Brazilian stingless bee propolis and geopropolis: promising sources of biologically active compounds

[Display omitted] Stingless bee products such as honey, pollen, propolis, and geopropolis have been used for centuries in traditional medicine for the treatment of several illnesses. Investigation of the biological activity of stingless bee products, especially propolis and geopropolis, has revealed...

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Veröffentlicht in:	Revista brasileira de farmacognosia Jg. 29; H. 3; S. 389 - 399
Hauptverfasser:	Lavinas, Flavia C., Macedo, Ellis Helena B.C., Sá, Gabriel B.L., Amaral, Ana Claudia F., Silva, Jefferson R.A., Azevedo, Mariana M.B., Vieira, Bárbara A., Domingos, Thaisa Francielle S., Vermelho, Alane B., Carneiro, Carla S., Rodrigues, Igor A.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Cham Elsevier Editora Ltda 01.05.2019 Springer International Publishing Sociedade Brasileira de Farmacognosia
Schlagworte:	antimicrobial properties antioxidant activity antioxidants bioactive compounds Biological activity Brazil Brazilian stingless bee Chemical composition computer software ethanol Geopropolis honey medicinal properties PHARMACOLOGY & PHARMACY Pharmacy pollen Propolis Review species diversity stingless bees toxicity traditional medicine Brazil Chemical composition Brazilian stingless bee Propolis Geopropolis Biological activity
ISSN:	0102-695X, 1981-528X, 1981-528X
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Abstract	[Display omitted] Stingless bee products such as honey, pollen, propolis, and geopropolis have been used for centuries in traditional medicine for the treatment of several illnesses. Investigation of the biological activity of stingless bee products, especially propolis and geopropolis, has revealed promising therapeutic properties. About 20% of total Neotropical stingless bees can be found in Brazil. Despite the species diversity, studies on their biological activity are scarce. The present review focuses on the antioxidant and antimicrobial activities of propolis and geopropolis from Brazilian stingless bees. In addition, the toxicity of these natural products was addressed. In order to provide new evidences for the toxic potential of propolis and geopropolis components, an in silico analysis was performed using the ADMET PredictorTM software. We observed that most of studies evaluated only crude ethanol extracts of a limited number of stingless bees species. Propolis and geopropolis displayed antioxidant capacity and antimicrobial activity. Concerning the toxic potential, the extracts of stingless bees propolis and geopropolis were considered safe. Nonetheless, in vitro and in vivo toxicological studies are still necessary.
AbstractList	[Display omitted] Stingless bee products such as honey, pollen, propolis, and geopropolis have been used for centuries in traditional medicine for the treatment of several illnesses. Investigation of the biological activity of stingless bee products, especially propolis and geopropolis, has revealed promising therapeutic properties. About 20% of total Neotropical stingless bees can be found in Brazil. Despite the species diversity, studies on their biological activity are scarce. The present review focuses on the antioxidant and antimicrobial activities of propolis and geopropolis from Brazilian stingless bees. In addition, the toxicity of these natural products was addressed. In order to provide new evidences for the toxic potential of propolis and geopropolis components, an in silico analysis was performed using the ADMET PredictorTM software. We observed that most of studies evaluated only crude ethanol extracts of a limited number of stingless bees species. Propolis and geopropolis displayed antioxidant