Key for crossing the BBB with nanoparticles: the rational design

Central nervous system diseases are a heavy burden on society and health care systems. Hence, the delivery of drugs to the brain has gained more and more interest. The brain is protected by the blood–brain barrier (BBB), a selective barrier formed by the endothelial cells of the cerebral microvessel...

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Veröffentlicht in:Beilstein journal of nanotechnology Jg. 11; H. 1; S. 866 - 883
Hauptverfasser: Lombardo, Sonia M, Schneider, Marc, Türeli, Akif E, Günday Türeli, Nazende
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Frankfurt am Main Beilstein-Institut zur Föerderung der Chemischen Wissenschaften 04.06.2020
Beilstein-Institut
Schlagworte:
Blood-brain barrier
blood–brain barrier (bbb)
Brain diseases
Central nervous system
Disease
drug delivery
Drug delivery systems
Drugs
Endothelial cells
gold nanoparticles (aunps)
Homeostasis
Ligands
liposomes
nanomedicine
Nanoparticles
Nanoscience
Nanotechnology
Neurological disorders
Neurotoxicity
Physiology
polymeric nanoparticles
Proteins
Review
solid lipid nanoparticles
superparamagnetic iron oxide nanoparticles (spions)
Surface properties
ISSN:2190-4286, 2190-4286
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Abstract Central nervous system diseases are a heavy burden on society and health care systems. Hence, the delivery of drugs to the brain has gained more and more interest. The brain is protected by the blood–brain barrier (BBB), a selective barrier formed by the endothelial cells of the cerebral microvessels, which at the same time acts as a bottleneck for drug delivery by preventing the vast majority of drugs to reach the brain. To overcome this obstacle, drugs can be loaded inside nanoparticles that can carry the drug through the BBB. However, not all particles are able to cross the BBB and a multitude of factors needs to be taken into account when developing a carrier system for this purpose. Depending on the chosen pathway to cross the BBB, nanoparticle material, size and surface properties such as functionalization and charge should be tailored to fit the specific route of BBB crossing.
AbstractList Central nervous system diseases are a heavy burden on society and health care systems. Hence, the delivery of drugs to the brain has gained more and more interest. The brain is protected by the blood–brain barrier (BBB), a selective barrier formed by the endothelial cells of the cerebral microvessels, which at the same time acts as a bottleneck for drug delivery by preventing the vast majority of drugs to reach the brain. To overcome this obstacle, drugs can be loaded inside nanoparticles that can carry the drug through the BBB. However, not all particles are able to cross the BBB and a multitude of factors needs to be taken into account when developing a carrier system for this purpose. Depending on the chosen pathway to cross the BBB, nanoparticle material, size and surface properties such as functionalization and charge should be tailored to fit the specific route of BBB crossing.
Central nervous system diseases are a heavy burden on society and health care systems. Hence, the delivery of drugs to the brain has gained more and more interest. The brain is protected by the blood-brain barrier (BBB), a selective barrier formed by the endothelial cells of the cerebral microvessels, which at the same time acts as a bottleneck for drug delivery by preventing the vast majority of drugs to reach the brain. To overcome this obstacle, drugs can be loaded inside nanoparticles that can carry the drug through the BBB. However, not all particles are able to cross the BBB and a multitude of factors needs to be taken into account when developing a carrier system for this purpose. Depending on the chosen pathway to cross the BBB, nanoparticle material, size and surface properties such as functionalization and charge should be tailored to fit the specific route of BBB crossing.Central nervous system diseases are a heavy burden on society and health care systems. Hence, the delivery of drugs to the brain has gained more and more interest. The brain is protected by the blood-brain barrier (BBB), a selective barrier formed by the endothelial cells of the cerebral microvessels, which at the same time acts as a bottleneck for drug delivery by preventing the vast majority of drugs to reach the brain. To overcome this obstacle, drugs can be loaded inside nanoparticles that can carry the drug through the BBB. However, not all particles are able to cross the BBB and a multitude of factors needs to be taken into account when developing a carrier system for this purpose. Depending on the chosen pathway to cross the BBB, nanoparticle material, size and surface properties such as functionalization and charge should be tailored to fit the specific route of BBB crossing.
Author Lombardo, Sonia M
Günday Türeli, Nazende
Schneider, Marc
Türeli, Akif E
AuthorAffiliation 2 Department of Pharmacy, Biopharmaceutics and Pharmaceutical Technology, Saarland University, Campus C4 1, 66123 Saarbrücken, Germany
1 MyBiotech GmbH; Industriestraße 1B, 66802 Überherrn, Germany
AuthorAffiliation_xml – name: 1 MyBiotech GmbH; Industriestraße 1B, 66802 Überherrn, Germany
– name: 2 Department of Pharmacy, Biopharmaceutics and Pharmaceutical Technology, Saarland University, Campus C4 1, 66123 Saarbrücken, Germany
Author_xml – sequence: 1
  givenname: Sonia M
  orcidid: 0000-0002-8538-5012
  surname: Lombardo
  fullname: Lombardo, Sonia M
– sequence: 2
  givenname: Marc
  orcidid: 0000-0002-9260-7357
  surname: Schneider
  fullname: Schneider, Marc
– sequence: 3
  givenname: Akif E
  surname: Türeli
  fullname: Türeli, Akif E
– sequence: 4
  givenname: Nazende
  orcidid: 0000-0002-6310-4785
  surname: Günday Türeli
  fullname: Günday Türeli, Nazende
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Snippet Central nervous system diseases are a heavy burden on society and health care systems. Hence, the delivery of drugs to the brain has gained more and more...
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SubjectTerms Blood-brain barrier
blood–brain barrier (bbb)
Brain diseases
Central nervous system
Disease
drug delivery
Drug delivery systems
Drugs
Endothelial cells
gold nanoparticles (aunps)
Homeostasis
Ligands
liposomes
nanomedicine
Nanoparticles
Nanoscience
Nanotechnology
Neurological disorders
Neurotoxicity
Physiology
polymeric nanoparticles
Proteins
Review
solid lipid nanoparticles
superparamagnetic iron oxide nanoparticles (spions)
Surface properties
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Title Key for crossing the BBB with nanoparticles: the rational design
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Volume 11
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