Tetraploidization of Immortalized Myoblasts Induced by Cell Fusion Drives Myogenic Sarcoma Development with DMD Deletion

Whole-genome doubling is the second most frequent genomic event, after TP53 alterations, in advanced solid tumors and is associated with poor prognosis. Tetraploidization step will lead to aneuploidy and chromosomic rearrangements. The mechanism leading to tetraploid cells is important since endorep...

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Veröffentlicht in:	Cancers Jg. 12; H. 5; S. 1281
Hauptverfasser:	Merle, Candice, Thébault, Noémie, LeGuellec, Sophie, Baud, Jessica, Pérot, Gaëlle, Lesluyes, Tom, Delespaul, Lucile, Lartigue, Lydia, Chibon, Frédéric
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland MDPI AG 19.05.2020 MDPI
Schlagworte:	Aneuploidy Cancer Cell activation Cell fusion Chromosomes Cloning Cytokinesis Deoxyribonucleic acid DNA Genomes Hybrids Hypotheses Invasiveness Life Sciences Metastases Mitosis Myoblasts p53 Protein Physiology Population Sarcoma Solid tumors Tumorigenesis Tumors sarcoma dystrophin genomic instability cell fusion
ISSN:	2072-6694, 2072-6694
Online-Zugang:	Volltext
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