Brazilian stingless bee propolis and geopropolis: promising sources of biologically active compounds

[Display omitted] Stingless bee products such as honey, pollen, propolis, and geopropolis have been used for centuries in traditional medicine for the treatment of several illnesses. Investigation of the biological activity of stingless bee products, especially propolis and geopropolis, has revealed...

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Veröffentlicht in:Revista brasileira de farmacognosia Jg. 29; H. 3; S. 389 - 399
Hauptverfasser: Lavinas, Flavia C., Macedo, Ellis Helena B.C., Sá, Gabriel B.L., Amaral, Ana Claudia F., Silva, Jefferson R.A., Azevedo, Mariana M.B., Vieira, Bárbara A., Domingos, Thaisa Francielle S., Vermelho, Alane B., Carneiro, Carla S., Rodrigues, Igor A.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Cham Elsevier Editora Ltda 01.05.2019
Springer International Publishing
Sociedade Brasileira de Farmacognosia
Schlagworte:
antimicrobial properties
antioxidant activity
antioxidants
bioactive compounds
Biological activity
Brazil
Brazilian stingless bee
Chemical composition
computer software
ethanol
Geopropolis
honey
medicinal properties
PHARMACOLOGY & PHARMACY
Pharmacy
pollen
Propolis
Review
species diversity
stingless bees
toxicity
traditional medicine
Brazil
Chemical composition
Brazilian stingless bee
Propolis
Geopropolis
Biological activity
ISSN:0102-695X, 1981-528X, 1981-528X
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Zusammenfassung:[Display omitted] Stingless bee products such as honey, pollen, propolis, and geopropolis have been used for centuries in traditional medicine for the treatment of several illnesses. Investigation of the biological activity of stingless bee products, especially propolis and geopropolis, has revealed promising therapeutic properties. About 20% of total Neotropical stingless bees can be found in Brazil. Despite the species diversity, studies on their biological activity are scarce. The present review focuses on the antioxidant and antimicrobial activities of propolis and geopropolis from Brazilian stingless bees. In addition, the toxicity of these natural products was addressed. In order to provide new evidences for the toxic potential of propolis and geopropolis components, an in silico analysis was performed using the ADMET PredictorTM software. We observed that most of studies evaluated only crude ethanol extracts of a limited number of stingless bees species. Propolis and geopropolis displayed antioxidant capacity and antimicrobial activity. Concerning the toxic potential, the extracts of stingless bees propolis and geopropolis were considered safe. Nonetheless, in vitro and in vivo toxicological studies are still necessary.
Bibliographie:ObjectType-Article-1
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ObjectType-Feature-2
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ISSN:0102-695X
1981-528X
1981-528X
DOI:10.1016/j.bjp.2018.11.007