Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers

The density of striatal dopamine D2 receptors has been shown to vary considerably among healthy subjects. 1 This variability might be due to genetic or environmental factors. In the present analysis we searched for relationships between dopamine D2 receptor gene (DRD2) polymorphisms and striatal dop...

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Vydané v:Molecular psychiatry Ročník 4; číslo 3; s. 290 - 296
Hlavní autori: Jönsson, E G, Nöthen, M M, Grünhage, F, Farde, L, Nakashima, Y, Propping, P, Sedvall, G C
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: London Nature Publishing Group UK 01.05.1999
Nature Publishing Group
Predmet:
Adult
Aged
Aged, 80 and over
Alleles
Behavioral Sciences
Biological and medical sciences
Biological Psychology
Carbon Radioisotopes - pharmacokinetics
Cell receptors
Cell structures and functions
Corpus Striatum - diagnostic imaging
Corpus Striatum - metabolism
Dopamine
Dopamine Antagonists - pharmacokinetics
Dopamine D2 receptors
Environmental factors
Female
Fundamental and applied biological sciences. Psychology
Gene polymorphism
Genotype
Humans
Introns
Linkage Disequilibrium
Male
Medicine
Medicine & Public Health
Middle Aged
Molecular and cellular biology
Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine)
Neostriatum
Neurosciences
original-research-article
Pharmacotherapy
Polymorphism, Genetic
Positron emission tomography
Promoter Regions, Genetic
Psychiatry
Raclopride
Receptor density
Receptors, Dopamine - analysis
Receptors, Dopamine - metabolism
Receptors, Dopamine D2 - genetics
Reference Values
Salicylamides - pharmacokinetics
Sex Characteristics
Tomography, Emission-Computed
receptor binding
association
[
DRD2
polymorphisms
PET
C]raclopride
Human
Biological fixation
D2 Dopamine receptor
Gene
Central nervous system
Corpus striatum
Density
Brain (vertebrata)
Polymorphism
ISSN:1359-4184, 1476-5578
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Shrnutí:The density of striatal dopamine D2 receptors has been shown to vary considerably among healthy subjects. 1 This variability might be due to genetic or environmental factors. In the present analysis we searched for relationships between dopamine D2 receptor gene (DRD2) polymorphisms and striatal dopamine D2 receptor density in vivo , as measured by positron emission tomography and [ 11 C]raclopride in 56 healthy subjects. There was a significant association between presence of a putative functional DRD2 promoter allele (−141C Del) and high striatal dopamine receptor density ( t  = 2.32, P  = 0.02). In agreement with some previous studies 2–4 the presence of the DRD2 TaqIA1 allele was associated with measures of low dopamine receptor density ( t  = 2.58, P  = 0.01). Also the DRD2 TaqIB1 allele was associated with low dopamine receptor density ( t  = 2.58, P  = 0.01) wheras there was no significant relationship between another common silent intronic DRD2 short tandem repeat polymorphism (STRP) and striatal dopamine D2 receptor density. The results suggest that DRD2 genotypes may participate differentially in the regulation of striatal dopamine D2 receptor density in healthy human subjects. The results should be interpreted with caution because of the limited sample size.
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SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1359-4184
1476-5578
DOI:10.1038/sj.mp.4000532