Neuroinflammation in glaucoma: A new opportunity
Mounting evidence suggests neuroinflammation is a key process in glaucoma, yet the precise roles are not known. Understanding these complex processes, which may also be a key in other common neurodegenerations such as Alzheimer's disease, will lead to targeted therapeutics for a disease that af...
Gespeichert in:
| Veröffentlicht in: | Experimental eye research Jg. 157; S. 20 - 27 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
England
Elsevier Ltd
01.04.2017
|
| Schlagworte: | |
| ISSN: | 0014-4835, 1096-0007, 1096-0007 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | Mounting evidence suggests neuroinflammation is a key process in glaucoma, yet the precise roles are not known. Understanding these complex processes, which may also be a key in other common neurodegenerations such as Alzheimer's disease, will lead to targeted therapeutics for a disease that affects as many as 80 million people worldwide. Here, we define neuroinflammation as any immune-relevant response by a variety of cell types including astrocytes, microglia, and peripherally derived cells occurring in the optic nerve head and/or retina. In this review article, we first discuss clinical evidence for neuroinflammation in glaucoma and define neuroinflammation in glaucoma. We then review the inflammatory pathways that have been associated with glaucoma. Finally, we set out key research directions that we believe will greatly advance our understanding of the role of neuroinflammation in glaucoma. This review arose from a discussion of neuroinflammation in glaucoma at the 2015 meeting of The Lasker/IRRF Initiative for Innovation in Vision Science. This manuscript sets out to summarize one of these sessions; “Inflammation and Glaucomatous Neurodegeneration”, as well as to review the current state of the literature surrounding neuroinflammation in glaucoma.
•We describe the clinical relevance of inflammation in glaucoma.•We define the sites of neuroinflammation in glaucoma.•We discuss the roles of different cells and pathways in glaucoma.•We discuss suggested 5 year goals as set about by the participants of the 2015 Lasker/IRRF Initiative session “Inflammation and Glaucomatous Neurodegeneration”. |
|---|---|
| AbstractList | Mounting evidence suggests neuroinflammation is a key process in glaucoma, yet the precise roles are not known. Understanding these complex processes, which may also be a key in other common neurodegenerations such as Alzheimer’s disease, will lead to targeted therapeutics for a disease that affects as many as 80 million people worldwide. Here, we define neuroinflammation as any immune-relevant response by a variety of cell types including astrocytes, microglia, and peripherally derived cells occurring in the optic nerve head and/or retina. In this review article, we first discuss clinical evidence for neuroinflammation in glaucoma and define neuroinflammation in glaucoma. We then review the inflammatory pathways that have been associated with glaucoma. Finally, we set out key research directions that we believe will greatly advance our understanding of the role of neuroinflammation in glaucoma. This review arose from a discussion of neuroinflammation in glaucoma at the 2015 meeting of the The Lasker/IRRF Initiative for Innovation in Vision Science. This manuscript sets out to summarize one of these sessions; “Inflammation and Glaucomatous Neurodegeneration”, as well as to review the current state of the literature surrounding neuroinflammation in glaucoma. Mounting evidence suggests neuroinflammation is a key process in glaucoma, yet the precise roles are not known. Understanding these complex processes, which may also be a key in other common neurodegenerations such as Alzheimer's disease, will lead to targeted therapeutics for a disease that affects as many as 80 million people worldwide. Here, we define neuroinflammation as any immune-relevant response by a variety of cell types including astrocytes, microglia, and peripherally derived cells occurring in the optic nerve head and/or retina. In this review article, we first discuss clinical evidence for neuroinflammation in glaucoma and define neuroinflammation in glaucoma. We then review the inflammatory pathways that have been associated with glaucoma. Finally, we set out key research directions that we believe will greatly advance our understanding of the role of neuroinflammation in glaucoma. This review arose from a discussion of neuroinflammation in glaucoma at the 2015 meeting of The Lasker/IRRF Initiative for Innovation in Vision Science. This manuscript sets out to summarize one of these sessions; "Inflammation and Glaucomatous Neurodegeneration", as well as to review the current state of the literature surrounding neuroinflammation in glaucoma. Mounting evidence suggests neuroinflammation is a key process in glaucoma, yet the precise roles are not known. Understanding these complex processes, which may also be a key in other common neurodegenerations such as Alzheimer's disease, will lead to targeted therapeutics for a disease that affects as many as 80 million people worldwide. Here, we define neuroinflammation as any immune-relevant response by a variety of cell types including astrocytes, microglia, and peripherally derived cells occurring in the optic nerve head and/or retina. In this review article, we first discuss clinical evidence for neuroinflammation in glaucoma and define neuroinflammation in glaucoma. We then review the inflammatory pathways that have been associated with glaucoma. Finally, we set out key research directions that we believe will greatly advance our understanding of the role of neuroinflammation in glaucoma. This review arose from a discussion of neuroinflammation in glaucoma at the 2015 meeting of The Lasker/IRRF Initiative for Innovation in Vision Science. This manuscript sets out to summarize one of these sessions; "Inflammation and Glaucomatous Neurodegeneration", as well as to review the current state of the literature surrounding neuroinflammation in glaucoma.Mounting evidence suggests neuroinflammation is a key process in glaucoma, yet the precise roles are not known. Understanding these complex processes, which may also be a key in other common neurodegenerations such as Alzheimer's disease, will lead to targeted therapeutics for a disease that affects as many as 80 million people worldwide. Here, we define neuroinflammation as any immune-relevant response by a variety of cell types including astrocytes, microglia, and peripherally derived cells occurring in the optic nerve head and/or retina. In this review article, we first discuss clinical evidence for neuroinflammation in glaucoma and define neuroinflammation in glaucoma. We then review the inflammatory pathways that have been associated with glaucoma. Finally, we set out key research directions that we believe will greatly advance our understanding of the role of neuroinflammation in glaucoma. This review arose from a discussion of neuroinflammation in glaucoma at the 2015 meeting of The Lasker/IRRF Initiative for Innovation in Vision Science. This manuscript sets out to summarize one of these sessions; "Inflammation and Glaucomatous Neurodegeneration", as well as to review the current state of the literature surrounding neuroinflammation in glaucoma. Mounting evidence suggests neuroinflammation is a key process in glaucoma, yet the precise roles are not known. Understanding these complex processes, which may also be a key in other common neurodegenerations such as Alzheimer's disease, will lead to targeted therapeutics for a disease that affects as many as 80 million people worldwide. Here, we define neuroinflammation as any immune-relevant response by a variety of cell types including astrocytes, microglia, and peripherally derived cells occurring in the optic nerve head and/or retina. In this review article, we first discuss clinical evidence for neuroinflammation in glaucoma and define neuroinflammation in glaucoma. We then review the inflammatory pathways that have been associated with glaucoma. Finally, we set out key research directions that we believe will greatly advance our understanding of the role of neuroinflammation in glaucoma. This review arose from a discussion of neuroinflammation in glaucoma at the 2015 meeting of The Lasker/IRRF Initiative for Innovation in Vision Science. This manuscript sets out to summarize one of these sessions; “Inflammation and Glaucomatous Neurodegeneration”, as well as to review the current state of the literature surrounding neuroinflammation in glaucoma. •We describe the clinical relevance of inflammation in glaucoma.•We define the sites of neuroinflammation in glaucoma.•We discuss the roles of different cells and pathways in glaucoma.•We discuss suggested 5 year goals as set about by the participants of the 2015 Lasker/IRRF Initiative session “Inflammation and Glaucomatous Neurodegeneration”. |
| Author | Simon, John Williams, Pete A. Marsh-Armstrong, Nick Di Polo, Adriana Trounce, Ian Danias, John Howell, Gareth R. Kuehn, Markus H. Przedborski, Serge Raff, Martin Bosco, Alejandra |
| AuthorAffiliation | 4 Graduate Program of Genetics, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA, USA 2 The Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD, USA 3 Hugo W. Moser Research Institute, Kennedy Krieger Institute, Baltimore, MD, USA 1 The Jackson Laboratory, Bar Harbor, ME, USA |
| AuthorAffiliation_xml | – name: 4 Graduate Program of Genetics, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA, USA – name: 2 The Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD, USA – name: 1 The Jackson Laboratory, Bar Harbor, ME, USA – name: 3 Hugo W. Moser Research Institute, Kennedy Krieger Institute, Baltimore, MD, USA |
| Author_xml | – sequence: 1 givenname: Pete A. orcidid: 0000-0001-6194-8397 surname: Williams fullname: Williams, Pete A. organization: The Jackson Laboratory, Bar Harbor, ME, USA – sequence: 2 givenname: Nick surname: Marsh-Armstrong fullname: Marsh-Armstrong, Nick organization: The Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD, USA – sequence: 3 givenname: Gareth R. surname: Howell fullname: Howell, Gareth R. email: gareth.howell@jax.org organization: The Jackson Laboratory, Bar Harbor, ME, USA – sequence: 4 givenname: Alejandra surname: Bosco fullname: Bosco, Alejandra organization: University of Utah, School of Medicine, Salt Lake City, UT, USA – sequence: 5 givenname: John surname: Danias fullname: Danias, John organization: Department of Ophthalmology, SUNY Downstate, NY, USA – sequence: 6 givenname: John surname: Simon fullname: Simon, John organization: The Jackson Laboratory, Bar Harbor, ME, USA – sequence: 7 givenname: Adriana surname: Di Polo fullname: Di Polo, Adriana organization: Department of Neuroscience and Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Université de Montréal, Montréal, Québec, Canada – sequence: 8 givenname: Markus H. surname: Kuehn fullname: Kuehn, Markus H. organization: Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, IA, USA – sequence: 9 givenname: Serge surname: Przedborski fullname: Przedborski, Serge organization: Departments of Pathology & Cell Biology, Columbia University Medical Center, NY, USA – sequence: 10 givenname: Martin surname: Raff fullname: Raff, Martin organization: MRC Laboratory for Molecular Cell Biology, University College London, London, UK – sequence: 11 givenname: Ian surname: Trounce fullname: Trounce, Ian organization: Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, East Melbourne, Victoria, Australia |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28242160$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9UctKxDAUDaLo-PgBF9Klm9abTNpkRAQRXyC60XXIpLeaoU3GpPXx92YcFXXh6sK55wHnbJJV5x0SskuhoECrg1mBrxgKBlQUwAqgfIWMKEyqHADEKhlBgnIux-UG2YxxltAxF3ydbDDJOKMVjAjc4BC8dU2ru0731rvMuuyh1YPxnT7MTjKHL5mfz33oB2f7t22y1ug24s7n3SL352d3p5f59e3F1enJdW54WfY5oxqRUdnQGlCzSsupgIpVWCIKg1NDQfB6wsf1RBrOkEPNGiN5yae0MaUYb5Hjpe98mHZYG3R90K2aB9vp8Ka8tur3x9lH9eCfVcknopQsGex_GgT_NGDsVWejwbbVDv0QFZWCSclTEYm69zPrO-SrpkSQS4IJPsaAjTK2_2grRdtWUVCLRdRMLRZRi0UUMJXqT1L2R_rl_q_oaCnC1PCzTd9oLDqDtQ1oelV7-5_8HcblpVI |
