Analyzing In Silico the Relationship Between the Activation of the Edema Factor and Its Interaction With Calmodulin

Molecular dynamics (MD) simulations have been recorded on the complex between the edema factor (EF) of Bacilllus anthracis and calmodulin (CaM), starting from a structure with the orthosteric inhibitor adefovir bound in the EF catalytic site. The starting structure has been destabilized by alternate...

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Vydané v:	Frontiers in molecular biosciences Ročník 7; s. 586544
Hlavní autori:	Pitard, Irène, Monet, Damien, Goossens, Pierre L., Blondel, Arnaud, Malliavin, Thérèse E.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Switzerland Frontiers Media 04.12.2020 Frontiers Media S.A
Predmet:	allostery Bacillus anthracis Biochemistry, Molecular Biology Bioinformatics Biophysics Cavity detection Computer Science Life Sciences Molecular Biosciences protein-protein interaction Structural Biology virulence factor Bacillus anthracis protein-protein interaction virulence factor Cavity detection allostery
ISSN:	2296-889X, 1662-5099, 2296-889X, 1662-5099
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