Study of short polystyrene monolith-fritted micro-liquid chromatography columns for analysis of neutral and basic compounds

This study details the effects of poly(styrene-divinylbenzene) (PS-DVB) frits in micro-HPLC columns for the separation of neutral and basic compounds. The procedure comprised the optimization of separations with only monolith or conventional fritted columns followed by method transference to short m...

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Vydáno v:Journal of Chromatography A Ročník 1042; číslo 1; s. 61 - 68
Hlavní autoři: Legido-Quigley, C, Smith, N.W
Médium: Journal Article
Jazyk:angličtina
Vydáno: Amsterdam Elsevier B.V 09.07.2004
Elsevier
Témata:
Analysis
Analytical biochemistry: general aspects, technics, instrumentation
Analytical chemistry
Analytical, structural and metabolic biochemistry
Basic compounds
Biological and medical sciences
Chemistry
Chromatographic methods and physical methods associated with chromatography
Chromatography, High Pressure Liquid
Ethylamines - chemistry
Exact sciences and technology
Fundamental and applied biological sciences. Psychology
General pharmacology
Hydrogen-Ion Concentration
Medical sciences
Monoliths
Pharmaceutical Preparations - analysis
Pharmacology. Drug treatments
Polystyrenes - chemistry
Solvents
Spectrophotometry, Ultraviolet
Stationary phases, LC
Monoliths
Basic compounds
Stationary phases, LC
LC; Basic compounds
Basic compound
Analysis
Styrene polymer
Monoliths; Stationary phases
Liquid chromatography
Column chromatography
Stationary phase
ISSN:0021-9673
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Shrnutí:This study details the effects of poly(styrene-divinylbenzene) (PS-DVB) frits in micro-HPLC columns for the separation of neutral and basic compounds. The procedure comprised the optimization of separations with only monolith or conventional fritted columns followed by method transference to short monolith-fritted columns. It was observed that a superior separation was achieved with the new columns compared to silica-fritted-packed columns once triethylamine (TEA) was added in small percentages. The separation of basic and neutral compounds was achieved in fast analysis times in the isocratic mode.
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ISSN:0021-9673
DOI:10.1016/j.chroma.2004.05.060