| CitedBy_id | crossref_primary_10_1186_s13024_018_0303_3 crossref_primary_10_3389_fimmu_2020_566279 crossref_primary_10_3390_ijms242115516 crossref_primary_10_3390_ijms231710179 crossref_primary_10_1186_s12886_019_1273_0 crossref_primary_10_1016_j_bcp_2020_114199 crossref_primary_10_1371_journal_pone_0323513 crossref_primary_10_3389_fnut_2021_753955 crossref_primary_10_1007_s13273_024_00469_z crossref_primary_10_1016_j_exer_2020_108315 crossref_primary_10_1016_j_ajo_2023_05_023 crossref_primary_10_1016_j_pneurobio_2018_09_007 crossref_primary_10_3390_ijms242015359 crossref_primary_10_4103_1673_5374_385310 crossref_primary_10_3389_fimmu_2020_585918 crossref_primary_10_3389_fnagi_2017_00214 crossref_primary_10_1016_j_preteyeres_2023_101169 crossref_primary_10_1007_s00210_025_03926_1 crossref_primary_10_1016_j_exer_2025_110246 crossref_primary_10_1002_jbt_70121 crossref_primary_10_21303_2504_5679_2020_001476 crossref_primary_10_1186_s12974_021_02236_6 crossref_primary_10_1016_j_micpath_2021_105253 crossref_primary_10_3389_fmed_2021_643402 crossref_primary_10_1016_j_neurobiolaging_2023_07_009 crossref_primary_10_3390_brainsci14010041 crossref_primary_10_1007_s12035_024_04563_0 crossref_primary_10_2147_JIR_S329084 crossref_primary_10_1016_j_preteyeres_2020_100916 crossref_primary_10_1007_s12264_025_01417_0 crossref_primary_10_1155_2020_5384602 crossref_primary_10_3389_fcell_2023_1173235 crossref_primary_10_1007_s13167_023_00336_2 crossref_primary_10_1016_j_addr_2023_115006 crossref_primary_10_7554_eLife_42049 crossref_primary_10_1016_j_prostaglandins_2024_106815 crossref_primary_10_3390_bioengineering11111063 crossref_primary_10_1007_s11306_020_1650_y crossref_primary_10_1089_jop_2017_0041 crossref_primary_10_3389_fmed_2021_750342 crossref_primary_10_1038_s41598_019_52500_2 crossref_primary_10_1016_j_nbd_2021_105258 crossref_primary_10_1016_j_preteyeres_2020_100840 crossref_primary_10_1167_iovs_63_11_9 crossref_primary_10_1016_j_biopha_2023_115052 crossref_primary_10_3390_jcm9123838 crossref_primary_10_1167_iovs_65_2_36 crossref_primary_10_1186_s13024_023_00658_9 crossref_primary_10_1155_2022_8063651 crossref_primary_10_1111_cns_13610 crossref_primary_10_1146_annurev_vision_091517_034425 crossref_primary_10_1016_j_exer_2021_108806 crossref_primary_10_3389_fncel_2023_1106547 crossref_primary_10_3390_biomedicines9050473 crossref_primary_10_1007_s12035_020_01910_9 crossref_primary_10_1016_j_oftale_2018_01_001 crossref_primary_10_1016_j_exer_2018_02_002 crossref_primary_10_3390_nu14040779 crossref_primary_10_3389_fbioe_2025_1574231 crossref_primary_10_1016_j_preteyeres_2021_100998 crossref_primary_10_1080_10717544_2024_2379369 crossref_primary_10_12998_wjcc_v9_i3_697 crossref_primary_10_1083_jcb_201912047 crossref_primary_10_3389_fimmu_2022_1094132 crossref_primary_10_1089_jop_2024_0046 crossref_primary_10_1016_j_intimp_2020_106608 crossref_primary_10_1038_s41419_023_05617_2 crossref_primary_10_1016_j_exer_2023_109678 crossref_primary_10_3389_fimmu_2022_857812 crossref_primary_10_3389_fcell_2022_903436 crossref_primary_10_3390_ijms25158193 crossref_primary_10_1523_JNEUROSCI_1854_18_2018 crossref_primary_10_3389_fphar_2020_01038 crossref_primary_10_1080_21691401_2019_1671430 crossref_primary_10_3390_ijms22073798 crossref_primary_10_3389_fmed_2021_733080 crossref_primary_10_3389_fnins_2021_610788 crossref_primary_10_3389_fimmu_2021_616421 crossref_primary_10_1007_s00417_018_4081_y crossref_primary_10_3389_fphar_2021_601404 crossref_primary_10_3389_fnins_2017_00478 crossref_primary_10_1002_glia_24600 crossref_primary_10_1002_bies_201800046 crossref_primary_10_1073_pnas_2014213117 crossref_primary_10_3390_jcm10173938 crossref_primary_10_1186_s13024_021_00466_z crossref_primary_10_1523_JNEUROSCI_0844_21_2021 crossref_primary_10_3389_fneur_2020_612422 crossref_primary_10_1186_s13041_020_00603_7 crossref_primary_10_3390_jcm9103172 crossref_primary_10_1016_j_ymthe_2018_08_017 crossref_primary_10_1038_s41419_020_03337_5 crossref_primary_10_3390_cells10020295 crossref_primary_10_1016_j_prp_2024_155552 crossref_primary_10_1186_s43094_025_00798_3 crossref_primary_10_1186_s13024_022_00524_0 crossref_primary_10_4103_1673_5374_330594 crossref_primary_10_1093_rb_rbae133 crossref_primary_10_3390_ijms22157994 crossref_primary_10_1038_s41385_020_0282_x crossref_primary_10_1167_iovs_18_26129 crossref_primary_10_1167_iovs_64_10_4 crossref_primary_10_1242_dev_199694 crossref_primary_10_3390_ijms222011077 crossref_primary_10_1167_iovs_19_27545 crossref_primary_10_1016_j_exer_2021_108520 crossref_primary_10_3390_molecules24020252 crossref_primary_10_1007_s13167_021_00260_3 crossref_primary_10_1016_j_immuni_2022_07_014 crossref_primary_10_3390_ijms24021166 crossref_primary_10_1016_j_intimp_2023_110952 crossref_primary_10_3389_fnagi_2024_1396443 crossref_primary_10_2147_OPTH_S364739 crossref_primary_10_3390_brainsci11050663 crossref_primary_10_3389_fimmu_2020_573955 crossref_primary_10_1007_s10792_025_03620_4 crossref_primary_10_1136_bjophthalmol_2021_319232 crossref_primary_10_1097_IJG_0000000000001593 crossref_primary_10_1111_aos_15161 crossref_primary_10_1167_iovs_18_25447 crossref_primary_10_1097_IJG_0000000000002448 crossref_primary_10_1371_journal_pone_0196529 crossref_primary_10_1038_s41598_020_61848_9 crossref_primary_10_1167_iovs_19_27135 crossref_primary_10_3390_cells12121558 crossref_primary_10_3390_app10207071 crossref_primary_10_1371_journal_pone_0190039 crossref_primary_10_1038_s41598_020_59941_0 crossref_primary_10_1002_jbt_23631 crossref_primary_10_1038_s41598_022_05273_0 crossref_primary_10_1016_j_ejphar_2023_176231 crossref_primary_10_1007_s00417_019_04239_9 crossref_primary_10_3390_cells10061372 crossref_primary_10_3892_mmr_2024_13207 crossref_primary_10_1016_j_drudis_2023_103757 crossref_primary_10_1007_s00011_017_1085_8 crossref_primary_10_1016_j_biomaterials_2021_120682 crossref_primary_10_1038_s44341_025_00022_6 crossref_primary_10_3389_fnins_2018_00834 crossref_primary_10_1016_j_oftal_2017_11_002 crossref_primary_10_1155_2019_9274585 crossref_primary_10_1016_j_ecoenv_2022_114231 crossref_primary_10_1016_j_ajo_2019_04_035 crossref_primary_10_1007_s12031_017_1020_z crossref_primary_10_1186_s40478_025_02066_0 crossref_primary_10_3390_ijms23158068 crossref_primary_10_1177_11206721231219147 crossref_primary_10_4103_1673_5374_320980 crossref_primary_10_3389_fphar_2021_729249 crossref_primary_10_1038_s41598_020_74589_6 crossref_primary_10_1016_j_heliyon_2024_e28806 crossref_primary_10_1038_s41598_018_22737_4 crossref_primary_10_1167_iovs_65_2_7 crossref_primary_10_1167_iovs_64_7_24 crossref_primary_10_1007_s12035_019_01863_8 crossref_primary_10_1016_j_exer_2020_107996 crossref_primary_10_3389_fphar_2021_797110 crossref_primary_10_1038_s41434_021_00281_7 crossref_primary_10_1186_s12974_020_01930_1 crossref_primary_10_1016_j_arr_2022_101572 crossref_primary_10_1136_bjophthalmol_2020_316169 crossref_primary_10_3390_pharmaceutics15051370 crossref_primary_10_4103_1673_5374_310670 crossref_primary_10_1038_s41598_020_65116_8 crossref_primary_10_3390_biom11081239 crossref_primary_10_3390_biom12020281 crossref_primary_10_1016_j_exer_2017_02_013 crossref_primary_10_1080_17469899_2021_1990758 crossref_primary_10_1038_s41421_023_00588_2 crossref_primary_10_1177_11206721211037133 crossref_primary_10_3389_fneur_2021_624983 crossref_primary_10_1016_j_preteyeres_2025_101379 crossref_primary_10_1111_aos_15786 crossref_primary_10_1016_j_prostaglandins_2021_106578 crossref_primary_10_1002_dvdy_1 crossref_primary_10_1016_j_trsl_2021_05_005 crossref_primary_10_3390_cells13121046 |
| Cites_doi | 10.3928/15428877-20070301-06 10.1371/journal.pone.0099719 10.1016/j.cell.2007.10.036 10.1371/journal.pone.0122184 10.3109/00207454.2013.878340 10.1016/j.survophthal.2012.08.010 10.1016/j.survophthal.2012.04.006 10.1523/JNEUROSCI.2801-06.2006 10.1016/j.brainres.2005.06.053 10.1684/ecn.2013.0334 10.1016/j.exer.2009.02.005 10.1186/s40478-015-0234-y 10.1016/j.ophtha.2008.08.024 10.1038/sj.cdd.4401189 10.1038/sj.eye.6702078 10.1007/978-1-4419-5635-4_7 10.1097/IJG.0000000000000083 10.1016/j.neulet.2013.10.012 10.1002/glia.22507 10.1097/00055735-200404000-00003 10.1186/s12974-014-0194-3 10.1111/j.1749-6632.2012.06686.x 10.1016/bs.pmbts.2015.04.008 10.1371/journal.pone.0104416 10.1097/APO.0b013e31824a65f8 10.1167/iovs.11-8152 10.1101/cshperspect.a017269 10.1097/ICU.0b013e3282f3e6bc 10.1016/S0002-9394(00)00862-X 10.1007/s12177-009-9026-6 10.1016/1043-4666(92)90028-P 10.1016/S0079-6123(08)01128-X 10.1002/glia.21242 10.1016/S0079-6123(08)01122-9 10.1167/iovs.06-1282 10.1007/s00417-014-2588-4 10.1146/annurev.neuro.051508.135728 10.1001/archopht.117.8.1050 10.3389/fncel.2014.00362 10.1167/iovs.10-5407 10.1097/IJG.0b013e31802d045a 10.1167/iovs.10-5289 10.1002/cne.22516 10.1007/s00417-010-1441-7 10.1186/1742-2094-10-76 10.1097/IJG.0000000000000115 10.3109/02713683.2011.566409 10.1016/j.ajo.2012.03.050 10.1167/iovs.05-0830 10.4103/0974-620X.77655 10.1073/pnas.1506486112 10.1111/j.1755-3768.1983.tb01412.x 10.1016/S0002-9394(01)01009-1 10.1111/j.1749-6632.2010.05760.x 10.1016/j.preteyeres.2009.06.001 10.1016/j.exer.2015.08.014 10.1172/JCI44646 10.1167/iovs.12-10109 10.1371/journal.pone.0040065 10.1089/jop.2014.0163 10.1186/1755-8794-2-24 10.1073/pnas.1013965108 10.1007/s00417-010-1608-2 10.1167/iovs.07-1337 10.1167/iovs.15-16739 10.1016/j.exer.2010.08.009 10.1016/j.preteyeres.2012.04.004 10.1001/archopht.124.4.520 10.1167/iovs.13-12941 10.1002/jnr.1104 10.1371/journal.pone.0067094 10.1371/journal.pone.0071808 10.3109/02713683.2013.836541 10.2741/s433 10.1167/iovs.14-14429 10.1007/s00441-013-1666-y 10.1002/1098-1136(200010)32:1<42::AID-GLIA40>3.0.CO;2-3 10.4103/0301-4738.98700 10.1167/iovs.07-1575 10.1016/j.exer.2017.02.013 10.1523/JNEUROSCI.1273-15.2015 10.1016/j.coi.2014.05.005 10.1006/exer.1998.0577 10.1016/j.matbio.2014.03.007 10.1167/iovs.10-5317 10.1016/j.nbd.2014.07.016 10.1111/j.1442-9071.2011.02595.x 10.3760/cma.j.issn.0366-6999.20123565 10.1038/sj.eye.6700227 10.1016/0039-6257(89)90010-6 10.1016/0006-8993(89)90078-4 10.3892/mmr.2014.2772 10.1172/JCI61135 10.1371/journal.pone.0043602 |
| ContentType | Journal Article |
| Contributor | Simon, John Di Polo, Adriana Kuehn, Markus H Trounce, Ian Danias, John Przedborski, Serge Raff, Martin Bosco, Alejandra |
| Contributor_xml | – sequence: 1 givenname: Alejandra surname: Bosco fullname: Bosco, Alejandra organization: University of Utah, School of Medicine, Salt Lake City, UT, USA – sequence: 2 givenname: John surname: Danias fullname: Danias, John organization: Department of Ophthalmology, SUNY Downstate, NY, USA – sequence: 3 givenname: John surname: Simon fullname: Simon, John organization: The Jackson Laboratory, Bar Harbor, ME, USA – sequence: 4 givenname: Adriana surname: Di Polo fullname: Di Polo, Adriana organization: Department of Neuroscience and Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Université de Montréal, Montréal, Québec, Canada – sequence: 5 givenname: Markus H surname: Kuehn fullname: Kuehn, Markus H organization: Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, IA, USA – sequence: 6 givenname: Serge surname: Przedborski fullname: Przedborski, Serge organization: Departments of Pathology & Cell Biology, Columbia University Medical Center, NY, USA – sequence: 7 givenname: Martin surname: Raff fullname: Raff, Martin organization: MRC Laboratory for Molecular Cell Biology, University College London, London, UK – sequence: 8 givenname: Ian surname: Trounce fullname: Trounce, Ian organization: Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, East Melbourne, Victoria, Australia |
| Copyright | 2017 Elsevier Ltd Copyright © 2017 Elsevier Ltd. All rights reserved. |
| Copyright_xml | – notice: 2017 Elsevier Ltd – notice: Copyright © 2017 Elsevier Ltd. All rights reserved. |
| CorporateAuthor | The Lasker/IRRF Initiative on Astrocytes and Glaucomatous Neurodegeneration Participants Lasker/IRRF Initiative on Astrocytes and Glaucomatous Neurodegeneration Participants |
| CorporateAuthor_xml | – name: The Lasker/IRRF Initiative on Astrocytes and Glaucomatous Neurodegeneration Participants – name: Lasker/IRRF Initiative on Astrocytes and Glaucomatous Neurodegeneration Participants |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM |
| DOI | 10.1016/j.exer.2017.02.014 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Anatomy & Physiology |
| EISSN | 1096-0007 |
| EndPage | 27 |
| ExternalDocumentID | PMC5497582 28242160 10_1016_j_exer_2017_02_014 S0014483517301446 |
| Genre | Journal Article Review |
| GrantInformation_xml | – fundername: NEI NIH HHS grantid: R01 EY021525 |
