Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population

Mice and humans with growth hormone receptor/IGF-1 deficiencies display major reductions in age-related diseases. Because protein restriction reduces GHR-IGF-1 activity, we examined links between protein intake and mortality. Respondents aged 50-65 reporting high protein intake had a 75% increase in...

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Veröffentlicht in:	Cell metabolism Jg. 19; H. 3; S. 407
Hauptverfasser:	Levine, Morgan E, Suarez, Jorge A, Brandhorst, Sebastian, Balasubramanian, Priya, Cheng, Chia-Wei, Madia, Federica, Fontana, Luigi, Mirisola, Mario G, Guevara-Aguirre, Jaime, Wan, Junxiang, Passarino, Giuseppe, Kennedy, Brian K, Wei, Min, Cohen, Pinchas, Crimmins, Eileen M, Longo, Valter D
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 04.03.2014
Schlagworte:	Aged Animals Breast Neoplasms - etiology Carrier Proteins - genetics Carrier Proteins - metabolism Cross-Sectional Studies Diabetes Mellitus - mortality Diet, Protein-Restricted Female Follow-Up Studies Humans Insulin-Like Growth Factor I - metabolism Longevity Male Melanoma - etiology Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Middle Aged Neoplasms - diet therapy Neoplasms - epidemiology Neoplasms - mortality Proportional Hazards Models Signal Transduction
ISSN:	1932-7420, 1932-7420
Online-Zugang:	Weitere Angaben
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