Estimating the Effectiveness of DPYD Genotyping in Italian Individuals Suffering from Cancer Based on the Cost of Chemotherapy-Induced Toxicity

Fluoropyrimidines (FLs) have been widely used for more than 60 years against a range of solid tumors and still remains the cornerstone for the treatment of colorectal, gastric, and breast cancer. Here, we performed an economic analysis to estimate the cost of DPYD-guided toxicity management and the...

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Bibliographic Details
Published in:	American journal of human genetics Vol. 104; no. 6; p. 1158
Main Authors:	Fragoulakis, Vasileios, Roncato, Rossana, Fratte, Chiara Dalle, Ecca, Fabrizio, Bartsakoulia, Marina, Innocenti, Federico, Toffoli, Giuseppe, Cecchin, Erika, Patrinos, George P, Mitropoulou, Christina
Format:	Journal Article
Language:	English
Published:	United States 06.06.2019
Subjects:	Antineoplastic Combined Chemotherapy Protocols - adverse effects Cost-Benefit Analysis Dihydrouracil Dehydrogenase (NADP) - genetics Dihydrouracil Dehydrogenase (NADP) - metabolism Drug-Related Side Effects and Adverse Reactions - economics Drug-Related Side Effects and Adverse Reactions - etiology Drug-Related Side Effects and Adverse Reactions - pathology Female Follow-Up Studies Genetic Testing - methods Humans Male Middle Aged Neoplasms - drug therapy Neoplasms - economics Neoplasms - genetics Neoplasms - pathology Polymorphism, Single Nucleotide Prognosis Pyrimidines - adverse effects Retrospective Studies Survival Rate antimetabolite fluoropyrimidines cost-effectiveness economic evaluation DPYD genotyping FL
ISSN:	1537-6605, 1537-6605
Online Access:	Get more information
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