| GroupedDBID | --- --K --M .55 .GJ .~1 0R~ 1B1 1RT 1~. 1~5 29G 3O- 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 8P~ 9JM AAAJQ AACTN AADPK AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AARKO AAXLA AAXUO ABBQC ABCQJ ABFNM ABJNI ABLJU ABLVK ABMAC ABMZM ABXDB ABYKQ ACDAQ ACGFS ACNCT ACRLP ADBBV ADEZE ADFGL ADMUD AEBSH AEKER AENEX AFFNX AFKWA AFTJW AFXIZ AGEKW AGHFR AGUBO AGWIK AGYEJ AHHHB AHPSJ AIEXJ AIKHN AITUG AJBFU AJOXV AJRQY ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV C45 CAG CJTIS COF CS3 DM4 DU5 EBS EFBJH EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HEA HMK HMO HMQ HVGLF HZ~ IHE J1W KOM L7B LCYCR LG5 LUGTX LZ2 M29 M2U M41 MO0 MOBAO MVM N9A O-L O9- OAUVE OVD OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SAE SCC SDF SDG SDP SES SEW SNS SPCBC SSH SSI SSN SSZ T5K TEORI WUQ X7M XPP ZA5 ZGI ZMT ZU3 ~G- 9DU AATTM AAXKI AAYWO AAYXX ABWVN ACIEU ACLOT ACRPL ACVFH ADCNI ADNMO AEIPS AEUPX AFJKZ AFPUW AGQPQ AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP CITATION EFKBS ~HD AGCQF AGRNS CGR CUY CVF ECM EIF NPM 7X8 5PM |
| ID | FETCH-LOGICAL-c455t-21aee218f1d0ea26a8b70626e5ee7cebc1074d943d98c42e40d2fc8454b1fc573 |
| ISICitedReferencesCount | 196 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000401305600004&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0014-4835 1096-0007 |
| IngestDate | Tue Sep 30 16:52:54 EDT 2025 Sun Sep 28 02:18:32 EDT 2025 Mon Jul 21 05:59:51 EDT 2025 Tue Nov 18 21:50:08 EST 2025 Sat Nov 29 05:31:31 EST 2025 Fri Feb 23 02:29:42 EST 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | Glaucoma Monocyte Neurodegeneration Lasker Inflammation Astrocyte Microglia |
| Language | English |
| License | Copyright © 2017 Elsevier Ltd. All rights reserved. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c455t-21aee218f1d0ea26a8b70626e5ee7cebc1074d943d98c42e40d2fc8454b1fc573 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 Authors contributed equally The following participated in the session “Inflammation and Glaucomatous Neurodegeneration”: Discussion leaders: Nick Marsh-Armstrong, Gareth R Howell. Scribe: Pete A Williams. Discussion Participants: Alejandra Bosco, John Danias, Adriana Di Polo, Simon John, Markus H. Kuehn, Serge Przedborski, Martin Raff, Ian Trounce |
| ORCID | 0000-0001-6194-8397 |
| OpenAccessLink | http://doi.org/10.1016/j.exer.2017.02.014 |
| PMID | 28242160 |
| PQID | 1872884242 |
| PQPubID | 23479 |
| PageCount | 8 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_5497582 proquest_miscellaneous_1872884242 pubmed_primary_28242160 crossref_citationtrail_10_1016_j_exer_2017_02_014 crossref_primary_10_1016_j_exer_2017_02_014 elsevier_sciencedirect_doi_10_1016_j_exer_2017_02_014 |
| PublicationCentury | 2000 |
| PublicationDate | 2017-04-01 |
| PublicationDateYYYYMMDD | 2017-04-01 |
| PublicationDate_xml | – month: 04 year: 2017 text: 2017-04-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | Experimental eye research |
| PublicationTitleAlternate | Exp Eye Res |
| PublicationYear | 2017 |
| Publisher | Elsevier Ltd |
| Publisher_xml | – name: Elsevier Ltd |
| References | da Fonseca, Matias, Garcia, Amaral, Geraldo, Freitas (bib17) 2014; 8 Levkovitch-Verbin, Waserzoog, Vander, Makarovsky, Piven (bib49) 2014; 252 Tektas, Heinz, Heiligenhaus, Hammer, Luetjen-Drecoll (bib82) 2011; 36 Mac Nair, Fernandes, Schlamp, Libby, Nickells (bib53) 2014; 11 Vohra, Tsai, Kolko (bib87) 2013; 58 Tezel (bib83) 2008; 173 Wallace, Pokrovskaya, O'Brien (bib91) 2015; 31 Fan, Li, Wang, Mo, Kaplan, Cooper (bib25) 2010; 1 Wax, Tezel (bib95) 2009; 88 Levkovitch-Verbin, Spierer, Vander, Dardik (bib47) 2011; 249 Nakazawa, Nakazawa, Matsubara, Noda, Hisatomi, She (bib56) 2006; 26 Nguyen, Soto, Kim, Bushong, Oglesby, Valiente-Soriano (bib59) 2011; 108 Bosco, Steele, Vetter (bib11) 2011; 519 Streit, Xue (bib77) 2014; 29 Johnson, Jia, Cepurna, Doser, Morrison (bib40) 2007; 48 Grieshaber, Orgul, Schoetzau, Flammer (bib28) 2007; 16 Pena, Varela, Ricard, Hernandez (bib63) 1999; 68 del Zoppo (bib21) 2012; 1268 Howell, Soto, Ryan, Graham, Smith, John (bib33) 2013; 10 Huang, Parlier, Shen, Lutty, Vinores (bib35) 2013; 8 Kuehn (bib42) 2014; 23 Howell, Soto, Zhu, Ryan, Macalinao, Sousa (bib34) 2012; 122 Ward, Dexter, Crichton (bib94) 2015; 7 Bosco, Crish, Steele, Romero, Inman, Horner (bib8) 2012 Seitz, Ohlmann, Tamm (bib70) 2013; 353 Mossböck, Weger, Moray, Renner, Haller-Schober, Mattes (bib55) 2006; 20 Wang, Xu, Yang (bib93) 2006; 86 Yuan, Neufeld (bib102) 2000; 32 Nickells, Howell, Soto, John (bib60) 2012; 35 Choi, Park, Kim, Kim (bib14) 2007; 38 Baneke, Lim, Stanford (bib6) 2015 Jeoung, Park, Kim, Kang, Kang, Kim (bib38) 2008; 115 Law, Choe, Caprioli (bib45) 2001; 132 Nikolskaya, Nikolsky, Serebryiskaya, Zvereva, Sviridov, Dezso (bib61) 2009; 2 Bosco, Romero, Ambati, Vetter (bib10) 2015; 99 Wakefield, Lloyd (bib89) 1992; 4 Wang, Shen, Wei, Lin, Feng, Yang (bib92) 2012; 18 Overby, Bertrand, Tektas, Boussommier-Calleja, Schicht, Ethier (bib62) 2014; 55 Bosco, Inman, Steele, Wu, Soto, Marsh-Armstrong (bib9) 2008; 49 Levkovitch-Verbin, Kalev-Landoy, Habot-Wilner, Melamed (bib46) 2006; 124 Luo, Yang, Kain, Powell, Kuehn, Tezel (bib51) 2010; 51 Roh, Zhang, Murakami, Thanos, Lee, Vavvas (bib67) 2012; 7 Su, Li, Jia, Zhuo (bib78) 2014; 9 Siddique, Suelves, Baheti, Foster (bib73) 2013; 58 Stasi, Nagel, Yang, Wang, Ren, Podos (bib75) 2006; 47 Baltmr, Duggan, Nizari, Salt, Cordeiro (bib5) 2010; 91 Wajant, Pfizenmaier, Scheurich (bib88) 2003; 10 Johnson, Doser, Cepurna, Dyck, Jia, Guo (bib39) 2011; 52 Gramlich, Ding, Zhu, Cook, Anderson, Kuehn (bib27) 2015; 3 Mills, Davis, Bushong, Boassa, Kim, Ellisman (bib54) 2015; 112 Shibuya, Meguro, Ota, Kashiwagi, Mabuchi, Iijima (bib71) 2008; 49 Križaj, Ryskamp, Tian, Tezel, Mitchell, Slepak (bib41) 2014; 39 Chen, Wang, Zhang (bib13) 2013; 126 Hwang, Kim, Kim, Sohn (bib37) 2014; 23 Soto, Howell (bib74) 2014; 4 Neufeld (bib58) 1999; 117 Wong, Huang, Li, Li, Zhang, Zhang (bib97) 2015; 10 Clark, Wilson, de Kater, Allingham, McCartney (bib15) 1995; 36 Uhler, Piltz-Seymour (bib86) 2008; 19 Xu, Chen, Forrester (bib99) 2009; 28 Bodh, Kumar, Raina, Ghosh, Thakar (bib7) 2011; 4 Sun, Qu, Jakobs (bib79) 2013; 61 Yuan, Neufeld (bib103) 2001; 64 del Zoppo (bib20) 2010; 1207 Yang, Patil, Yu, Gordon, Wax (bib100) 2001; 131 De Moraes, Liebmann, Ritch (bib19) 2012; 1 Taurone, Ripandelli, Pacella, Bianchi, Plateroti, De Vito (bib81) 2015; 11 Ren, Danias (bib66) 2010; 703 Airaksinen, Heijl (bib2) 1983; 61 Qu, Jakobs (bib64) 2013; 8 Raghunathan, Morgan, Park, Weber, Phinney, Murphy (bib65) 2015; 56 Wiggs (bib96) 2015; 134 Tamm, Dowling (bib104) 2017 Sawada, Kondo, Suzumura, Marunouchi (bib68) 1989; 491 Levkovitch-Verbin, Waserzoog, Vander, Makarovsky, Ilia (bib48) 2014; 124 Schneider, Fuchshofer (bib69) 2015 Aug 29; 142 Yang, Luo, Cai, Powell, Yu, Kuehn (bib101) 2011; 52 Drance (bib23) 1989; 33 Al-Gayyar, Elsherbiny (bib3) 2013; 24 Kur, Newman, Chan-Ling (bib43) 2012; 31 Xin, Gao, Wu, Sun (bib98) 2013; 19 Lin, Tsai, Chen, Shi, Hsu, Tsai (bib50) 2003; 17 Cueva Vargas, Osswald, Unsain, Aurousseau, Barker, Bowie (bib16) 2015; 35 Howell, Libby, John (bib30) 2008; 173 Howell, Macalinao, Sousa, Walden, Soto, Kneeland (bib31) 2011; 121 Takano, Shi, Shimizu, Funayama, Mashima, Yasuda (bib80) 2012; 154 Agarwal, Agarwal (bib1) 2012; 60 Shimazawa, Yamashima, Agarwal, Hara (bib72) 2005; 1053 Astafurov, Elhawy, Ren, Dong, Igboin, Hyman (bib4) 2014; 9 Kurvinen, Harju, Saari, Vesti (bib44) 2010; 248 Wallace, Murphy-Ullrich, Downs, O'Brien (bib90) 2014; 37 Bozkurt, Mesci, Irkec, Ozdag, Sanal, Arslan (bib12) 2012; 40 Huang, Zhang, Zhang (bib36) 2009; 2 Hostenbach, Cambron, D'haeseleer, Kooijman, De Keyser (bib29) 2014; 565 Tezel, Yang, Luo, Kain, Powell, Kuehn (bib85) 2010; 51 Dai, Khaw, Yin, Li, Raisman, Li (bib18) 2012; 60 Doudevski, Rostagno, Cowman, Liebmann, Ritch, Ghiso (bib22) 2014; 55 Gordon, Piltz-Seymour (bib26) 1997; 6 Stevens, Allen, Vazquez, Howell, Christopherson, Nouri (bib76) 2007; 131 Naskar, Wissing, Thanos (bib57) 2002; 43 Tezel, Wax (bib84) 2004; 15 Howell, MacNicoll, Braine, Soto, Macalinao, Sousa (bib32) 2014; 71 Lye-Barthel, Sun, Jakobs (bib52) 2013; 54 Dubey, Hejtmancik, Krishnadas, Sharmila, Haripriya, Sundaresan (bib24) 2015 Seitz (10.1016/j.exer.2017.02.014_bib70) 2013; 353 Nguyen (10.1016/j.exer.2017.02.014_bib59) 2011; 108 Wong (10.1016/j.exer.2017.02.014_bib97) 2015; 10 Tezel (10.1016/j.exer.2017.02.014_bib83) 2008; 173 Roh (10.1016/j.exer.2017.02.014_bib67) 2012; 7 Su (10.1016/j.exer.2017.02.014_bib78) 2014; 9 Yuan (10.1016/j.exer.2017.02.014_bib102) 2000; 32 Mossböck (10.1016/j.exer.2017.02.014_bib55) 2006; 20 Kur (10.1016/j.exer.2017.02.014_bib43) 2012; 31 Johnson (10.1016/j.exer.2017.02.014_bib40) 2007; 48 Vohra (10.1016/j.exer.2017.02.014_bib87) 2013; 58 Levkovitch-Verbin (10.1016/j.exer.2017.02.014_bib48) 2014; 124 Wang (10.1016/j.exer.2017.02.014_bib93) 2006; 86 Tamm (10.1016/j.exer.2017.02.014_bib104) 2017 Mac Nair (10.1016/j.exer.2017.02.014_bib53) 2014; 11 Howell (10.1016/j.exer.2017.02.014_bib33) 2013; 10 Bozkurt (10.1016/j.exer.2017.02.014_bib12) 2012; 40 Kurvinen (10.1016/j.exer.2017.02.014_bib44) 2010; 248 Wakefield (10.1016/j.exer.2017.02.014_bib89) 1992; 4 Bosco (10.1016/j.exer.2017.02.014_bib9) 2008; 49 Ren (10.1016/j.exer.2017.02.014_bib66) 2010; 703 Levkovitch-Verbin (10.1016/j.exer.2017.02.014_bib47) 2011; 249 Agarwal (10.1016/j.exer.2017.02.014_bib1) 2012; 60 Stevens (10.1016/j.exer.2017.02.014_bib76) 2007; 131 Wallace (10.1016/j.exer.2017.02.014_bib90) 2014; 37 Law (10.1016/j.exer.2017.02.014_bib45) 2001; 132 Levkovitch-Verbin (10.1016/j.exer.2017.02.014_bib46) 2006; 124 Lin (10.1016/j.exer.2017.02.014_bib50) 2003; 17 Taurone (10.1016/j.exer.2017.02.014_bib81) 2015; 11 Neufeld (10.1016/j.exer.2017.02.014_bib58) 1999; 117 Luo (10.1016/j.exer.2017.02.014_bib51) 2010; 51 De Moraes (10.1016/j.exer.2017.02.014_bib19) 2012; 1 Siddique (10.1016/j.exer.2017.02.014_bib73) 2013; 58 Bosco (10.1016/j.exer.2017.02.014_bib11) 2011; 519 Drance (10.1016/j.exer.2017.02.014_bib23) 1989; 33 Yang (10.1016/j.exer.2017.02.014_bib100) 2001; 131 Baneke (10.1016/j.exer.2017.02.014_bib6) 2015 Tezel (10.1016/j.exer.2017.02.014_bib85) 2010; 51 Cueva Vargas (10.1016/j.exer.2017.02.014_bib16) 2015; 35 Hwang (10.1016/j.exer.2017.02.014_bib37) 2014; 23 Nickells (10.1016/j.exer.2017.02.014_bib60) 2012; 35 Mills (10.1016/j.exer.2017.02.014_bib54) 2015; 112 Levkovitch-Verbin (10.1016/j.exer.2017.02.014_bib49) 2014; 252 Overby (10.1016/j.exer.2017.02.014_bib62) 2014; 55 Dubey (10.1016/j.exer.2017.02.014_bib24) 2015 Howell (10.1016/j.exer.2017.02.014_bib31) 2011; 121 da Fonseca (10.1016/j.exer.2017.02.014_bib17) 2014; 8 del Zoppo (10.1016/j.exer.2017.02.014_bib20) 2010; 1207 Sun (10.1016/j.exer.2017.02.014_bib79) 2013; 61 Dai (10.1016/j.exer.2017.02.014_bib18) 2012; 60 Yang (10.1016/j.exer.2017.02.014_bib101) 2011; 52 Stasi (10.1016/j.exer.2017.02.014_bib75) 2006; 47 Wajant (10.1016/j.exer.2017.02.014_bib88) 2003; 10 Wang (10.1016/j.exer.2017.02.014_bib92) 2012; 18 Streit (10.1016/j.exer.2017.02.014_bib77) 2014; 29 Jeoung (10.1016/j.exer.2017.02.014_bib38) 2008; 115 Takano (10.1016/j.exer.2017.02.014_bib80) 2012; 154 del Zoppo (10.1016/j.exer.2017.02.014_bib21) 2012; 1268 Raghunathan (10.1016/j.exer.2017.02.014_bib65) 2015; 56 Johnson (10.1016/j.exer.2017.02.014_bib39) 2011; 52 Wallace (10.1016/j.exer.2017.02.014_bib91) 2015; 31 Howell (10.1016/j.exer.2017.02.014_bib32) 2014; 71 Xu (10.1016/j.exer.2017.02.014_bib99) 2009; 28 Wiggs (10.1016/j.exer.2017.02.014_bib96) 2015; 134 Križaj (10.1016/j.exer.2017.02.014_bib41) 2014; 39 Fan (10.1016/j.exer.2017.02.014_bib25) 2010; 1 Gramlich (10.1016/j.exer.2017.02.014_bib27) 2015; 3 Hostenbach (10.1016/j.exer.2017.02.014_bib29) 2014; 565 Bodh (10.1016/j.exer.2017.02.014_bib7) 2011; 4 Airaksinen (10.1016/j.exer.2017.02.014_bib2) 1983; 61 Wax (10.1016/j.exer.2017.02.014_bib95) 2009; 88 Grieshaber (10.1016/j.exer.2017.02.014_bib28) 2007; 16 Howell (10.1016/j.exer.2017.02.014_bib30) 2008; 173 Soto (10.1016/j.exer.2017.02.014_bib74) 2014; 4 Lye-Barthel (10.1016/j.exer.2017.02.014_bib52) 2013; 54 Chen (10.1016/j.exer.2017.02.014_bib13) 2013; 126 Yuan (10.1016/j.exer.2017.02.014_bib103) 2001; 64 Huang (10.1016/j.exer.2017.02.014_bib36) 2009; 2 Schneider (10.1016/j.exer.2017.02.014_bib69) 2015; 142 Tezel (10.1016/j.exer.2017.02.014_bib84) 2004; 15 Clark (10.1016/j.exer.2017.02.014_bib15) 1995; 36 Qu (10.1016/j.exer.2017.02.014_bib64) 2013; 8 Shimazawa (10.1016/j.exer.2017.02.014_bib72) 2005; 1053 Sawada (10.1016/j.exer.2017.02.014_bib68) 1989; 491 Uhler (10.1016/j.exer.2017.02.014_bib86) 2008; 19 Bosco (10.1016/j.exer.2017.02.014_bib8) 2012 Ward (10.1016/j.exer.2017.02.014_bib94) 2015; 7 Naskar (10.1016/j.exer.2017.02.014_bib57) 2002; 43 Astafurov (10.1016/j.exer.2017.02.014_bib4) 2014; 9 Doudevski (10.1016/j.exer.2017.02.014_bib22) 2014; 55 Pena (10.1016/j.exer.2017.02.014_bib63) 1999; 68 Shibuya (10.1016/j.exer.2017.02.014_bib71) 2008; 49 Huang (10.1016/j.exer.2017.02.014_bib35) 2013; 8 Al-Gayyar (10.1016/j.exer.2017.02.014_bib3) 2013; 24 Howell (10.1016/j.exer.2017.02.014_bib34) 2012; 122 Nikolskaya (10.1016/j.exer.2017.02.014_bib61) 2009; 2 Baltmr (10.1016/j.exer.2017.02.014_bib5) 2010; 91 Gordon (10.1016/j.exer.2017.02.014_bib26) 1997; 6 Bosco (10.1016/j.exer.2017.02.014_bib10) 2015; 99 Nakazawa (10.1016/j.exer.2017.02.014_bib56) 2006; 26 Tektas (10.1016/j.exer.2017.02.014_bib82) 2011; 36 Kuehn (10.1016/j.exer.2017.02.014_bib42) 2014; 23 Choi (10.1016/j.exer.2017.02.014_bib14) 2007; 38 Xin (10.1016/j.exer.2017.02.014_bib98) 2013; 19 21246546 - J Comp Neurol. 