capacity and antimicrobial activity. Concerning the toxic potential, the extracts of stingless bees propolis and geopropolis were considered safe. Nonetheless, in vitro and in vivo toxicological studies are still necessary. Stingless bee products such as honey, pollen, propolis, and geopropolis have been used for centuries in traditional medicine for the treatment of several illnesses. Investigation of the biological activity of stingless bee products, especially propolis and geopropolis, has revealed promising therapeutic properties. About 20% of total Neotropical stingless bees can be found in Brazil. Despite the species diversity, studies on their biological activity are scarce. The present review focuses on the antioxidant and antimicrobial activities of propolis and geopropolis from Brazilian stingless bees. In addition, the toxicity of these natural products was addressed. In order to provide new evidences for the toxic potential of propolis and geopropolis components, an in silico analysis was performed using the ADMET Predictor™ software. We observed that most of studies evaluated only crude ethanol extracts of a limited number of stingless bees species. Propolis and geopropolis displayed antioxidant capacity and antimicrobial activity. Concerning the toxic potential, the extracts of stingless bees propolis and geopropolis were considered safe. Nonetheless, in vitro and in vivo toxicological studies are still necessary. ABSTRACT Stingless bee products such as honey, pollen, propolis, and geopropolis have been used for centuries in traditional medicine for the treatment of several illnesses. Investigation of the biological activity of stingless bee products, especially propolis and geopropolis, has revealed promising therapeutic properties. About 20% of total Neotropical stingless bees can be found in Brazil. Despite the species diversity, studies on their biological activity are scarce. The present review focuses on the antioxidant and antimicrobial activities of propolis and geopropolis from Brazilian stingless bees. In addition, the toxicity of these natural products was addressed. In order to provide new evidences for the toxic potential of propolis and geopropolis components, an in silico analysis was performed using the ADMET PredictorTM software. We observed that most of studies evaluated only crude ethanol extracts of a limited number of stingless bees species. Propolis and geopropolis displayed antioxidant capacity and antimicrobial activity. Concerning the toxic potential, the extracts of stingless bees propolis and geopropolis were considered safe. Nonetheless, in vitro and in vivo toxicological studies are still necessary. Stingless bee products such as honey, pollen, propolis, and geopropolis have been used for centuries in traditional medicine for the treatment of several illnesses. Investigation of the biological activity of stingless bee products, especially propolis and geopropolis, has revealed promising therapeutic properties. About 20% of total Neotropical stingless bees can be found in Brazil. Despite the species diversity, studies on their biological activity are scarce. The present review focuses on the antioxidant and antimicrobial activities of propolis and geopropolis from Brazilian stingless bees. In addition, the toxicity of these natural products was addressed. In order to provide new evidences for the toxic potential of propolis and geopropolis components, an in silico analysis was performed using the ADMET PredictorTM software. We observed that most of studies evaluated only crude ethanol extracts of a limited number of stingless bees species. Propolis and geopropolis displayed antioxidant capacity and antimicrobial activity. Concerning the toxic potential, the extracts of stingless bees propolis and geopropolis were considered safe. Nonetheless, in vitro and in vivo toxicological studies are still necessary.
