Adaptive mutability of colorectal cancers in response to targeted therapies

The emergence of drug resistance limits the efficacy of targeted therapies in human tumors. The prevalent view is that resistance is a fait accompli: when treatment is initiated, cancers already contain drug-resistant mutant cells. Bacteria exposed to antibiotics transiently increase their mutation...

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Vydané v:	Science (American Association for the Advancement of Science) Ročník 366; číslo 6472; s. 1473
Hlavní autori:	Russo, Mariangela, Crisafulli, Giovanni, Sogari, Alberto, Reilly, Nicole M, Arena, Sabrina, Lamba, Simona, Bartolini, Alice, Amodio, Vito, Magrì, Alessandro, Novara, Luca, Sarotto, Ivana, Nagel, Zachary D, Piett, Cortt G, Amatu, Alessio, Sartore-Bianchi, Andrea, Siena, Salvatore, Bertotti, Andrea, Trusolino, Livio, Corigliano, Mattia, Gherardi, Marco, Lagomarsino, Marco Cosentino, Di Nicolantonio, Federica, Bardelli, Alberto
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 20.12.2019
Predmet:	Adaptation, Biological - genetics Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics DNA Mismatch Repair - genetics Down-Regulation Drug Resistance, Neoplasm - genetics ErbB Receptors - antagonists & inhibitors Humans Molecular Targeted Therapy Mutagenesis Proto-Oncogene Proteins B-raf - antagonists & inhibitors Selection, Genetic
ISSN:	1095-9203, 1095-9203
On-line prístup:	Zistit podrobnosti o prístupe
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