2011 Mar 1;519(4):599-620 22994231 - Ann N Y Acad Sci. 2012 Sep;1268:127-33 23217584 - Surv Ophthalmol. 2013 Jan-Feb;58(1):1-10 19426536 - BMC Med Genomics. 2009 May 09;2:24 22831837 - Am J Ophthalmol. 2012 Nov;154(5):825-832.e1 22824592 - Indian J Ophthalmol. 2012 Jul;60(4):255-61 22524788 - Annu Rev Neurosci. 2012;35:153-79 26107132 - Asia Pac J Ophthalmol (Phila). 2012 Mar-Apr;1(2):105-12 25028360 - Invest Ophthalmol Vis Sci. 2014 Jul 15;55(8):4922-33 20538986 - Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5697-707 10975909 - Glia. 2000 Oct;32(1):42-50 25275909 - J Glaucoma. 2014 Oct-Nov;23(8 Suppl 1):S59-61 10448748 - Arch Ophthalmol. 1999 Aug;117(8):1050-6 23768921 - Surv Ophthalmol. 2013 Jul-Aug;58(4):311-20 23650091 - Glia. 2013 Aug;61(8):1218-35 16138112 - Eye (Lond). 2006 Sep;20(9):1040-3 26240339 - Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10509-14 21917936 - Invest Ophthalmol Vis Sci. 2011 Oct 31;52(11):8442-54 6880632 - Acta Ophthalmol (Copenh). 1983 Apr;61(2):186-94 23826199 - PLoS One. 2013 Jun 27;8(6):e67094 25180891 - PLoS One. 2014 Sep 02;9(9):e104416 24908174 - Curr Opin Immunol. 2014 Aug;29:93-6 24727033 - Matrix Biol. 2014 Jul;37:174-82 25811482 - PLoS One. 2015 Mar 26;10(3):e0122184 23779255 - Cell Tissue Res. 2013 Aug;353(2):339-45 18301280 - Curr Opin Ophthalmol. 2008 Mar;19(2):89-94 19041474 - Ophthalmology. 2008 Dec;115(12):2132-40 17151265 - J Neurosci. 2006 Dec 6;26(49):12633-41 21575121 - Clin Exp Ophthalmol. 2012 May-Jun;40(4):e156-62 20800593 - Exp Eye Res. 2010 Nov;91(5):554-66 22426214 - J Clin Invest. 2012 Apr;122(4):1246-61 25132557 - Neurobiol Dis. 2014 Nov;71:44-52 9075084 - J Glaucoma. 1997 Feb;6(1):62-4 11391707 - J Neurosci Res. 2001 Jun 1;64(5):523-32 18929118 - Prog Brain Res. 2008;173:303-21 22952717 - PLoS One. 2012;7(8):e43602 25961695 - Front Biosci (Schol Ed). 2015 Jun 01;7:189-204 22802951 - PLoS One. 2012;7(7):e40065 21383504 - J Clin Invest. 2011 Apr;121(4):1429-44 25407441 - J Neuroinflammation. 2014 Nov 19;11:194 26321510 - Exp Eye Res. 2016 Jan;142:49-55 12579167 - Eye (Lond). 2003 Jan;17(1):31-4 26193921 - Invest Ophthalmol Vis Sci. 2015 Jul;56(8):4447-59 16681968 - Zhonghua Yi Xue Za Zhi. 2006 Mar 28;86(12):811-4 18385061 - Invest Ophthalmol Vis Sci. 2008 Apr;49(4):1437-46 17473733 - J Glaucoma. 2007 Mar;16(2):215-9 24144321 - Curr Eye Res. 2014 Feb;39(2):105-19 18929124 - Prog Brain Res. 2008;173:409-21 20635187 - Graefes Arch Clin Exp Ophthalmol. 2010 Dec;248(12):1771-5 16606878 - Arch Ophthalmol. 2006 Apr;124(4):520-6 23322566 - Invest Ophthalmol Vis Sci. 2013 Feb 01;54(2):909-17 18586872 - Invest Ophthalmol Vis Sci. 2008 Oct;49(10):4453-7 20955425 - Ann N Y Acad Sci. 2010 Oct;1207:46-9 16051195 - Brain Res. 2005 Aug 16;1053(1-2):185-94 23806181 - J Neuroinflammation. 2013 Jun 27;10:76 2655138 - Surv Ophthalmol. 1989 Mar-Apr;33(5):331-7 25992962 - J Vis Exp. 2015 May 11;(99):e52731 24128880 - Neurosci Lett. 2014 Apr 17;565:39-41 12202516 - Invest Ophthalmol Vis Sci. 2002 Sep;43(9):2962-8 17396692 - Ophthalmic Surg Lasers Imaging. 2007 Mar-Apr;38(2):118-25 17591886 - Invest Ophthalmol Vis Sci. 2007 Jul;48(7):3161-77 24993677 - Cold Spring Harb Perspect Med. 2014 Jul 03;4(8):null 20847120 - Invest Ophthalmol Vis Sci. 2011 Jan 25;52(1):504-18 25351602 - Mol Med Rep. 2015 Feb;11(2):1384-90 20484586 - Invest Ophthalmol Vis Sci. 2010 Oct;51(10):5071-82 11292402 - Am J Ophthalmol. 2001 Apr;131(4):421-6 21501078 - Curr Eye Res. 2011 May;36(5):442-8 26374513 - Acta Neuropathol Commun. 2015 Sep 15;3:56 25404894 - Front Cell Neurosci. 2014 Nov 03;8:362 22509108 - Mol Vis. 2012;18:779-85 12655295 - Cell Death Differ. 2003 Jan;10(1):45-65 9986739 - Exp Eye Res. 1999 Jan;68(1):29-40 19672464 - J Ocul Biol Dis Infor. 2009 Jun;2(2):78-83 15021215 - Curr Opin Ophthalmol. 2004 Apr;15(2):80-4 25849827 - Curr Eye Res. 2015;40(12):1218-24 21229256 - Graefes Arch Clin Exp Ophthalmol. 2011 Jun;249(6):849-57 24923557 - PLoS One. 2014 Jun 12;9(6):e99719 25093520 - J Glaucoma. 2014 Oct-Nov;23(8):547-52 26338321 - J Neurosci. 2015 Sep 2;35(35):12088-102 21199938 - Proc Natl Acad Sci U S A. 2011 Jan 18;108(3):1176-81 23608634 - Eur Cytokine Netw. 2013 Mar;24(1):27-36 24410139 - Int J Neurosci. 2014 Oct;124(10):755-61 26310163 - Prog Mol Biol Transl Sci. 2015;134:315-42 16505037 - Invest Ophthalmol Vis Sci. 2006 Mar;47(3):1024-9 20352036 - Ophthalmol Eye Dis. 2010 Mar 11;1:23-41 21948238 - Glia. 2012 Jan;60(1):13-28 25848892 - J Ocul Pharmacol Ther. 2015 Sep;31(7):386-95 1617154 - Cytokine. 1992 Jan;4(1):1-5 23977149 - PLoS One. 2013 Aug 20;8(8):e71808 21713239 - Oman J Ophthalmol. 2011 Jan;4(1):3-9 24550356 - Invest Ophthalmol Vis Sci. 2014 Apr 17;55(4):2491-9 19233171 - Exp Eye Res. 2009 Apr;88(4):825-30 19560552 - Prog Retin Eye Res. 2009 Sep;28(5):348-68 20711709 - Adv Exp Med Biol. 2010;703:95-104 18083105 - Cell. 2007 Dec 14;131(6):1164-78 2765895 - Brain Res. 1989 Jul 10;491(2):394-7 22580107 - Prog Retin Eye Res. 2012 Sep;31(5):377-406 23595396 - Chin Med J (Engl). 2013;126(8):1567-77 11530060 - Am J Ophthalmol. 2001 Sep;132(3):411-3 7843916 - Invest Ophthalmol Vis Sci. 1995 Feb;36(2):478-89 23559847 - Mol Vis. 2013;19:526-35 24566901 - Graefes Arch Clin Exp Ophthalmol. 2014 May;252(5):761-72 |
| References_xml | – volume: 68 start-page: 29 year: 1999 end-page: 40 ident: bib63 article-title: Enhanced tenascin expression associated with reactive astrocytes in human optic nerve heads with primary open angle glaucoma publication-title: Exp. Eye Res. – volume: 4 start-page: 1 year: 1992 end-page: 5 ident: bib89 article-title: The role of cytokines in the pathogenesis of inflammatory eye disease publication-title: Cytokine – start-page: 1 year: 2015 end-page: 7 ident: bib24 article-title: Evaluation of genetic polymorphisms in clusterin and tumor necrosis factor-alpha genes in south indian individuals with pseudoexfoliation syndrome publication-title: Curr. Eye Res. – volume: 126 start-page: 1567 year: 2013 end-page: 1577 ident: bib13 article-title: Neuroprotection in glaucoma: present and future publication-title: Chin. Med. J. Engl. – volume: 99 start-page: e52731 year: 2015 ident: bib10 article-title: In vivo dynamics of retinal microglial activation during neurodegeneration: confocal ophthalmoscopic imaging and cell morphometry in mouse glaucoma publication-title: J. Vis. Exp. – volume: 2 start-page: 78 year: 2009 end-page: 83 ident: bib36 article-title: The two sides of cytokine signaling and glaucomatous optic neuropathy publication-title: J. Ocul. Biol. Dis. Infor – volume: 36 start-page: 442 year: 2011 end-page: 448 ident: bib82 article-title: Morphological changes of trabeculectomy specimens in different kinds of uveitic glaucoma publication-title: Curr. Eye Res. – volume: 60 start-page: 255 year: 2012 end-page: 261 ident: bib1 article-title: Glaucomatous neurodegeneration: an eye on tumor necrosis factor-alpha publication-title: Indian J. Ophthalmol. – volume: 54 start-page: 909 year: 2013 end-page: 917 ident: bib52 article-title: Morphology of astrocytes in a glaucomatous optic nerve publication-title: Invest Ophthalmol. Vis. Sci. – volume: 249 start-page: 849 year: 2011 end-page: 857 ident: bib47 article-title: Similarities and differences between primary and secondary degeneration of the optic nerve and the effect of minocycline publication-title: Graefes Arch. Clin. Exp. Ophthalmol. – volume: 48 start-page: 3161 year: 2007 end-page: 3177 ident: bib40 article-title: Global changes in optic nerve head gene expression after exposure to elevated intraocular pressure in a rat glaucoma model publication-title: Invest Ophthalmol. Vis. Sci. – volume: 117 start-page: 1050 year: 1999 end-page: 1056 ident: bib58 article-title: Microglia in the optic nerve head and the region of parapapillary chorioretinal atrophy in glaucoma publication-title: Arch. Ophthalmol. – volume: 10 start-page: e0122184 year: 2015 ident: bib97 article-title: T-helper1/T-helper2 cytokine imbalance in the iris of patients with glaucoma publication-title: PLoS One – volume: 8 start-page: e71808 year: 2013 ident: bib35 article-title: VEGF receptor blockade markedly reduces retinal microglia/macrophage infiltration into laser-induced CNV publication-title: PLoS One – volume: 519 start-page: 599 year: 2011 end-page: 620 ident: bib11 article-title: Early microglia activation in a mouse model of chronic glaucoma publication-title: J. Comp. Neurol. – volume: 8 start-page: 362 year: 2014 ident: bib17 article-title: The impact of microglial activation on blood-brain barrier in brain diseases publication-title: Front. Cell Neurosci. – volume: 353 start-page: 339 year: 2013 end-page: 345 ident: bib70 article-title: The role of Müller glia and microglia in glaucoma publication-title: Cell Tissue Res. – volume: 1 start-page: 105 year: 2012 end-page: 112 ident: bib19 article-title: Predictive factors within the optic nerve complex for glaucoma progression: disc hemorrhage and parapapillary atrophy publication-title: Asia Pac J. Ophthalmol. (Phila) – volume: 7 start-page: e40065 year: 2012 ident: bib67 article-title: Etanercept, a widely used inhibitor of tumor necrosis factor-α (TNF-α), prevents retinal ganglion cell loss in a rat model of glaucoma publication-title: PLoS One – volume: 24 start-page: 27 year: 2013 end-page: 36 ident: bib3 article-title: Contribution of TNF-α to the development of retinal neurodegenerative disorders publication-title: Eur. Cytokine Netw. – volume: 26 start-page: 12633 year: 2006 end-page: 12641 ident: bib56 article-title: Tumor necrosis factor-alpha mediates oligodendrocyte death and delayed retinal ganglion cell loss in a mouse model of glaucoma publication-title: J. Neurosci. – volume: 2 start-page: 24 year: 2009 ident: bib61 article-title: Network analysis of human glaucomatous optic nerve head astrocytes publication-title: BMC Med. Genomics – volume: 86 start-page: 811 year: 2006 end-page: 814 ident: bib93 article-title: The prevalence of disc hemorrhage and papillary atrophy in Beijing Eye Study publication-title: Zhonghua Yi Xue Za Zhi – volume: 29 start-page: 93 year: 2014 end-page: 96 ident: bib77 article-title: Human CNS immune senescence and neurodegeneration publication-title: Curr. Opin. Immunol. – volume: 18 start-page: 779 year: 2012 end-page: 785 ident: bib92 article-title: Polymorphism in the TNF-α(-863) locus associated with reduced risk of primary open angle glaucoma publication-title: Mol. Vis. – volume: 1 start-page: 23 year: 2010 end-page: 41 ident: bib25 article-title: Early involvement of immune/inflammatory response genes in retinal degeneration in DBA/2J mice publication-title: Ophthalmol. Eye Dis. – volume: 47 start-page: 1024 year: 2006 end-page: 1029 ident: bib75 article-title: Complement component 1Q (C1Q) upregulation in retina of murine, primate, and human glaucomatous eyes publication-title: Invest Ophthalmol. Vis. Sci. – volume: 1268 start-page: 127 year: 2012 end-page: 133 ident: bib21 article-title: Aging and the neurovascular unit publication-title: Ann. N. Y. Acad. Sci. – volume: 173 start-page: 303 year: 2008 end-page: 321 ident: bib30 article-title: Mouse genetic models: an ideal system for understanding glaucomatous neurodegeneration and neuroprotection publication-title: Prog. Brain Res. – volume: 61 start-page: 186 year: 1983 end-page: 194 ident: bib2 article-title: Visual field and retinal nerve fibre layer in early glaucoma after optic disc haemorrhage publication-title: Acta Ophthalmol. (Copenh) – volume: 132 start-page: 411 year: 2001 end-page: 413 ident: bib45 article-title: Optic disk characteristics before