Sequential Infection with Common Pathogens Promotes Human-like Immune Gene Expression and Altered Vaccine Response

Immune responses differ between laboratory mice and humans. Chronic infection with viruses and parasites are common in humans, but are absent in laboratory mice, and thus represent potential contributors to inter-species differences in immunity. To test this, we sequentially infected laboratory mice...

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Veröffentlicht in:	Cell host & microbe Jg. 19; H. 5; S. 713
Hauptverfasser:	Reese, Tiffany A, Bi, Kevin, Kambal, Amal, Filali-Mouhim, Ali, Beura, Lalit K, Bürger, Matheus C, Pulendran, Bali, Sekaly, Rafick-Pierre, Jameson, Stephen C, Masopust, David, Haining, W Nicholas, Virgin, Herbert W
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 11.05.2016
Schlagworte:	Animals Antibodies - blood Antibodies, Viral - immunology Coinfection - immunology Coinfection - parasitology Coinfection - virology Cytokines - blood Disease Models, Animal Fetal Blood - immunology Gene Expression Helminthiasis - immunology Helminthiasis - prevention & control Helminthiasis - virology Herpesviridae - immunology Herpesviridae Infections - immunology Herpesviridae Infections - prevention & control Humans Immunity, Innate Immunoglobulin G - blood Influenza, Human - immunology Influenza, Human - prevention & control Intestinal Diseases, Parasitic - immunology Intestinal Diseases, Parasitic - prevention & control Intestinal Diseases, Parasitic - virology Mice Mice, Inbred C57BL Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - parasitology Orthomyxoviridae Infections - prevention & control Yellow Fever - immunology Yellow Fever - parasitology Yellow Fever - prevention & control Yellow Fever - virology Yellow Fever Vaccine - immunology Yellow Fever Vaccine - pharmacology Yellow fever virus - immunology
ISSN:	1934-6069, 1934-6069
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Beschreibung
Zusammenfassung:	Immune responses differ between laboratory mice and humans. Chronic infection with viruses and parasites are common in humans, but are absent in laboratory mice, and thus represent potential contributors to inter-species differences in immunity. To test this, we sequentially infected laboratory mice with herpesviruses, influenza, and an intestinal helminth and compared their blood immune signatures to mock-infected mice before and after vaccination against yellow fever virus (YFV-17D). Sequential infection altered pre- and post-vaccination gene expression, cytokines, and antibodies in blood. Sequential pathogen exposure induced gene signatures that recapitulated those seen in blood from pet store-raised versus laboratory mice, and adult versus cord blood in humans. Therefore, basal and vaccine-induced murine immune responses are altered by infection with agents common outside of barrier facilities. This raises the possibility that we can improve mouse models of vaccination and immunity by selective microbial exposure of laboratory animals to mimic that of humans.
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1934-6069 1934-6069
DOI:	10.1016/j.chom.2016.04.003