Mathematical modelling reveals compound-specific stress pathway activity

Drug-induced liver injury (DILI) is a major problem for the drug development industry. It has been suggested that activation of stress pathways within cells is an important indicator of DILI. In this project, we aimed to develop a mathematical model of invoked stress responses by three compounds wit...

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Veröffentlicht in:	Toxicology (Amsterdam) Jg. 518; S. 154234
Hauptverfasser:	Burgers, Elsje J., Danilyuk, Tamara Y., Sharma, Raju P., Renner, Nadine, Verlohner, Andreas, Rocker, Nicole, Ternes, Philipp, Wijaya, Lukas S., Leist, Marcel, Bouwman, Peter, Zickgraf, Franziska M., Schildknecht, Stefan, van de Water, Bob, Beltman, Joost B.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Ireland Elsevier B.V 01.12.2025
Schlagworte:	Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - metabolism Diclofenac - toxicity DILI Emergency Glutathione - metabolism Hep G2 Cells Humans Integrated stress response Ketoconazole - toxicity Mathematical modelling Models, Biological Nitrofurantoin - toxicity Oxidative Stress - drug effects Oxidative stress response Pharmacology/Toxicology Signal Transduction - drug effects DILI Mathematical modelling Integrated stress response Oxidative stress response
ISSN:	0300-483X, 1879-3185, 1879-3185
Online-Zugang:	Volltext
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