Author	Silva, Jefferson R.A. Vieira, Bárbara A. Rodrigues, Igor A. Amaral, Ana Claudia F. Lavinas, Flavia C. Sá, Gabriel B.L. Azevedo, Mariana M.B. Macedo, Ellis Helena B.C. Vermelho, Alane B. Carneiro, Carla S. Domingos, Thaisa Francielle S.
AuthorAffiliation	Farmanguinhos Fiocruz Universidade Federal do Rio de Janeiro Universidade Federal do Amazonas
AuthorAffiliation_xml	– name: Farmanguinhos Fiocruz – name: Universidade Federal do Amazonas – name: Universidade Federal do Rio de Janeiro
Author_xml	– sequence: 1 givenname: Flavia C. surname: Lavinas fullname: Lavinas, Flavia C. organization: Programa de Pós-graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil – sequence: 2 givenname: Ellis Helena B.C. surname: Macedo fullname: Macedo, Ellis Helena B.C. organization: Programa de Pós-graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil – sequence: 3 givenname: Gabriel B.L. surname: Sá fullname: Sá, Gabriel B.L. organization: Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil – sequence: 4 givenname: Ana Claudia F. surname: Amaral fullname: Amaral, Ana Claudia F. email: acamaral@fiocruz.br organization: Departamento de Produtos Naturais, Farmanguinhos Fiocruz, Rio de Janeiro, RJ, Brazil – sequence: 5 givenname: Jefferson R.A. surname: Silva fullname: Silva, Jefferson R.A. organization: Departamento of Química, Universidade Federal do Amazonas, Manaus, AM, Brazil – sequence: 6 givenname: Mariana M.B. surname: Azevedo fullname: Azevedo, Mariana M.B. organization: Departamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil – sequence: 7 givenname: Bárbara A. surname: Vieira fullname: Vieira, Bárbara A. organization: Departamento de Fármacos e Medicamentos, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil – sequence: 8 givenname: Thaisa Francielle S. surname: Domingos fullname: Domingos, Thaisa Francielle S. organization: Departamento de Fármacos e Medicamentos, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil – sequence: 9 givenname: Alane B. surname: Vermelho fullname: Vermelho, Alane B. organization: Departamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil – sequence: 10 givenname: Carla S. surname: Carneiro fullname: Carneiro, Carla S. organization: Departamento de Produtos Naturais e Alimentos, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil – sequence: 11 givenname: Igor A. surname: Rodrigues fullname: Rodrigues, Igor A. organization: Programa de Pós-graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
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ContentType	Journal Article
Copyright	2018 Published by Elsevier Editora Ltda. on behalf of Sociedade Brasileira de Farmacognosia 2018 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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Keywords	Chemical composition Brazilian stingless bee Propolis Geopropolis Biological activity
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62 Parthasarathi, Dhawan (bib0260) 2018 Raies, Bajic (bib0285) 2016; 6 Kujumgiev, Tsvetkova, Serkedjieva, Bankova, Christov, Popov (bib0190) 1999; 64 Sawaya, da Silva Cunha, Marcucci (bib0335) 2011; 5 Mishra, Ojha, Chaudhury (bib0240) 2012; 130 Barth, Luz (bib0050) 2003; 42 Mercan, Kivrak, Duru, Katircioglu, Gulcan, Malci, Acar, Salih (bib0225) 2006; 56 Sawaya, Cunha, Marcucci, Rodrigues, Eberlin (bib0330) 2006; 37 Araújo, Santos Júnior, Sato, Finco, Soares, Barbosa, Alvim, Ascêncio, Mariano (bib0010) 2016; 46 Guzmán-Gutiérrez, Nieto-Camacho, Castillo-Arellano, Huerta-Salazar, Hernández-Pasteur, Silva-Miranda, Argüello-Nájera, Sepúlveda-Robles, Espitia, Reyes-Chilpa (bib0175) 2018; 23 Pedro (bib0270) 2014; 61 Zhu, Chen, Shou, Li, Hu (bib0395) 2011 de Souza, da Silva, da Silva, Camara, Silva (bib0115) 2018; 29 Santos, Hochheim, Boeder, Kroger, Tomazzoli, Neto, Maraschin, Guedes, Cordova (bib0310) 2017; 56 Santos, Campos, Santos, Balestieri, Silva, Carollo, de Picoli Souza, Estevinho, dos Santos (bib0305) 2017; 18 Cisilotto, Sandjo, Faqueti, Fernandes, Joppi, Biavatti, Creczynski-Pasa (bib0095) 2017; 149 Rajabi, Ramazani, Hamidi, Naji (bib0290) 2015; 23 Mushtaq, Das, Aksoy (bib0250) 2018; 38 Bankova, Popova, Trusheva (bib0035) 2014; 8 Cao, Chen, Zhang, You, Wang, Hu (bib0090) 2017; 34 Parasuraman (bib0255) 2011; 2 Sawaya, Calado, dos Santos, Marcucci, Akatsu, Soares, Abdelnur, Cunha, Eberlin (bib0320) 2009; 1 Coelho, Mendonça, Vilar, Figueiredo, Badari, Taniwaki, Namiyama, Oliveira, Curti, Silva, Negri (bib0100) 2015 Miorin, Levy Junior, Bretz, Marcucci (bib0235) 2003; 95 Campos, dos Santos, da Rocha, Damião, Balestieri, Cardoso, Paredes-Gamero, Estevinho, Souza, Santos (bib0075) 2015 Landim (bib0200) 2009 Velikova, Bankova, Marcucci, Tsvetkova, Kujumgiev (bib0375) 2000; 55 Lee, Boontaveeyuwat, Thaiwat, Rustin, McFadden (bib0205) 2018; 79 Shahidi, Ambigaipalan (bib0340) 2015; 18B Velikova, Bankova, Tsvetkova, Kujumgiev, Marcucci (bib0380) 2000; 71 Bartolomeu, Frión-Herrera, da Silva, Romagnoli, de Oliveira, Sforcin (bib0055) 2016; 81 Fianco, Falcão, Cassel, Milão (bib0160) 2013; 14 Molnár, Mikuska, Patonay, Sisa, Daood, Némedi, Kiss (bib0245) 2017; 23 Boekelheide, Brent, Charnley, Cheung (bib0060) 2015; 13 Cao, Chen, Zhang, You, Wang, Hu (CR18) 2017; 34 Boekelheide, Brent, Charnley, Cheung (CR12) 2015; 13 Bonamigo, Campos, Alfredo, Balestieri, Cardoso, Paredes-Gamero, Souza, Santos (CR14) 2017 Zhu, Chen, Shou, Li, Hu (CR79) 2011 Hrncir, Jarau, Barth (CR36) 2016; 202 Michener, Vit, Pedro, Roubik (CR46) 2013 Valente, Baltazar, Henrique, Estevinho, Carvalho (CR73) 2011; 49 Bartolomeu, Frión-Herrera, da Silva, Romagnoli, de Oliveira, Sforcin (CR11) 2016; 81 Campos, Santos, Macorini, Mestriner, Balestieri, Gamero, Cardoso, Souza, dos Santos (CR16) 2014; 65 Mushtaq, Das, Aksoy (CR50) 2018; 38 Sawaya, Cunha, Marcucci, Aidar, Silva, Carvalho, Eberlin (CR65) 2007; 38 Ranganatha, Kuppast (CR59) 2012; 4 Jaffé, Pope, Torres Carvalho, Maia, Blochtein, de Carvalho, Carvalho-Zilse, Freitas, Menezes, Ribeiro, Venturieri, Imperatriz-Fonseca (CR37) 2015; 10 Campos, Júnior, Oliveira, Carvalho, Machado, Tirelli (CR17) 2011; 35 Arora, Mehta, Joshi, Mehta, Rathor, Mediratta, Sharma (CR6) 2011; 73 Bankova, Christov, Popov, Marcucci, Tsvetkova (CR9) 1999; 70 Maia Filho, Maia, de CR, Bastos, Novais (CR44) 2008; 56 Araújo, Bufalo, Trusheva, Bankova, Sforcin (CR4) 2015; 4 Villas-Bôas (CR77) 2012 Cunha, Franchin, Galvõ, de Ruiz, de Carvalho, Ikegaki, Alencar, Koo, Rosalen (CR21) 2013; 13 Miorin, Levy Junior, Bretz, Marcucci (CR47) 2003; 95 Deeb, Goodarzi (CR24) 2012; 7 Fianco, Falcão, Cassel, Milão (CR32) 2013; 14 Patricio, Cruz-López, Maile, Tentschert, Jones, Morgan (CR53) 2002; 48 Valerio (CR74) 2009; 241 Freitas, Ponte, Silveira (CR33) 2008; 19 Barth, Luz (CR10) 2003; 42 Torres, Sandjo, Friedemann, Tomazzoli, Maraschin, Mello, Santos (CR72) 2018; 51 Sawaya, Calado, dos Santos, Marcucci, Akatsu, Soares, Abdelnur, Cunha, Eberlin (CR64) 2009; 1 CR7 Ferreira, Fernandes-Silva, Salatino, Message, Negri (CR31) 2018 Santos, Hochheim, Boeder, Kroger, Tomazzoli, Neto, Maraschin, Gliedes, Cordova (CR62) 2017; 56 Zeng, Jiang (CR78) 2010; 159 Fang, Yang, Wu (CR28) 2002; 18 Souza, da Silva, Cordeiro, Filho, da Silva, Reis, Porto, Pilau, de Souza, Menezes, Flachauim (CR70) 2018; 41 Guzmán-Gutiérrez, Nieto-Camacho, Castillo-Arellano, Huerta-Salazar, Hernández-Pasteur, Silva-Miranda, Argüello-Nájera, Sepúlveda-Robles, Espitia, Reyes-Chilpa (CR35) 2018; 23 Kujumgiev, Tsvetkova, Serkedjieva, Bankova, Christov, Popov (CR38) 1999; 64 López-Alarcón, Denicola (CR43) 2013; 763 Peter, Picoli, Zani, Latosinski, Lima, Vargas, Hübner, Fischer (CR56) 2017; 37 dos Santos, Hochheim, Boeder, Kroger, Tomazzoli, Dal Pai Neto, Maraschin, Guedes, de Cordova (CR25) 2017; 56 Molnár, Mikuska, Patonay, Sisa, Daood, Némedi, Kiss (CR49) 2017; 23 Cunha, Rosalen, Franchin, de Alencar, Ikegaki, Ransom, Beutler (CR22) 2015; 82 Dutra, Abreu, Cunha, Torres, Nascimento, Ribeiro, Guerra (CR27) 2014; 62 Santos, Queiroz, Sawaya, Lopez, Soares, Bezerra, Rodrigues, de Paula, Waldschmidt (CR63) 2017; 89 Velikova, Bankova, Marcucci, Tsvetkova, Kujumgiev (CR75) 2000; 55 Coelho, Mendonça, Vilar, Figueiredo, Badari, Taniwaki, Namiyama, Oliveira, Curti, Silva, Negri (CR20) 2015 Lee, Boontaveeyuwat, Thaiwat, Rustin, McFadden (CR41) 2018; 79 Bonamigo, Campo, Oliveira, Torquato, Balestieri, Cardoso, Paredes-Gamero, Souza, Santos (CR13) 2017; 12 Felipe Neto (CR29) 2015 Silva, Muniz, Nunomura, Nunomura, Zilse (CR69) 2013; 36 de Souza, da Silva, da Silva, Camara, Silva (CR23) 2018; 29 Fernandes, Leomil, Fernandes, Sforcin (CR30) 2001; 7 Raies, Bajic (CR57) 2016; 6 Araújo, Mattar, Reis, Serra, Fialho, Assunçáo, Dutra, Nogueira, Libério, Guerra, Lopes, Ribeiro, Nascimento (CR5) 2011; 25 CR58 Sawaya, Cunha, Marcucci, Rodrigues, Eberlin (CR66) 2006; 37 Velikova, Bankova, Tsvetkova, Kujumgiev, Marcucci (CR76) 2000; 71 Cisilotto, Sandjo, Faqueti, Fernandes, Joppi, Biavatti, Creczynski-Pasa (CR19) 2017; 149 Mishra, Ojha, Chaudhury (CR48) 2012; 130 Parasuraman (CR51) 2011; 2 Gastauer, Campos, Wittmann (CR34) 2011; 55 Acharyya, Patra, Bag (CR1) 2009; 8 Pedro (CR54) 2014; 61 Shahidi, Ambigaipalan (CR68) 2015; 18B Araújo, Santos Júnior, Sato, Finco, Soares, Barbosa, Alvim, Ascêndo, Mariano (CR2) 2016; 46 Parthasarathi, Dhawan, Dhawan, Kwon (CR52) 2018 Souza, Camara, Silva, Silva (CR71) 2013 Landim (CR40) 2009 Santos, Campos, Santos, Balestieri, Silva, Carollo, Souza, Estevinho, dos Santos (CR61) 2017; 18 Campos, dos Santos, da Rocha, Damião, Balestieri, Cardoso, Paredes-Gamero, Estevinho, Souza, Santos (CR15) 2015 Kustiawan, Phuwapraisirisan, Puthong, Palaga, Arung, Chanchao (CR39) 2015; 16 Pereira, Bicalho, Neto (CR55) 2003; 34 Mercan, Kivrak, Duru, Katircioglu, Gulcan, Malci, Acar, Salih (CR45) 2006; 56 CR67 Bankova, Christov, Marcucci, Popov (CR8) 1998; 53 CR60 Dut hie, Gardner, Kyle (CR26) 2003; 62 Araújo, Bosco, Sforcin (CR3) 2016; 47 Liberio, Pereira, Dutra, Reis, Araújo, Mattar, Ribeiro, Nascimento, Guerra, Monteiro-Neto (CR42) 2011; 11 Valerio (10.1016/j.bjp.2018.11.007_bib0370) 2009; 241 Torres (10.1016/j.bjp.2018.11.007_bib0360) 2018; 51 Araújo (10.1016/j.bjp.2018.11.007_bib0015) 2016; 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Snippet	[Display omitted] Stingless bee products such as honey, pollen, propolis, and geopropolis have been used for centuries in traditional medicine for the... Stingless bee products such as honey, pollen, propolis, and geopropolis have been used for centuries in traditional medicine for the treatment of several... ABSTRACT Stingless bee products such as honey, pollen, propolis, and geopropolis have been used for centuries in traditional medicine for the treatment of...
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SubjectTerms	antimicrobial properties antioxidant activity antioxidants bioactive compounds Biological activity Brazil Brazilian stingless bee Chemical composition computer software ethanol Geopropolis honey medicinal properties PHARMACOLOGY & PHARMACY Pharmacy pollen Propolis Review species diversity stingless bees toxicity traditional medicine
Title	Brazilian stingless bee propolis and geopropolis: promising sources of biologically active compounds
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