Integration of rare expression outlier-associated variants improves polygenic risk prediction

Polygenic risk scores (PRSs) quantify the contribution of multiple genetic loci to an individual's likelihood of a complex trait or disease. However, existing PRSs estimate this likelihood with common genetic variants, excluding the impact of rare variants. Here, we report on a method to identi...

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Vydáno v:	American journal of human genetics Ročník 109; číslo 6; s. 1055
Hlavní autoři:	Smail, Craig, Ferraro, Nicole M, Hui, Qin, Durrant, Matthew G, Aguirre, Matthew, Tanigawa, Yosuke, Keever-Keigher, Marissa R, Rao, Abhiram S, Justesen, Johanne M, Li, Xin, Gloudemans, Michael J, Assimes, Themistocles L, Kooperberg, Charles, Reiner, Alexander P, Huang, Jie, O'Donnell, Christopher J, Sun, Yan V, Rivas, Manuel A, Montgomery, Stephen B
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 02.06.2022
Témata:	Body Mass Index Genetic Predisposition to Disease Genome-Wide Association Study Humans Multifactorial Inheritance - genetics Obesity - genetics Phenotype Risk Factors rare variants transcriptomics complex disease obesity BMI polygenic risk scores
ISSN:	1537-6605, 1537-6605
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