the occurrence of disk hemorrhage in glaucoma patients publication-title: Am. J. Ophthalmol. – volume: 91 start-page: 554 year: 2010 end-page: 566 ident: bib5 article-title: Neuroprotection in glaucoma - is there a future role? publication-title: Exp. Eye Res. – volume: 52 start-page: 504 year: 2011 end-page: 518 ident: bib39 article-title: Cell proliferation and interleukin-6-type cytokine signaling are implicated by gene expression responses in early optic nerve head injury in rat glaucoma publication-title: Invest Ophthalmol. Vis. Sci. – volume: 37 start-page: 174 year: 2014 end-page: 182 ident: bib90 article-title: The role of matricellular proteins in glaucoma publication-title: Matrix Biol. – volume: 33 start-page: 331 year: 1989 end-page: 337 ident: bib23 article-title: Disc hemorrhages in the glaucomas publication-title: Surv. Ophthalmol. – volume: 19 start-page: 89 year: 2008 end-page: 94 ident: bib86 article-title: Optic disc hemorrhages in glaucoma and ocular hypertension: implications and recommendations publication-title: Curr. Opin. Ophthalmol. – volume: 49 start-page: 1437 year: 2008 end-page: 1446 ident: bib9 article-title: Reduced retina microglial activation and improved optic nerve integrity with minocycline treatment in the DBA/2J mouse model of glaucoma publication-title: Invest Ophthalmol. Vis. Sci. – volume: 17 start-page: 31 year: 2003 end-page: 34 ident: bib50 article-title: Association of tumour necrosis factor alpha -308 gene polymorphism with primary open-angle glaucoma in Chinese publication-title: Eye (Lond) – volume: 1207 start-page: 46 year: 2010 end-page: 49 ident: bib20 article-title: The neurovascular unit, matrix proteases, and innate inflammation publication-title: Ann. N. Y. Acad. Sci. – volume: 6 start-page: 62 year: 1997 end-page: 64 ident: bib26 article-title: The significance of optic disc hemorrhages in glaucoma publication-title: J. Glaucoma – volume: 1053 start-page: 185 year: 2005 end-page: 194 ident: bib72 article-title: Neuroprotective effects of minocycline against in vitro and in vivo retinal ganglion cell damage publication-title: Brain Res. – volume: 115 start-page: 2132 year: 2008 end-page: 2140 ident: bib38 article-title: Optic disc hemorrhage may be associated with retinal nerve fiber loss in otherwise normal eyes publication-title: Ophthalmology – volume: 58 start-page: 311 year: 2013 end-page: 320 ident: bib87 article-title: The role of inflammation in the pathogenesis of glaucoma publication-title: Surv. Ophthalmol. – volume: 124 start-page: 755 year: 2014 end-page: 761 ident: bib48 article-title: Minocycline mechanism of neuroprotection involves the Bcl-2 gene family in optic nerve transection publication-title: Int. J. Neurosci. – volume: 61 start-page: 1218 year: 2013 end-page: 1235 ident: bib79 article-title: Reversible reactivity by optic nerve astrocytes publication-title: Glia – volume: 20 start-page: 1040 year: 2006 end-page: 1043 ident: bib55 article-title: TNF-alpha promoter polymorphisms and primary open-angle glaucoma publication-title: Eye (Lond) – volume: 10 start-page: 45 year: 2003 end-page: 65 ident: bib88 article-title: Tumor necrosis factor signaling publication-title: Cell Death Differ. – volume: 248 start-page: 1771 year: 2010 end-page: 1775 ident: bib44 article-title: Altered temporal peripapillary retinal flow in patients with disc hemorrhages publication-title: Graefes Arch. Clin. Exp. Ophthalmol. – start-page: e43602 year: 2012 ident: bib8 article-title: Early reduction of microglia activation by irradiation in a model of chronic glaucoma publication-title: PLoS One. U. S. – volume: 9 start-page: e104416 year: 2014 ident: bib4 article-title: Oral microbiome link to neurodegeneration in glaucoma publication-title: PLoS One – start-page: 1 year: 2017 end-page: 4 ident: bib104 article-title: Astrocytes and glaucomatous neurodegeneration publication-title: Exper. Eye Res. – volume: 39 start-page: 105 year: 2014 end-page: 119 ident: bib41 article-title: From mechanosensitivity to inflammatory responses: new players in the pathology of glaucoma publication-title: Curr. Eye Res. – volume: 10 start-page: 76 year: 2013 ident: bib33 article-title: Deficiency of complement component 5 ameliorates glaucoma in DBA/2J mice publication-title: J. Neuroinflammation – volume: 565 start-page: 39 year: 2014 end-page: 41 ident: bib29 article-title: Astrocyte loss and astrogliosis in neuroinflammatory disorders publication-title: Neurosci. Lett. – volume: 55 start-page: 2491 year: 2014 end-page: 2499 ident: bib22 article-title: Clusterin and complement activation in exfoliation glaucoma publication-title: Invest Ophthalmol. Vis. Sci. – volume: 16 start-page: 215 year: 2007 end-page: 219 ident: bib28 article-title: Relationship between retinal glial cell activation in glaucoma and vascular dysregulation publication-title: J. Glaucoma – volume: 35 start-page: 12088 year: 2015 end-page: 12102 ident: bib16 article-title: Soluble tumor necrosis factor alpha promotes retinal ganglion cell death in glaucoma via calcium-permeable AMPA receptor activation publication-title: J. Neurosci. – volume: 131 start-page: 421 year: 2001 end-page: 426 ident: bib100 article-title: T cell subsets and sIL-2R/IL-2 levels in patients with glaucoma publication-title: Am. J. Ophthalmol. – volume: 124 start-page: 520 year: 2006 end-page: 526 ident: bib46 article-title: Minocycline delays death of retinal ganglion cells in experimental glaucoma and after optic nerve transection publication-title: Arch. Ophthalmol. – volume: 703 start-page: 95 year: 2010 end-page: 104 ident: bib66 article-title: A role for complement in glaucoma? publication-title: Adv. Exp. Med. Biol. – volume: 31 start-page: 386 year: 2015 end-page: 395 ident: bib91 article-title: The function of matricellular proteins in the lamina cribrosa and trabecular meshwork in glaucoma publication-title: J. Ocul. Pharmacol. Ther. – volume: 43 start-page: 2962 year: 2002 end-page: 2968 ident: bib57 article-title: Detection of early neuron degeneration and accompanying microglial responses in publication-title: Invest Ophthalmol. Vis. Sci. – volume: 55 start-page: 4922 year: 2014 end-page: 4933 ident: bib62 article-title: Ultrastructural changes associated with dexamethasone-induced ocular hypertension in mice publication-title: Invest Ophthalmol. Vis. Sci. – start-page: 1 year: 2015 end-page: 13 ident: bib6 article-title: The pathogenesis of raised intraocular pressure in uveitis publication-title: Curr. Eye Res. – volume: 121 start-page: 1429 year: 2011 end-page: 1444 ident: bib31 article-title: Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma publication-title: J. Clin. Invest – volume: 7 start-page: 189 year: 2015 end-page: 204 ident: bib94 article-title: Ageing, neuroinflammation and neurodegeneration publication-title: Front. Biosci. Sch. Ed. – volume: 11 start-page: 194 year: 2014 ident: bib53 article-title: Tumor necrosis factor alpha has an early protective effect on retinal ganglion cells after optic nerve crush publication-title: J. Neuroinflammation – volume: 52 start-page: 8442 year: 2011 end-page: 8454 ident: bib101 article-title: Neurodegenerative and inflammatory pathway components linked to TNF-α/TNFR1 signaling in the glaucomatous human retina publication-title: Invest Ophthalmol. Vis. Sci. – volume: 491 start-page: 394 year: 1989 end-page: 397 ident: bib68 article-title: Production of tumor necrosis factor-alpha by microglia and astrocytes in culture publication-title: Brain Res. – volume: 108 start-page: 1176 year: 2011 end-page: 1181 ident: bib59 article-title: Myelination transition zone astrocytes are constitutively phagocytic and have synuclein dependent reactivity in glaucoma publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 35 start-page: 153 year: 2012 end-page: 179 ident: bib60 article-title: Under pressure: cellular and molecular responses during glaucoma, a common neurodegeneration with axonopathy publication-title: Annu. Rev. Neurosci. – volume: 51 start-page: 5071 year: 2010 end-page: 5082 ident: bib85 article-title: Oxidative stress and the regulation of complement activation in human glaucoma publication-title: Invest Ophthalmol. Vis. Sci. – volume: 131 start-page: 1164 year: 2007 end-page: 1178 ident: bib76 article-title: The classical complement cascade mediates CNS synapse elimination publication-title: Cell – volume: 64 start-page: 523 year: 2001 end-page: 532 ident: bib103 article-title: Activated microglia in the human glaucomatous optic nerve head publication-title: J. Neurosci. Res. – volume: 15 start-page: 80 year: 2004 end-page: 84 ident: bib84 article-title: The immune system and glaucoma publication-title: Curr. Opin. Ophthalmol. – volume: 252 start-page: 761 year: 2014 end-page: 772 ident: bib49 article-title: Minocycline upregulates pro-survival genes and downregulates pro-apoptotic genes in experimental glaucoma publication-title: Graefes Arch. Clin. Exp. Ophthalmol. – volume: 112 start-page: 10509 year: 2015 end-page: 10514 ident: bib54 article-title: Astrocytes phagocytose focal dystrophies from shortening myelin segments in the optic nerve of Xenopus laevis at metamorphosis publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 9 start-page: e99719 year: 2014 ident: bib78 article-title: Rapamycin is neuroprotective in a rat chronic hypertensive glaucoma model publication-title: PLoS One – volume: 19 start-page: 526 year: 2013 end-page: 535 ident: bib98 article-title: Roles of tumor necrosis factor alpha gene polymorphisms, tumor necrosis factor alpha level in aqueous humor, and the risks of open angle glaucoma: a meta-analysis publication-title: Mol. Vis. – volume: 71 start-page: 44 year: 2014 end-page: 52 ident: bib32 article-title: Combinatorial targeting of early pathways profoundly inhibits neurodegeneration in a mouse model of glaucoma publication-title: Neurobiol. Dis. – volume: 88 start-page: 825 year: 2009 end-page: 830 ident: bib95 article-title: Immunoregulation of retinal ganglion cell fate in glaucoma publication-title: Exp. Eye Res. – volume: 58 start-page: 1 year: 2013 end-page: 10 ident: bib73 article-title: Glaucoma and uveitis publication-title: Surv. Ophthalmol. – volume: 122 start-page: 1246 year: 2012 end-page: 1261 ident: bib34 article-title: Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma publication-title: J. Clin. Invest – volume: 31 start-page: 377 year: 2012 end-page: 406 ident: bib43 article-title: Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease publication-title: Prog. Retin Eye Res. – volume: 23 start-page: S59 year: 2014 end-page: S61 ident: bib42 article-title: Immune phenomena in glaucoma and conformational disorders: why is the second eye not involved? publication-title: J. Glaucoma – volume: 3 start-page: 56 year: 2015 ident: bib27 article-title: Adoptive transfer of immune cells from glaucomatous mice provokes retinal ganglion cell loss in recipients publication-title: Acta Neuropathol. Commun. – volume: 154 year: 2012 ident: bib80 article-title: Association of Toll-like receptor 4 gene polymorphisms in Japanese subjects with primary open-angle, normal-tension, and exfoliation glaucoma publication-title: Am. J. Ophthalmol. – volume: 4 year: 2014 ident: bib74 article-title: The complex role of neuroinflammation in glaucoma publication-title: Cold Spring Harb. Perspect. Med. – volume: 56 start-page: 4447 year: 2015 end-page: 4459 ident: bib65 article-title: Dexamethasone stiffens trabecular meshwork, trabecular meshwork cells, and matrix publication-title: Invest Ophthalmol. Vis. Sci. – volume: 40 year: 2012 ident: bib12 article-title: Association of tumour necrosis factor-alpha -308 G/A polymorphism with primary open-angle glaucoma publication-title: Clin. Exp. Ophthalmol. – volume: 38 start-page: 118 year: 2007 end-page: 125 ident: bib14 article-title: Retinal nerve fiber layer thickness evaluation using optical coherence tomography in eyes with optic disc hemorrhage publication-title: Ophthalmic Surg. Lasers Imaging – volume: 8 start-page: e67094 year: 2013 ident: bib64 article-title: The time course of gene expression during reactive gliosis in the optic nerve publication-title: PLoS One – volume: 49 start-page: 4453 year: 2008 end-page: 4457 ident: bib71 article-title: Association of Toll-like receptor 4 gene polymorphisms with normal tension glaucoma publication-title: Invest Ophthalmol. Vis. Sci. – volume: 11 start-page: 1384 year: 2015 end-page: 1390 ident: bib81 article-title: