Normal cerebral perfusion measurements using arterial spin labeling: Reproducibility, stability, and age and gender effects

Before meaningful conclusions can be drawn from clinical measures of cerebral blood perfusion, the precision of the measurement must be determined and set in the context of inter‐ and intrasubject sources of variability. This work establishes the reproducibility of perfusion measurements using the n...

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Vydáno v:Magnetic resonance in medicine Ročník 51; číslo 4; s. 736 - 743
Hlavní autoři: Parkes, Laura M., Rashid, Waqar, Chard, Declan T., Tofts, Paul S.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.04.2004
Témata:
Adult
age
Age Factors
Aged
arterial spin labeling
Brain - blood supply
Cerebral Arteries - physiology
cerebral perfusion
Cerebrovascular Circulation - physiology
Female
Follow-Up Studies
Frontal Lobe - blood supply
gender
Humans
Image Enhancement - methods
Linear Models
Magnetic Resonance Imaging - methods
Male
Middle Aged
Parietal Lobe - blood supply
reproducibility
Reproducibility of Results
Sex Factors
Spin Labels
ISSN:0740-3194, 1522-2594
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Shrnutí:Before meaningful conclusions can be drawn from clinical measures of cerebral blood perfusion, the precision of the measurement must be determined and set in the context of inter‐ and intrasubject sources of variability. This work establishes the reproducibility of perfusion measurements using the noninvasive MRI technique of continuous arterial spin labeling (CASL). Perfusion was measured in 34 healthy normal subjects. Intersubject variability was assessed, and age and gender contributions were estimated. Intersubject variation was found to be large, with up to 100% perfusion difference for subjects of the same age and gender. Repeated measurements in one subject showed that perfusion remains remarkably stable in the short term when compared with intersubject variation and the large capacity for perfusion change in the brain. A significant decrease in the ratio of gray‐matter to white‐matter perfusion was found with increasing age (0.79% per year (P < 0.0005)). This appears to be due mainly to a reduction in gray‐matter perfusion, which was found to decrease by 0.45% per year (P = 0.04). Regional analysis suggested that the gray‐matter age‐related changes were predominantly localized in the frontal cortex. Whole‐brain perfusion was 13% higher (P = 0.02) in females compared to males. Magn Reson Med 51:736–743, 2004. © 2004 Wiley‐Liss, Inc.
Bibliografie:ark:/67375/WNG-2RN7XJRD-F
Schering AG
istex:C9768B46CE80DF6CFF62828670FC16C8BD8E0841
MS Society of Great Britain and Northern Ireland
Brain Research Trust UK
ArticleID:MRM20023
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0740-3194
1522-2594
DOI:10.1002/mrm.20023