Integration of rare expression outlier-associated variants improves polygenic risk prediction

Polygenic risk scores (PRSs) quantify the contribution of multiple genetic loci to an individual's likelihood of a complex trait or disease. However, existing PRSs estimate this likelihood with common genetic variants, excluding the impact of rare variants. Here, we report on a method to identi...

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Bibliographic Details

Published in:	American journal of human genetics Vol. 109; no. 6; p. 1055
Main Authors:	Smail, Craig, Ferraro, Nicole M, Hui, Qin, Durrant, Matthew G, Aguirre, Matthew, Tanigawa, Yosuke, Keever-Keigher, Marissa R, Rao, Abhiram S, Justesen, Johanne M, Li, Xin, Gloudemans, Michael J, Assimes, Themistocles L, Kooperberg, Charles, Reiner, Alexander P, Huang, Jie, O'Donnell, Christopher J, Sun, Yan V, Rivas, Manuel A, Montgomery, Stephen B
Format:	Journal Article
Language:	English
Published:	United States 02.06.2022
Subjects:	Body Mass Index Genetic Predisposition to Disease Genome-Wide Association Study Humans Multifactorial Inheritance - genetics Obesity - genetics Phenotype Risk Factors rare variants transcriptomics complex disease obesity BMI polygenic risk scores
ISSN:	1537-6605, 1537-6605
Online Access:	Get more information
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