A novel class of lipophilic quinazoline-based folic acid analogues: cytotoxic agents with a folate-independent locus

Three lipophilic quinazoline-based aminomethyl pyridine compounds, which differ only in the position of the nitrogen in their pyridine ring, are described. CB300179 (2-pyridine), CB300189 (4-pyridine) and CB30865 (3-pyridine) all inhibited isolated mammalian TS with IC50 values of 508, 250 and 156 n...

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Vydané v:	British journal of cancer Ročník 79; číslo 11-12; s. 1692
Hlavní autori:	Skelton, L A, Ormerod, M G, Titley, J, Kimbell, R, Brunton, L A, Jackman, A L
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England 01.04.1999
Predmet:	Animals Antineoplastic Agents - therapeutic use Cell Cycle - drug effects Cell Division - drug effects Cell Survival - drug effects Chemical Precipitation Colony-Forming Units Assay Cytoprotection DNA, Neoplasm - biosynthesis Folic Acid - pharmacology Humans Leukemia L1210 - drug therapy Leukemia L1210 - pathology Lipid Metabolism Mice Quinazolines - therapeutic use Solubility Tumor Cells, Cultured
ISSN:	0007-0920
On-line prístup:	Zistit podrobnosti o prístupe
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