Family Clustering of Autoimmune Vitiligo Results Principally from Polygenic Inheritance of Common Risk Alleles

Vitiligo is an autoimmune disease that results in patches of depigmented skin and hair. Previous genome-wide association studies (GWASs) of vitiligo have identified 50 susceptibility loci. Variants at the associated loci are generally common and have individually small effects on risk. Most vitiligo...

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Vydáno v:	American journal of human genetics Ročník 105; číslo 2; s. 364
Hlavní autoři:	Roberts, Genevieve H L, Paul, Subrata, Yorgov, Daniel, Santorico, Stephanie A, Spritz, Richard A
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.08.2019
Témata:	Alleles Autoimmune Diseases - genetics Autoimmune Diseases - pathology Case-Control Studies Family Female Genes - genetics Genetic Predisposition to Disease Genome-Wide Association Study Genotype Humans Male Multifactorial Inheritance Polymorphism, Single Nucleotide Risk Factors Vitiligo - genetics Vitiligo - pathology genetic architecture vitiligo genetic risk score family clustering autoimmunity polygenic inheritance
ISSN:	1537-6605, 1537-6605
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