Gli signaling pathway modulates fibroblast activation and facilitates scar formation in pulmonary fibrosis

Pulmonary fibrosis is characterized by progressive and irreversible scarring of alveoli, which causes reduction of surface epithelial area and eventually respiratory failure. The precise mechanism of alveolar scarring is poorly understood. In this study, we explored transcriptional signatures of act...

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Vydáno v:	Biochemical and biophysical research communications Ročník 514; číslo 3; s. 684 - 690
Hlavní autoři:	Tsukui, Tatsuya, Ueha, Satoshi, Shichino, Shigeyuki, Hashimoto, Shinichi, Nakajima, Takuya, Shiraishi, Kazushige, Kihara, Miho, Kiyonari, Hiroshi, Inagaki, Yutaka, Matsushima, Kouji
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Elsevier Inc 30.06.2019
Témata:	epithelium extracellular matrix Fibroblasts fibrosis GANT61 gene expression regulation Gli pathway lungs metabolism mice oncogenes Pulmonary fibrosis Scar signal transduction transcription (genetics) transcription factors translation (genetics) Wound healing BLM Wound healing Gli Scar ECM α-SMA mKO1 Pulmonary fibrosis Col-GFP Fibroblasts Gli pathway GANT61 IPF
ISSN:	0006-291X, 1090-2104, 1090-2104
On-line přístup:	Získat plný text
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