Poly(lactic acid) nanofibrous scaffolds for tissue engineering

Poly(lactic acid) (PLA) is a synthetic polyester that has shown extensive utility in tissue engineering. Synthesized either by ring opening polymerization or polycondensation, PLA hydrolytically degrades into lactic acid, a metabolic byproduct, making it suitable for medical applications. Specifical...

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Published in:Advanced drug delivery reviews Vol. 107; pp. 206 - 212
Main Authors: Santoro, Marco, Shah, Sarita R., Walker, Jennifer L., Mikos, Antonios G.
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 15.12.2016
Subjects:
Animals
Drug delivery
Humans
Lactic Acid - chemistry
Nanofibers
Nanofibers - chemistry
PLA
Polyesters - chemistry
Scaffolds
Tissue engineering
Tissue Engineering - methods
Tissue Scaffolds - chemistry
PLA
Tissue engineering
ACL
PDLLA
Drug delivery
BMP-2
PDLA
β-TCP
PLLA
PLDLA
HA
PEO
Nanofibers
Scaffolds
TIPS
ISSN:0169-409X, 1872-8294, 1872-8294
Online Access:Get full text
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Summary:Poly(lactic acid) (PLA) is a synthetic polyester that has shown extensive utility in tissue engineering. Synthesized either by ring opening polymerization or polycondensation, PLA hydrolytically degrades into lactic acid, a metabolic byproduct, making it suitable for medical applications. Specifically, PLA nanofibers have widened the possible uses of PLA scaffolds for regenerative medicine and drug delivery applications. The use of nanofibrous scaffolds imparts a host of desirable properties, including high surface area, biomimicry of native extracellular matrix architecture, and tuning of mechanical properties, all of which are important facets of designing scaffolds for a particular organ system. Additionally, nanofibrous PLA scaffolds hold great promise as drug delivery carriers, where fabrication parameters and drug-PLA compatibility greatly affect the drug release kinetics. In this review, we present the latest advances in the use of PLA nanofibrous scaffolds for musculoskeletal, nervous, cardiovascular, and cutaneous tissue engineering and offer perspectives on their future use. [Display omitted]
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ISSN:0169-409X
1872-8294
1872-8294
DOI:10.1016/j.addr.2016.04.019