Withaferin A inhibits breast cancer invasion and metastasis at sub‐cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation

Withaferin A (WFA) is purified from the plant Withania somnifera and inhibits the vimentin cytoskeleton. Vimentin overexpression in cancer correlates with metastatic disease, induction of epithelial to mesenchymal transition and reduced patient survival. As vimentin functions in cell motility, we wa...

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Vydané v:	International journal of cancer Ročník 129; číslo 11; s. 2744 - 2755
Hlavní autori:	Thaiparambil, Jose T., Bender, Laura, Ganesh, Thota, Kline, Erik, Patel, Pritty, Liu, Yuan, Tighiouart, Mourad, Vertino, Paula M., Harvey, R. Donald, Garcia, Anapatricia, Marcus, Adam I.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.12.2011 Wiley-Blackwell
Predmet:	Animals Antineoplastic Agents - therapeutic use Biological and medical sciences Blotting, Western breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Differentiation - drug effects Cell Line, Tumor Cell Movement - drug effects Female Gynecology. Andrology. Obstetrics Humans Liver Neoplasms - drug therapy Liver Neoplasms - metabolism Liver Neoplasms - secondary Lung Neoplasms - drug therapy Lung Neoplasms - metabolism Lung Neoplasms - secondary Mammary gland diseases Medical sciences metastasis Mice Mice, Inbred BALB C motility Neoplasm Invasiveness Phosphorylation - drug effects Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Serine - chemistry Tumors vimentin Vimentin - metabolism Withaferin A Withanolides - therapeutic use Vimentin Withaferin A Phosphorylation Breast disease Serine Cytotoxicity Breast cancer Malignant tumor Invasion Mammary gland diseases Cancerology metastasis Aminoacid Breast metastasis motility Inhibitor Dose Cancer
ISSN:	0020-7136, 1097-0215, 1097-0215
On-line prístup:	Získať plný text
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