Deciphering the quantitative relationship between NRF2 and SRXN1 through semi-mechanistic computational modeling

Nuclear factor erythroid 2-related factor 2 (NRF2) plays a vital role in the regulation of various antioxidant response element (ARE) genes, which control physiological processes such as oxidative stress, autophagy, proliferation and apoptosis to maintain cellular homeostasis. It is not understood i...

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Vydáno v:	Toxicology (Amsterdam) Ročník 519; s. 154284
Hlavní autoři:	Sharma, Raju Prasad, Loonstra-Wolters, Liesanne, ter Braak, Bas, Niemeijer, Marije, White, Andrew, van de Water, Bob, Middleton, Alistair M., Beltman, Joost B.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Ireland Elsevier B.V 01.01.2026
Témata:	Chemical exposure Computer Simulation Emergency Hep G2 Cells Hepatotoxicity Humans Models, Biological NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Nonlinear mixed effect modeling NRF2 Oxidoreductases Acting on Sulfur Group Donors - genetics Oxidoreductases Acting on Sulfur Group Donors - metabolism Repeated exposure SRXN1 Repeated exposure Chemical exposure NRF2 SRXN1 Hepatotoxicity Nonlinear mixed effect modeling
ISSN:	0300-483X, 1879-3185, 1879-3185
On-line přístup:	Získat plný text
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