UNC93B1 mediates differential trafficking of endosomal TLRs

UNC93B1, a multipass transmembrane protein required for TLR3, TLR7, TLR9, TLR11, TLR12, and TLR13 function, controls trafficking of TLRs from the endoplasmic reticulum (ER) to endolysosomes. The mechanisms by which UNC93B1 mediates these regulatory effects remain unclear. Here, we demonstrate that U...

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Bibliographic Details
Published in:	eLife Vol. 2; p. e00291
Main Authors:	Lee, Bettina L, Moon, Joanne E, Shu, Jeffrey H, Yuan, Lin, Newman, Zachary R, Schekman, Randy, Barton, Gregory M
Format:	Journal Article
Language:	English
Published:	England eLife Sciences Publications Ltd 19.02.2013 eLife Sciences Publications, Ltd
Subjects:	Adaptor Protein Complex 2 - metabolism Animals AP-2 Autoimmune diseases Biology Cell Biology Cercopithecus aethiops COP-Coated Vesicles - metabolism COS Cells Deoxyribonucleic acid DNA Endoplasmic reticulum Endoplasmic Reticulum - metabolism Endosomes - metabolism Golgi apparatus Golgi Apparatus - metabolism HEK293 Cells Humans Immunology Ligands Localization Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Mice, Inbred C57BL Mice, Transgenic Mutation Protein Transport Proteins RNA Interference TLR3 protein TLR7 protein TLR9 protein Toll-like receptor Toll-like receptors Toll-Like Receptors - genetics Toll-Like Receptors - metabolism trafficking Transfection UNC93B1 Yeast Toll-like receptors AP-2 Mouse UNC93B1 trafficking
ISSN:	2050-084X, 2050-084X
Online Access:	Get full text
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