Potential regulatory molecules in the human trabecular meshwork of patients with glaucoma: immunohistochemical profile of a number of inflammatory cytokines publication-title: Mol. Med. Rep. – volume: 23 start-page: 547 year: 2014 end-page: 552 ident: bib37 article-title: Changes in retinal nerve fiber layer thickness after optic disc hemorrhage in glaucomatous eyes publication-title: J. Glaucoma – volume: 36 start-page: 478 year: 1995 end-page: 489 ident: bib15 article-title: Dexamethasone-induced ocular hypertension in perfusion-cultured human eyes publication-title: Invest Ophthalmol. Vis. Sci. – volume: 142 start-page: 49 year: 2015 Aug 29 end-page: 55 ident: bib69 article-title: The role of astrocytes in optic nerve head fibrosis in glaucoma publication-title: Exp. Eye Res. – volume: 28 start-page: 348 year: 2009 end-page: 368 ident: bib99 article-title: Para-inflammation in the aging retina publication-title: Prog. Retin Eye Res. – volume: 134 start-page: 315 year: 2015 end-page: 342 ident: bib96 article-title: Glaucoma genes and mechanisms publication-title: Prog. Mol. Biol. Transl. Sci. – volume: 51 start-page: 5697 year: 2010 end-page: 5707 ident: bib51 article-title: Glaucomatous tissue stress and the regulation of immune response through glial Toll-like receptor signaling publication-title: Invest Ophthalmol. Vis. Sci. – volume: 4 start-page: 3 year: 2011 end-page: 9 ident: bib7 article-title: Inflammatory glaucoma publication-title: Oman J. Ophthalmol. – volume: 60 start-page: 13 year: 2012 end-page: 28 ident: bib18 article-title: Structural basis of glaucoma: the fortified astrocytes of the optic nerve head are the target of raised intraocular pressure publication-title: Glia – volume: 173 start-page: 409 year: 2008 end-page: 421 ident: bib83 article-title: TNF-alpha signaling in glaucomatous neurodegeneration publication-title: Prog. Brain Res. – volume: 32 start-page: 42 year: 2000 end-page: 50 ident: bib102 article-title: Tumor necrosis factor-alpha: a potentially neurodestructive cytokine produced by glia in the human glaucomatous optic nerve head publication-title: Glia – volume: 38 start-page: 118 issue: 2 year: 2007 ident: 10.1016/j.exer.2017.02.014_bib14 article-title: Retinal nerve fiber layer thickness evaluation using optical coherence tomography in eyes with optic disc hemorrhage publication-title: Ophthalmic Surg. Lasers Imaging doi: 10.3928/15428877-20070301-06 – volume: 6 start-page: 62 issue: 1 year: 1997 ident: 10.1016/j.exer.2017.02.014_bib26 article-title: The significance of optic disc hemorrhages in glaucoma publication-title: J. Glaucoma – volume: 43 start-page: 2962 issue: 9 year: 2002 ident: 10.1016/j.exer.2017.02.014_bib57 article-title: Detection of early neuron degeneration and accompanying microglial responses in publication-title: Invest Ophthalmol. Vis. Sci. – volume: 9 start-page: e99719 issue: 6 year: 2014 ident: 10.1016/j.exer.2017.02.014_bib78 article-title: Rapamycin is neuroprotective in a rat chronic hypertensive glaucoma model publication-title: PLoS One doi: 10.1371/journal.pone.0099719 – volume: 131 start-page: 1164 issue: 6 year: 2007 ident: 10.1016/j.exer.2017.02.014_bib76 article-title: The classical complement cascade mediates CNS synapse elimination publication-title: Cell doi: 10.1016/j.cell.2007.10.036 – volume: 10 start-page: e0122184 issue: 3 year: 2015 ident: 10.1016/j.exer.2017.02.014_bib97 article-title: T-helper1/T-helper2 cytokine imbalance in the iris of patients with glaucoma publication-title: PLoS One doi: 10.1371/journal.pone.0122184 – volume: 124 start-page: 755 issue: 10 year: 2014 ident: 10.1016/j.exer.2017.02.014_bib48 article-title: Minocycline mechanism of neuroprotection involves the Bcl-2 gene family in optic nerve transection publication-title: Int. J. Neurosci. doi: 10.3109/00207454.2013.878340 – volume: 58 start-page: 311 issue: 4 year: 2013 ident: 10.1016/j.exer.2017.02.014_bib87 article-title: The role of inflammation in the pathogenesis of glaucoma publication-title: Surv. Ophthalmol. doi: 10.1016/j.survophthal.2012.08.010 – volume: 58 start-page: 1 issue: 1 year: 2013 ident: 10.1016/j.exer.2017.02.014_bib73 article-title: Glaucoma and uveitis publication-title: Surv. Ophthalmol. doi: 10.1016/j.survophthal.2012.04.006 – volume: 26 start-page: 12633 issue: 49 year: 2006 ident: 10.1016/j.exer.2017.02.014_bib56 article-title: Tumor necrosis factor-alpha mediates oligodendrocyte death and delayed retinal ganglion cell loss in a mouse model of glaucoma publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.2801-06.2006 – volume: 1053 start-page: 185 issue: 1–2 year: 2005 ident: 10.1016/j.exer.2017.02.014_bib72 article-title: Neuroprotective effects of minocycline against in vitro and in vivo retinal ganglion cell damage publication-title: Brain Res. doi: 10.1016/j.brainres.2005.06.053 – volume: 24 start-page: 27 issue: 1 year: 2013 ident: 10.1016/j.exer.2017.02.014_bib3 article-title: Contribution of TNF-α to the development of retinal neurodegenerative disorders publication-title: Eur. Cytokine Netw. doi: 10.1684/ecn.2013.0334 – volume: 88 start-page: 825 issue: 4 year: 2009 ident: 10.1016/j.exer.2017.02.014_bib95 article-title: Immunoregulation of retinal ganglion cell fate in glaucoma publication-title: Exp. Eye Res. doi: 10.1016/j.exer.2009.02.005 – volume: 3 start-page: 56 year: 2015 ident: 10.1016/j.exer.2017.02.014_bib27 article-title: Adoptive transfer of immune cells from glaucomatous mice provokes retinal ganglion cell loss in recipients publication-title: Acta Neuropathol. Commun. doi: 10.1186/s40478-015-0234-y – volume: 115 start-page: 2132 issue: 12 year: 2008 ident: 10.1016/j.exer.2017.02.014_bib38 article-title: Optic disc hemorrhage may be associated with retinal nerve fiber loss in otherwise normal eyes publication-title: Ophthalmology doi: 10.1016/j.ophtha.2008.08.024 – volume: 10 start-page: 45 issue: 1 year: 2003 ident: 10.1016/j.exer.2017.02.014_bib88 article-title: Tumor necrosis factor signaling publication-title: Cell Death Differ. doi: 10.1038/sj.cdd.4401189 – volume: 20 start-page: 1040 issue: 9 year: 2006 ident: 10.1016/j.exer.2017.02.014_bib55 article-title: TNF-alpha promoter polymorphisms and primary open-angle glaucoma publication-title: Eye (Lond) doi: 10.1038/sj.eye.6702078 – volume: 703 start-page: 95 year: 2010 ident: 10.1016/j.exer.2017.02.014_bib66 article-title: A role for complement in glaucoma? publication-title: Adv. Exp. Med. Biol. doi: 10.1007/978-1-4419-5635-4_7 – volume: 23 start-page: 547 issue: 8 year: 2014 ident: 10.1016/j.exer.2017.02.014_bib37 article-title: Changes in retinal nerve fiber layer thickness after optic disc hemorrhage in glaucomatous eyes publication-title: J. Glaucoma doi: 10.1097/IJG.0000000000000083 – volume: 565 start-page: 39 year: 2014 ident: 10.1016/j.exer.2017.02.014_bib29 article-title: Astrocyte loss and astrogliosis in neuroinflammatory disorders publication-title: Neurosci. Lett. doi: 10.1016/j.neulet.2013.10.012 – volume: 61 start-page: 1218 issue: 8 year: 2013 ident: 10.1016/j.exer.2017.02.014_bib79 article-title: Reversible reactivity by optic nerve astrocytes publication-title: Glia doi: 10.1002/glia.22507 – volume: 15 start-page: 80 issue: 2 year: 2004 ident: 10.1016/j.exer.2017.02.014_bib84 article-title: The immune system and glaucoma publication-title: Curr. Opin. Ophthalmol. doi: 10.1097/00055735-200404000-00003 – volume: 11 start-page: 194 year: 2014 ident: 10.1016/j.exer.2017.02.014_bib53 article-title: Tumor necrosis factor alpha has an early protective effect on retinal ganglion cells after optic nerve crush publication-title: J. Neuroinflammation doi: 10.1186/s12974-014-0194-3 – volume: 1268 start-page: 127 year: 2012 ident: 10.1016/j.exer.2017.02.014_bib21 article-title: Aging and the neurovascular unit publication-title: Ann. N. Y. Acad. Sci. doi: 10.1111/j.1749-6632.2012.06686.x – volume: 134 start-page: 315 year: 2015 ident: 10.1016/j.exer.2017.02.014_bib96 article-title: Glaucoma genes and mechanisms publication-title: Prog. Mol. Biol. Transl. Sci. doi: 10.1016/bs.pmbts.2015.04.008 – volume: 9 start-page: e104416 issue: 9 year: 2014 ident: 10.1016/j.exer.2017.02.014_bib4 article-title: Oral microbiome link to neurodegeneration in glaucoma publication-title: PLoS One doi: 10.1371/journal.pone.0104416 – volume: 1 start-page: 105 issue: 2 year: 2012 ident: 10.1016/j.exer.2017.02.014_bib19 article-title: Predictive factors within the optic nerve complex for glaucoma progression: disc hemorrhage and parapapillary atrophy publication-title: Asia Pac J. Ophthalmol. (Phila) doi: 10.1097/APO.0b013e31824a65f8 – volume: 52 start-page: 8442 issue: 11 year: 2011 ident: 10.1016/j.exer.2017.02.014_bib101 article-title: Neurodegenerative and inflammatory pathway components linked to TNF-α/TNFR1 signaling in the glaucomatous human retina publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.11-8152 – volume: 4 issue: 8 year: 2014 ident: 10.1016/j.exer.2017.02.014_bib74 article-title: The complex role of neuroinflammation in glaucoma publication-title: Cold Spring Harb. Perspect. Med. doi: 10.1101/cshperspect.a017269 – volume: 19 start-page: 89 issue: 2 year: 2008 ident: 10.1016/j.exer.2017.02.014_bib86 article-title: Optic disc hemorrhages in glaucoma and ocular hypertension: implications and recommendations publication-title: Curr. Opin. Ophthalmol. doi: 10.1097/ICU.0b013e3282f3e6bc – volume: 131 start-page: 421 issue: 4 year: 2001 ident: 10.1016/j.exer.2017.02.014_bib100 article-title: T cell subsets and sIL-2R/IL-2 levels in patients with glaucoma publication-title: Am. J. Ophthalmol. doi: 10.1016/S0002-9394(00)00862-X – volume: 2 start-page: 78 issue: 2 year: 2009 ident: 10.1016/j.exer.2017.02.014_bib36 article-title: The two sides of cytokine signaling and glaucomatous optic neuropathy publication-title: J. Ocul. Biol. Dis. Infor doi: 10.1007/s12177-009-9026-6 – volume: 4 start-page: 1 issue: 1 year: 1992 ident: 10.1016/j.exer.2017.02.014_bib89 article-title: The role of cytokines in the pathogenesis of inflammatory eye disease publication-title: Cytokine doi: 10.1016/1043-4666(92)90028-P – volume: 18 start-page: 779 year: 2012 ident: 10.1016/j.exer.2017.02.014_bib92 article-title: Polymorphism in the TNF-α(-863) locus associated with reduced risk of primary open angle glaucoma publication-title: Mol. Vis. – volume: 173 start-page: 409 year: 2008 ident: 10.1016/j.exer.2017.02.014_bib83 article-title: TNF-alpha signaling in glaucomatous neurodegeneration publication-title: Prog. Brain Res. doi: 10.1016/S0079-6123(08)01128-X – volume: 60 start-page: 13 issue: 1 year: 2012 ident: 10.1016/j.exer.2017.02.014_bib18 article-title: Structural basis of glaucoma: the fortified astrocytes of the optic nerve head are the target of raised intraocular pressure publication-title: Glia doi: 10.1002/glia.21242 – volume: 173 start-page: 303 year: 2008 ident: 10.1016/j.exer.2017.02.014_bib30 article-title: Mouse genetic models: an ideal system for understanding glaucomatous neurodegeneration and neuroprotection publication-title: Prog. Brain Res. doi: 10.1016/S0079-6123(08)01122-9 – volume: 48 start-page: 3161 issue: 7 year: 2007 ident: 10.1016/j.exer.2017.02.014_bib40 article-title: Global changes in optic nerve head gene expression after exposure to elevated intraocular pressure in a rat glaucoma model publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.06-1282 – volume: 252 start-page: 761 issue: 5 year: 2014 ident: 10.1016/j.exer.2017.02.014_bib49 article-title: Minocycline upregulates pro-survival genes and downregulates pro-apoptotic genes in experimental glaucoma publication-title: Graefes Arch. Clin. Exp. Ophthalmol. doi: 10.1007/s00417-014-2588-4 – volume: 35 start-page: 153 year: 2012 ident: 10.1016/j.exer.2017.02.014_bib60 article-title: Under pressure: cellular and molecular responses during glaucoma, a common neurodegeneration with axonopathy publication-title: Annu. Rev. Neurosci. doi: 10.1146/annurev.neuro.051508.135728 – volume: 117 start-page: 1050 issue: 8 year: 1999 ident: 10.1016/j.exer.2017.02.014_bib58 article-title: Microglia in the optic nerve head and the region of parapapillary chorioretinal atrophy in glaucoma publication-title: Arch. Ophthalmol. doi: 10.1001/archopht.117.8.1050 – start-page: 1 year: 2015 ident: 10.1016/j.exer.2017.02.014_bib24 article-title: Evaluation of genetic polymorphisms in clusterin and tumor necrosis factor-alpha genes in south indian individuals with pseudoexfoliation syndrome publication-title: Curr. Eye Res. – volume: 8 start-page: 362 year: 2014 ident: 10.1016/j.exer.2017.02.014_bib17 article-title: The impact of microglial activation on blood-brain barrier in brain diseases publication-title: Front. Cell Neurosci. doi: 10.3389/fncel.2014.00362 – volume: 51 start-page: 5697 issue: 11 year: 2010 ident: 10.1016/j.exer.2017.02.014_bib51 article-title: Glaucomatous tissue stress and the regulation of immune response through glial Toll-like receptor signaling publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.10-5407 – volume: 16 start-page: 215 issue: 2 year: 2007 ident: 10.1016/j.exer.2017.02.014_bib28 article-title: Relationship between retinal glial cell activation in glaucoma and vascular dysregulation publication-title: J. Glaucoma doi: 10.1097/IJG.0b013e31802d045a – volume: 51 start-page: 5071 issue: 10 year: 2010 ident: 10.1016/j.exer.2017.02.014_bib85 article-title: Oxidative stress and the regulation of complement activation in human glaucoma publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.10-5289 – volume: 519 start-page: 599 issue: 4 year: 2011 ident: 10.1016/j.exer.2017.02.014_bib11 article-title: Early microglia activation in a mouse model of chronic glaucoma publication-title: J. Comp. Neurol. doi: 10.1002/cne.22516 – volume: 248 start-page: 1771 issue: 12 year: 2010 ident: 10.1016/j.exer.2017.02.014_bib44 article-title: Altered temporal peripapillary retinal flow in patients with disc hemorrhages publication-title: Graefes Arch. Clin. Exp. Ophthalmol. doi: 10.1007/s00417-010-1441-7 – volume: 10 start-page: 76 issue: 1 year: 2013 ident: 10.1016/j.exer.2017.02.014_bib33 article-title: Deficiency of complement component 5 ameliorates glaucoma in DBA/2J mice publication-title: J. Neuroinflammation doi: 10.1186/1742-2094-10-76 – volume: 23 start-page: S59 issue: 8 Suppl. 