. Scheper
Alfons J. M. van den Eertwegh
Saskia J. A. M. Santegoets
Tanja D. de Gruijl
Arjan A. van de Loosdrecht
Author_xml – sequence: 1
  givenname: Saskia J. A. M.
  surname: Santegoets
  fullname: Santegoets, Saskia J. A. M.
– sequence: 2
  givenname: Alfons J. M.
  surname: Eertwegh
  fullname: Eertwegh, Alfons J. M.
– sequence: 3
  givenname: Arjan A.
  surname: Loosdrecht
  fullname: Loosdrecht, Arjan A.
– sequence: 4
  givenname: Rik J.
  surname: Scheper
  fullname: Scheper, Rik J.
  email: rj.scheper@vumc.nl
– sequence: 5
  givenname: Tanja D.
  surname: Gruijl
  fullname: Gruijl, Tanja D.
BackLink https://www.ncbi.nlm.nih.gov/pubmed/18664532$$D View this record in MEDLINE/PubMed
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Snippet Dendritic cells (DC) are increasingly applied in the immunotherapy of cancer. As the development of a standardized DC vaccine product is often hampered by the...
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StartPage 1364
SubjectTerms biology
Cancer Vaccines - therapeutic use
Cell Differentiation - physiology
Cell Line
Dendritic Cells - physiology
Humans
immunotherapy
interstitial
Langerhans cell
Leukemia - immunology
Leukemia - therapy
Models, Biological
MUTZ‐3
Title Human dendritic cell line models for DC differentiation and clinical DC vaccination studies
URI http://www.jleukbio.org/content/84/6/1364.abstract
https://onlinelibrary.wiley.com/doi/abs/10.1189%2Fjlb.0208092
https://www.ncbi.nlm.nih.gov/pubmed/18664532
https://www.proquest.com/docview/20970890
https://www.proquest.com/docview/69814842
Volume 84
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