NAD + Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair

Ataxia telangiectasia (A-T) is a rare autosomal recessive disease characterized by progressive neurodegeneration and cerebellar ataxia. A-T is causally linked to defects in ATM, a master regulator of the response to and repair of DNA double-strand breaks. The molecular basis of cerebellar atrophy an...

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Bibliographic Details
Published in:	Cell metabolism Vol. 24; no. 4; p. 566
Main Authors:	Fang, Evandro Fei, Kassahun, Henok, Croteau, Deborah L, Scheibye-Knudsen, Morten, Marosi, Krisztina, Lu, Huiming, Shamanna, Raghavendra A, Kalyanasundaram, Sumana, Bollineni, Ravi Chand, Wilson, Mark A, Iser, Wendy B, Wollman, Bradley N, Morevati, Marya, Li, Jun, Kerr, Jesse S, Lu, Qiping, Waltz, Tyler B, Tian, Jane, Sinclair, David A, Mattson, Mark P, Nilsen, Hilde, Bohr, Vilhelm A
Format:	Journal Article
Language:	English
Published:	United States 11.10.2016
Subjects:	Animals Ataxia Telangiectasia - pathology Ataxia Telangiectasia Mutated Proteins - deficiency Ataxia Telangiectasia Mutated Proteins - metabolism Behavior, Animal Caenorhabditis elegans - metabolism Caenorhabditis elegans - ultrastructure Cells, Cultured Disease Models, Animal DNA Repair - drug effects Gene Knockdown Techniques Health Homeostasis - drug effects Longevity - drug effects Metabolomics Mice Mitophagy - drug effects NAD - pharmacology Neurons - drug effects Neurons - metabolism Phenotype Phthalazines - pharmacology Piperazines - pharmacology Proteomics Rats, Sprague-Dawley Signal Transduction - drug effects Sirtuin 1 - metabolism
ISSN:	1932-7420, 1932-7420
Online Access:	Get more information
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