Diverse circovirus-like genome architectures revealed by environmental metagenomics

Single-stranded DNA (ssDNA) viruses with circular genomes are the smallest viruses known to infect eukaryotes. The present study identified 10 novel genomes similar to ssDNA circoviruses through data-mining of public viral metagenomes. The metagenomic libraries included samples from reclaimed water...

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Bibliographic Details
Published in:Journal of general virology Vol. 90; no. Pt 10; p. 2418
Main Authors: Rosario, Karyna, Duffy, Siobain, Breitbart, Mya
Format: Journal Article
Language:English
Published: England 01.10.2009
Subjects:
Amino Acid Sequence
Circovirus - genetics
Environmental Microbiology
Genome, Viral
Oceans and Seas
Phylogeny
Seawater - virology
Viral Proteins - chemistry
Viral Proteins - genetics
Water Microbiology
ISSN:1465-2099, 1465-2099
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Summary:Single-stranded DNA (ssDNA) viruses with circular genomes are the smallest viruses known to infect eukaryotes. The present study identified 10 novel genomes similar to ssDNA circoviruses through data-mining of public viral metagenomes. The metagenomic libraries included samples from reclaimed water and three different marine environments (Chesapeake Bay, British Columbia coastal waters and Sargasso Sea). All the genomes have similarities to the replication (Rep) protein of circoviruses; however, only half have genomic features consistent with known circoviruses. Some of the genomes exhibit a mixture of genomic features associated with different families of ssDNA viruses (i.e. circoviruses, geminiviruses and parvoviruses). Unique genome architectures and phylogenetic analysis of the Rep protein suggest that these viruses belong to novel genera and/or families. Investigating the complex community of ssDNA viruses in the environment can lead to the discovery of divergent species and help elucidate evolutionary links between ssDNA viruses.
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ISSN:1465-2099
1465-2099
DOI:10.1099/vir.0.012955-0