1 year: 2014 ident: 10.1016/j.exer.2017.02.014_bib42 article-title: Immune phenomena in glaucoma and conformational disorders: why is the second eye not involved? publication-title: J. Glaucoma doi: 10.1097/IJG.0000000000000115 – volume: 36 start-page: 442 issue: 5 year: 2011 ident: 10.1016/j.exer.2017.02.014_bib82 article-title: Morphological changes of trabeculectomy specimens in different kinds of uveitic glaucoma publication-title: Curr. Eye Res. doi: 10.3109/02713683.2011.566409 – volume: 154 issue: 5 year: 2012 ident: 10.1016/j.exer.2017.02.014_bib80 article-title: Association of Toll-like receptor 4 gene polymorphisms in Japanese subjects with primary open-angle, normal-tension, and exfoliation glaucoma publication-title: Am. J. Ophthalmol. doi: 10.1016/j.ajo.2012.03.050 – volume: 47 start-page: 1024 issue: 3 year: 2006 ident: 10.1016/j.exer.2017.02.014_bib75 article-title: Complement component 1Q (C1Q) upregulation in retina of murine, primate, and human glaucomatous eyes publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.05-0830 – volume: 4 start-page: 3 issue: 1 year: 2011 ident: 10.1016/j.exer.2017.02.014_bib7 article-title: Inflammatory glaucoma publication-title: Oman J. Ophthalmol. doi: 10.4103/0974-620X.77655 – volume: 112 start-page: 10509 issue: 33 year: 2015 ident: 10.1016/j.exer.2017.02.014_bib54 article-title: Astrocytes phagocytose focal dystrophies from shortening myelin segments in the optic nerve of Xenopus laevis at metamorphosis publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.1506486112 – volume: 61 start-page: 186 issue: 2 year: 1983 ident: 10.1016/j.exer.2017.02.014_bib2 article-title: Visual field and retinal nerve fibre layer in early glaucoma after optic disc haemorrhage publication-title: Acta Ophthalmol. (Copenh) doi: 10.1111/j.1755-3768.1983.tb01412.x – volume: 132 start-page: 411 issue: 3 year: 2001 ident: 10.1016/j.exer.2017.02.014_bib45 article-title: Optic disk characteristics before the occurrence of disk hemorrhage in glaucoma patients publication-title: Am. J. Ophthalmol. doi: 10.1016/S0002-9394(01)01009-1 – volume: 1207 start-page: 46 year: 2010 ident: 10.1016/j.exer.2017.02.014_bib20 article-title: The neurovascular unit, matrix proteases, and innate inflammation publication-title: Ann. N. Y. Acad. Sci. doi: 10.1111/j.1749-6632.2010.05760.x – volume: 19 start-page: 526 year: 2013 ident: 10.1016/j.exer.2017.02.014_bib98 article-title: Roles of tumor necrosis factor alpha gene polymorphisms, tumor necrosis factor alpha level in aqueous humor, and the risks of open angle glaucoma: a meta-analysis publication-title: Mol. Vis. – volume: 28 start-page: 348 issue: 5 year: 2009 ident: 10.1016/j.exer.2017.02.014_bib99 article-title: Para-inflammation in the aging retina publication-title: Prog. Retin Eye Res. doi: 10.1016/j.preteyeres.2009.06.001 – volume: 142 start-page: 49 year: 2015 ident: 10.1016/j.exer.2017.02.014_bib69 article-title: The role of astrocytes in optic nerve head fibrosis in glaucoma publication-title: Exp. Eye Res. doi: 10.1016/j.exer.2015.08.014 – volume: 121 start-page: 1429 issue: 4 year: 2011 ident: 10.1016/j.exer.2017.02.014_bib31 article-title: Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma publication-title: J. Clin. Invest doi: 10.1172/JCI44646 – volume: 54 start-page: 909 issue: 2 year: 2013 ident: 10.1016/j.exer.2017.02.014_bib52 article-title: Morphology of astrocytes in a glaucomatous optic nerve publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.12-10109 – volume: 7 start-page: e40065 issue: 7 year: 2012 ident: 10.1016/j.exer.2017.02.014_bib67 article-title: Etanercept, a widely used inhibitor of tumor necrosis factor-α (TNF-α), prevents retinal ganglion cell loss in a rat model of glaucoma publication-title: PLoS One doi: 10.1371/journal.pone.0040065 – volume: 31 start-page: 386 issue: 7 year: 2015 ident: 10.1016/j.exer.2017.02.014_bib91 article-title: The function of matricellular proteins in the lamina cribrosa and trabecular meshwork in glaucoma publication-title: J. Ocul. Pharmacol. Ther. doi: 10.1089/jop.2014.0163 – volume: 2 start-page: 24 year: 2009 ident: 10.1016/j.exer.2017.02.014_bib61 article-title: Network analysis of human glaucomatous optic nerve head astrocytes publication-title: BMC Med. Genomics doi: 10.1186/1755-8794-2-24 – volume: 108 start-page: 1176 issue: 3 year: 2011 ident: 10.1016/j.exer.2017.02.014_bib59 article-title: Myelination transition zone astrocytes are constitutively phagocytic and have synuclein dependent reactivity in glaucoma publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.1013965108 – volume: 249 start-page: 849 issue: 6 year: 2011 ident: 10.1016/j.exer.2017.02.014_bib47 article-title: Similarities and differences between primary and secondary degeneration of the optic nerve and the effect of minocycline publication-title: Graefes Arch. Clin. Exp. Ophthalmol. doi: 10.1007/s00417-010-1608-2 – volume: 49 start-page: 1437 issue: 4 year: 2008 ident: 10.1016/j.exer.2017.02.014_bib9 article-title: Reduced retina microglial activation and improved optic nerve integrity with minocycline treatment in the DBA/2J mouse model of glaucoma publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.07-1337 – volume: 56 start-page: 4447 issue: 8 year: 2015 ident: 10.1016/j.exer.2017.02.014_bib65 article-title: Dexamethasone stiffens trabecular meshwork, trabecular meshwork cells, and matrix publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.15-16739 – volume: 91 start-page: 554 issue: 5 year: 2010 ident: 10.1016/j.exer.2017.02.014_bib5 article-title: Neuroprotection in glaucoma - is there a future role? publication-title: Exp. Eye Res. doi: 10.1016/j.exer.2010.08.009 – volume: 99 start-page: e52731 year: 2015 ident: 10.1016/j.exer.2017.02.014_bib10 article-title: In vivo dynamics of retinal microglial activation during neurodegeneration: confocal ophthalmoscopic imaging and cell morphometry in mouse glaucoma publication-title: J. Vis. Exp. – volume: 31 start-page: 377 issue: 5 year: 2012 ident: 10.1016/j.exer.2017.02.014_bib43 article-title: Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease publication-title: Prog. Retin Eye Res. doi: 10.1016/j.preteyeres.2012.04.004 – volume: 124 start-page: 520 issue: 4 year: 2006 ident: 10.1016/j.exer.2017.02.014_bib46 article-title: Minocycline delays death of retinal ganglion cells in experimental glaucoma and after optic nerve transection publication-title: Arch. Ophthalmol. doi: 10.1001/archopht.124.4.520 – volume: 55 start-page: 2491 issue: 4 year: 2014 ident: 10.1016/j.exer.2017.02.014_bib22 article-title: Clusterin and complement activation in exfoliation glaucoma publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.13-12941 – volume: 64 start-page: 523 issue: 5 year: 2001 ident: 10.1016/j.exer.2017.02.014_bib103 article-title: Activated microglia in the human glaucomatous optic nerve head publication-title: J. Neurosci. Res. doi: 10.1002/jnr.1104 – volume: 8 start-page: e67094 issue: 6 year: 2013 ident: 10.1016/j.exer.2017.02.014_bib64 article-title: The time course of gene expression during reactive gliosis in the optic nerve publication-title: PLoS One doi: 10.1371/journal.pone.0067094 – volume: 8 start-page: e71808 issue: 8 year: 2013 ident: 10.1016/j.exer.2017.02.014_bib35 article-title: VEGF receptor blockade markedly reduces retinal microglia/macrophage infiltration into laser-induced CNV publication-title: PLoS One doi: 10.1371/journal.pone.0071808 – volume: 39 start-page: 105 issue: 2 year: 2014 ident: 10.1016/j.exer.2017.02.014_bib41 article-title: From mechanosensitivity to inflammatory responses: new players in the pathology of glaucoma publication-title: Curr. Eye Res. doi: 10.3109/02713683.2013.836541 – volume: 7 start-page: 189 year: 2015 ident: 10.1016/j.exer.2017.02.014_bib94 article-title: Ageing, neuroinflammation and neurodegeneration publication-title: Front. Biosci. Sch. Ed. doi: 10.2741/s433 – volume: 55 start-page: 4922 issue: 8 year: 2014 ident: 10.1016/j.exer.2017.02.014_bib62 article-title: Ultrastructural changes associated with dexamethasone-induced ocular hypertension in mice publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.14-14429 – volume: 353 start-page: 339 issue: 2 year: 2013 ident: 10.1016/j.exer.2017.02.014_bib70 article-title: The role of Müller glia and microglia in glaucoma publication-title: Cell Tissue Res. doi: 10.1007/s00441-013-1666-y – volume: 32 start-page: 42 issue: 1 year: 2000 ident: 10.1016/j.exer.2017.02.014_bib102 article-title: Tumor necrosis factor-alpha: a potentially neurodestructive cytokine produced by glia in the human glaucomatous optic nerve head publication-title: Glia doi: 10.1002/1098-1136(200010)32:1<42::AID-GLIA40>3.0.CO;2-3 – volume: 60 start-page: 255 issue: 4 year: 2012 ident: 10.1016/j.exer.2017.02.014_bib1 article-title: Glaucomatous neurodegeneration: an eye on tumor necrosis factor-alpha publication-title: Indian J. Ophthalmol. doi: 10.4103/0301-4738.98700 – volume: 49 start-page: 4453 issue: 10 year: 2008 ident: 10.1016/j.exer.2017.02.014_bib71 article-title: Association of Toll-like receptor 4 gene polymorphisms with normal tension glaucoma publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.07-1575 – start-page: 1 year: 2017 ident: 10.1016/j.exer.2017.02.014_bib104 article-title: Astrocytes and glaucomatous neurodegeneration publication-title: Exper. Eye Res. doi: 10.1016/j.exer.2017.02.013 – volume: 35 start-page: 12088 issue: 35 year: 2015 ident: 10.1016/j.exer.2017.02.014_bib16 article-title: Soluble tumor necrosis factor alpha promotes retinal ganglion cell death in glaucoma via calcium-permeable AMPA receptor activation publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.1273-15.2015 – volume: 36 start-page: 478 issue: 2 year: 1995 ident: 10.1016/j.exer.2017.02.014_bib15 article-title: Dexamethasone-induced ocular hypertension in perfusion-cultured human eyes publication-title: Invest Ophthalmol. Vis. Sci. – volume: 86 start-page: 811 issue: 12 year: 2006 ident: 10.1016/j.exer.2017.02.014_bib93 article-title: The prevalence of disc hemorrhage and papillary atrophy in Beijing Eye Study publication-title: Zhonghua Yi Xue Za Zhi – volume: 29 start-page: 93 year: 2014 ident: 10.1016/j.exer.2017.02.014_bib77 article-title: Human CNS immune senescence and neurodegeneration publication-title: Curr. Opin. Immunol. doi: 10.1016/j.coi.2014.05.005 – volume: 68 start-page: 29 issue: 1 year: 1999 ident: 10.1016/j.exer.2017.02.014_bib63 article-title: Enhanced tenascin expression associated with reactive astrocytes in human optic nerve heads with primary open angle glaucoma publication-title: Exp. Eye Res. doi: 