Evaluation of the effectiveness and safety of oral vancomycin versus placebo in the prevention of recurrence of Clostridioides difficile infection in patients under systemic antibiotic therapy: a phase III, randomised, double-blind clinical trial

infection (CDI) is the most prevalent cause of nosocomial bacterial diarrhoea and it is strongly associated with antibiotic use. The recurrence of CDI is a growing medical problem. Data from real-life studies and one open label randomised clinical trial (RCT) suggest that secondary prophylaxis with...

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Bibliographic Details
Published in:	BMJ open Vol. 13; no. 9; p. e072121
Main Authors:	San-Juan, Rafael, Origuen, Julia, Campion, Karen, Fernández-Ruiz, Mario, Diaz-Pollan, Beatriz, Callejas-Diaz, Alejandro, Candela, Giancarlo, Orellana, Maria Angeles, Lora, David, Llorente Muñoz, Irene, Garcia, Maria Teresa, Martinez-Uña, Maite, Ferrari, Jose Miguel, Aguado, Jose M
Format:	Journal Article
Language:	English
Published:	England BMJ Publishing Group LTD 13.09.2023 BMJ Publishing Group
Series:	Protocol
Subjects:	Adult Anti-Bacterial Agents - therapeutic use Antibiotics Clinical trials Clostridium Infections - prevention & control Diarrhea Disease prevention Double-blind studies Drug dosages Hospitals Hospitals, University Humans Infections Infectious Diseases Informed consent Medical ethics Microbiota Secondary Prevention Structured Query Language-SQL Vancomycin - therapeutic use United States > US gastrointestinal infections epidemiology infection control
ISSN:	2044-6055, 2044-6055
Online Access:	Get full text
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