10.1006/exer.1998.0577 – volume: 37 start-page: 174 year: 2014 ident: 10.1016/j.exer.2017.02.014_bib90 article-title: The role of matricellular proteins in glaucoma publication-title: Matrix Biol. doi: 10.1016/j.matbio.2014.03.007 – volume: 52 start-page: 504 issue: 1 year: 2011 ident: 10.1016/j.exer.2017.02.014_bib39 article-title: Cell proliferation and interleukin-6-type cytokine signaling are implicated by gene expression responses in early optic nerve head injury in rat glaucoma publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.10-5317 – volume: 71 start-page: 44 year: 2014 ident: 10.1016/j.exer.2017.02.014_bib32 article-title: Combinatorial targeting of early pathways profoundly inhibits neurodegeneration in a mouse model of glaucoma publication-title: Neurobiol. Dis. doi: 10.1016/j.nbd.2014.07.016 – volume: 40 issue: 4 year: 2012 ident: 10.1016/j.exer.2017.02.014_bib12 article-title: Association of tumour necrosis factor-alpha -308 G/A polymorphism with primary open-angle glaucoma publication-title: Clin. Exp. Ophthalmol. doi: 10.1111/j.1442-9071.2011.02595.x – volume: 126 start-page: 1567 issue: 8 year: 2013 ident: 10.1016/j.exer.2017.02.014_bib13 article-title: Neuroprotection in glaucoma: present and future publication-title: Chin. Med. J. Engl. doi: 10.3760/cma.j.issn.0366-6999.20123565 – volume: 17 start-page: 31 issue: 1 year: 2003 ident: 10.1016/j.exer.2017.02.014_bib50 article-title: Association of tumour necrosis factor alpha -308 gene polymorphism with primary open-angle glaucoma in Chinese publication-title: Eye (Lond) doi: 10.1038/sj.eye.6700227 – volume: 33 start-page: 331 issue: 5 year: 1989 ident: 10.1016/j.exer.2017.02.014_bib23 article-title: Disc hemorrhages in the glaucomas publication-title: Surv. Ophthalmol. doi: 10.1016/0039-6257(89)90010-6 – volume: 491 start-page: 394 issue: 2 year: 1989 ident: 10.1016/j.exer.2017.02.014_bib68 article-title: Production of tumor necrosis factor-alpha by microglia and astrocytes in culture publication-title: Brain Res. doi: 10.1016/0006-8993(89)90078-4 – volume: 1 start-page: 23 year: 2010 ident: 10.1016/j.exer.2017.02.014_bib25 article-title: Early involvement of immune/inflammatory response genes in retinal degeneration in DBA/2J mice publication-title: Ophthalmol. Eye Dis. – volume: 11 start-page: 1384 issue: 2 year: 2015 ident: 10.1016/j.exer.2017.02.014_bib81 article-title: Potential regulatory molecules in the human trabecular meshwork of patients with glaucoma: immunohistochemical profile of a number of inflammatory cytokines publication-title: Mol. Med. Rep. doi: 10.3892/mmr.2014.2772 – volume: 122 start-page: 1246 issue: 4 year: 2012 ident: 10.1016/j.exer.2017.02.014_bib34 article-title: Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma publication-title: J. Clin. Invest doi: 10.1172/JCI61135 – start-page: e43602 year: 2012 ident: 10.1016/j.exer.2017.02.014_bib8 article-title: Early reduction of microglia activation by irradiation in a model of chronic glaucoma publication-title: PLoS One. U. S. doi: 10.1371/journal.pone.0043602 – start-page: 1 year: 2015 ident: 10.1016/j.exer.2017.02.014_bib6 article-title: The pathogenesis of raised intraocular pressure in uveitis publication-title: Curr. Eye Res. – reference: 22580107 - Prog Retin Eye Res. 2012 Sep;31(5):377-406 – reference: 17473733 - J Glaucoma. 2007 Mar;16(2):215-9 – reference: 23779255 - Cell Tissue Res. 2013 Aug;353(2):339-45 – reference: 24908174 - Curr Opin Immunol. 2014 Aug;29:93-6 – reference: 23826199 - PLoS One. 2013 Jun 27;8(6):e67094 – reference: 26310163 - Prog Mol Biol Transl Sci. 2015;134:315-42 – reference: 19041474 - Ophthalmology. 2008 Dec;115(12):2132-40 – reference: 19672464 - J Ocul Biol Dis Infor. 2009 Jun;2(2):78-83 – reference: 21575121 - Clin Exp Ophthalmol. 2012 May-Jun;40(4):e156-62 – reference: 24128880 - Neurosci Lett. 2014 Apr 17;565:39-41 – reference: 25992962 - J Vis Exp. 2015 May 11;(99):e52731 – reference: 17396692 - Ophthalmic Surg Lasers Imaging. 2007 Mar-Apr;38(2):118-25 – reference: 11530060 - Am J Ophthalmol. 2001 Sep;132(3):411-3 – reference: 19233171 - Exp Eye Res. 2009 Apr;88(4):825-30 – reference: 17151265 - J Neurosci. 2006 Dec 6;26(49):12633-41 – reference: 21713239 - Oman J Ophthalmol. 2011 Jan;4(1):3-9 – reference: 26374513 - Acta Neuropathol Commun. 2015 Sep 15;3:56 – reference: 9986739 - Exp Eye Res. 1999 Jan;68(1):29-40 – reference: 10975909 - Glia. 2000 Oct;32(1):42-50 – reference: 6880632 - Acta Ophthalmol (Copenh). 1983 Apr;61(2):186-94 – reference: 21917936 - Invest Ophthalmol Vis Sci. 2011 Oct 31;52(11):8442-54 – reference: 25275909 - J Glaucoma. 2014 Oct-Nov;23(8 Suppl 1):S59-61 – reference: 23217584 - Surv Ophthalmol. 2013 Jan-Feb;58(1):1-10 – reference: 26107132 - Asia Pac J Ophthalmol (Phila). 2012 Mar-Apr;1(2):105-12 – reference: 12579167 - Eye (Lond). 2003 Jan;17(1):31-4 – reference: 19560552 - Prog Retin Eye Res. 2009 Sep;28(5):348-68 – reference: 24566901 - Graefes Arch Clin Exp Ophthalmol. 2014 May;252(5):761-72 – reference: 24993677 - Cold Spring Harb Perspect Med. 2014 Jul 03;4(8):null – reference: 20352036 - Ophthalmol Eye Dis. 2010 Mar 11;1:23-41 – reference: 23650091 - Glia. 2013 Aug;61(8):1218-35 – reference: 25849827 - Curr Eye Res. 2015;40(12):1218-24 – reference: 21199938 - Proc Natl Acad Sci U S A. 2011 Jan 18;108(3):1176-81 – reference: 23768921 - Surv Ophthalmol. 2013 Jul-Aug;58(4):311-20 – reference: 22831837 - Am J Ophthalmol. 2012 Nov;154(5):825-832.e1 – reference: 18385061 - Invest Ophthalmol Vis Sci. 2008 Apr;49(4):1437-46 – reference: 1617154 - Cytokine. 1992 Jan;4(1):1-5 – reference: 22952717 - PLoS One. 2012;7(8):e43602 – reference: 18929124 - Prog Brain Res. 2008;173:409-21 – reference: 2765895 - Brain Res. 1989 Jul 10;491(2):394-7 – reference: 12202516 - Invest Ophthalmol Vis Sci. 2002 Sep;43(9):2962-8 – reference: 25848892 - J Ocul Pharmacol Ther. 2015 Sep;31(7):386-95 – reference: 20955425 - Ann N Y Acad Sci. 2010 Oct;1207:46-9 – reference: 24550356 - Invest Ophthalmol Vis Sci. 2014 Apr 17;55(4):2491-9 – reference: 12655295 - Cell Death Differ. 2003 Jan;10(1):45-65 – reference: 9075084 - J Glaucoma. 1997 Feb;6(1):62-4 – reference: 7843916 - Invest Ophthalmol Vis Sci. 1995 Feb;36(2):478-89 – reference: 16606878 - Arch Ophthalmol. 2006 Apr;124(4):520-6 – reference: 21501078 - Curr Eye Res. 2011 May;36(5):442-8 – reference: 25180891 - PLoS One. 2014 Sep 02;9(9):e104416 – reference: 25132557 - Neurobiol Dis. 2014 Nov;71:44-52 – reference: 24144321 - Curr Eye Res. 2014 Feb;39(2):105-19 – reference: 24410139 - Int J Neurosci. 2014 Oct;124(10):755-61 – reference: 23806181 - J Neuroinflammation. 2013 Jun 27;10:76 – reference: 16051195 - Brain Res. 2005 Aug 16;1053(1-2):185-94 – reference: 22824592 - Indian J Ophthalmol. 2012 Jul;60(4):255-61 – reference: 18301280 - Curr Opin Ophthalmol. 2008 Mar;19(2):89-94 – reference: 25961695 - Front Biosci (Schol Ed). 2015 Jun 01;7:189-204 – reference: 10448748 - Arch Ophthalmol. 1999 Aug;117(8):1050-6 – reference: 20635187 - Graefes Arch Clin Exp Ophthalmol. 2010 Dec;248(12):1771-5 – reference: 24727033 - Matrix Biol. 2014 Jul;37:174-82 – reference: 23977149 - PLoS One. 2013 Aug 20;8(8):e71808 – reference: 22509108 - Mol Vis. 2012;18:779-85 – reference: 20538986 - Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5697-707 – reference: 22802951 - PLoS One. 2012;7(7):e40065 – reference: 18083105 - Cell. 2007 Dec 14;131(6):1164-78 – reference: 20484586 - Invest Ophthalmol Vis Sci. 2010 Oct;51(10):5071-82 – reference: 18586872 - Invest Ophthalmol Vis Sci. 2008 Oct;49(10):4453-7 – reference: 26193921 - Invest Ophthalmol Vis Sci. 2015 Jul;56(8):4447-59 – reference: 20711709 - Adv Exp Med Biol. 2010;703:95-104 – reference: 21383504 - J Clin Invest. 2011 Apr;121(4):1429-44 – reference: 16138112 - Eye (Lond). 2006 Sep;20(9):1040-3 – reference: 25407441 - J Neuroinflammation. 2014 Nov 19;11:194 – reference: 26338321 - J Neurosci. 2015 Sep 2;35(35):12088-102 – reference: 24923557 - PLoS One. 2014 Jun 12;9(6):e99719 – reference: 21246546 - J Comp Neurol. 2011 Mar 1;519(4):599-620 – reference: 16505037 - Invest Ophthalmol Vis Sci. 2006 Mar;47(3):1024-9 – reference: 25404894 - Front Cell Neurosci. 2014 Nov 03;8:362 – reference: 23595396 - Chin Med J (Engl). 2013;126(8):1567-77 – reference: 17591886 - Invest Ophthalmol Vis Sci. 2007 Jul;48(7):3161-77 – reference: 15021215 - Curr Opin Ophthalmol. 2004 Apr;15(2):80-4 – reference: 11292402 - Am J Ophthalmol. 2001 Apr;131(4):421-6 – reference: 20800593 - Exp Eye Res. 2010 Nov;91(5):554-66 – reference: 18929118 - Prog Brain Res. 2008;173:303-21 – reference: 23559847 - Mol Vis. 2013;19:526-35 – reference: 25028360 - Invest Ophthalmol Vis Sci. 2014 Jul 15;55(8):4922-33 – reference: 25811482 - PLoS One. 2015 Mar 26;10(3):e0122184 – reference: 21948238 - Glia. 2012 Jan;60(1):13-28 – reference: 26321510 - Exp Eye Res. 2016 Jan;142:49-55 – reference: 21229256 - Graefes Arch Clin Exp Ophthalmol. 2011 Jun;249(6):849-57 – reference: 20847120 - Invest Ophthalmol Vis Sci. 2011 Jan 25;52(1):504-18 – reference: 25351602 - Mol Med Rep. 2015 Feb;11(2):1384-90 – reference: 11391707 - J Neurosci Res. 2001 Jun 1;64(5):523-32 – reference: 25093520 - J Glaucoma. 2014 Oct-Nov;23(8):547-52 – reference: 16681968 - Zhonghua Yi Xue Za Zhi. 2006 Mar 28;86(12):811-4 – reference: 22994231 - Ann N Y Acad Sci. 2012 Sep;1268:127-33 – reference: 26240339 - Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10509-14 – reference: 2655138 - Surv Ophthalmol. 1989 Mar-Apr;33(5):331-7 – reference: 19426536 - BMC Med Genomics. 2009 May 09;2:24 – reference: 23322566 - Invest Ophthalmol Vis Sci. 2013 Feb 01;54(2):909-17 – reference: 23608634 - Eur Cytokine Netw. 2013 Mar;24(1):27-36 – reference: 22426214 - J Clin Invest. 2012 Apr;122(4):1246-61 – reference: 22524788 - Annu Rev Neurosci. 2012;35:153-79 |
| SSID | ssj0003474 |
| Score | 2.5856397 |
| SecondaryResourceType | review_article |
| Snippet | Mounting evidence suggests neuroinflammation is a key process in glaucoma, yet the precise roles are not known. Understanding these complex processes, which... |
| SourceID | pubmedcentral proquest pubmed crossref elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 20 |
| SubjectTerms | Animals Astrocyte Astrocytes - pathology Glaucoma Glaucoma - physiopathology Humans Inflammation Inflammation - physiopathology Lasker Microglia Monocyte Neurodegeneration Optic Nerve - immunology Optic Neuritis - physiopathology Retinal Ganglion Cells - immunology |
| Title | Neuroinflammation in glaucoma: A new opportunity |
| URI | https://dx.doi.org/10.1016/j.exer.2017.02.014 https://www.ncbi.nlm.nih.gov/pubmed/28242160 https://www.proquest.com/docview/1872884242 https://pubmed.ncbi.nlm.nih.gov/PMC5497582 |
| Volume | 157 |
| WOSCitedRecordID | wos000401305600004&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals 2021 customDbUrl: eissn: 1096-0007 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0003474 issn: 0014-4835 databaseCode: AIEXJ dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1baxNBFB40FfFFtPUSL2UF8UVWdmdnsrO-xVKtQkofKgRElpnZ2SbBTkKTSPvvPWdn9tIEiwq-LCHZW-Y7e277nXMIeS2lpFzHKlScsZAZA3pQqCJE216mYBMVc8Mm0uNjMR5nJ55uu6zGCaTWisvLbPFfoYbvAGwsnf0LuJuTwhfwGUCHLcAO2z8Cvmq3AScCqF1ZIqY0wElew8WkK0S3WKyyQM97bXEqAP8Q14PGZw01r238b65wtkon7bWRp0GOb5sTHUGoPAlBgJaYZT_z4tYUBB3Nax72JxywO_GMRZ94AGPW8lW8Mo0Z5iLdS2nj9GeEnObIDbJtFKxrQV2ryKhjbF1fgC017jIKs3c4dgrpd2nVV9VVm3YgXJxXGELUyGg8iFqT1hANT0YHEABDTARWeoemPBM9sjP8fDj-0pjrhPlW3f7f-MoqRwLcvAHsHe2v9jtHZjtQ2eTbdhyY0wfkvo88gqGTmIfklrG7ZG9o5Wp-fhW8CSoucPWSZZfcHXnKxR5JtuQpmNqglqf3wTAAaQo60vQt_v6IfP14eHpwFPpJG6FmnK9CGktjwNkr4yIykg6kUPCc0oHh8PBqozTSdouMJUUmNKOGRQUttWCcqbjUPE0ek56dW_OUBFRKwxOpdAqOqipLxTOlooFkGBmwkvZJXC9brn0bepyG8iOv-YazHFc9x1XPI5rDqvfJ2-aYhWvCcuPevEYj926kcw9zEK8bj3tVQ5eDjsUXZ9Ka-XqZxyKlQjDAvU-eOCib-6jFoU_SayA3O2D_9uu_2Omk6uPuJfPZPx_5nNxrH8wXpLe6WJuX5I7-uZouL_bJ7XQs9r24_wIJIr-X |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Neuroinflammation+in+glaucoma%3A+A+new+opportunity%5B1%5D&rft.jtitle=Experimental+eye+research&rft.au=Williams%2C+Pete+A&rft.au=Marsh-Armstrong%2C+Nick&rft.au=Howell%2C+Gareth+R&rft.date=2017-04-01&rft.issn=0014-4835&rft.eissn=1096-0007&rft.volume=157&rft.spage=20&rft.epage=27&rft_id=info:doi/10.1016%2Fj.exer.2017.02.014&rft_id=info%3Apmid%2F28242160&rft.externalDocID=PMC5497582 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0014-4835&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0014-4835&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0014-4835&client=summon |