Sry and the hesitant beginnings of male development

In mammals, Sry (sex-determining region Y gene) is the master regulator of male sex determination. The discovery of Sry in 1990 was expected to provide the key to unravelling the network of gene regulation underlying testis development. Intriguingly, no target gene of SRY protein has yet been discov...

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Bibliographic Details
Published in:	Developmental biology Vol. 302; no. 1; pp. 13 - 24
Main Authors:	Polanco, Juan Carlos, Koopman, Peter
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.02.2007
Subjects:	Amino Acid Sequence Animals Brain gender Evolution Female Gene Expression Regulation, Developmental Genes, sry High Mobility Group Proteins - genetics Humans Male Molecular mechanism Molecular Sequence Data Organ Specificity Sex determination Sex Determination Processes Sex Differentiation - genetics Sex-Determining Region Y Protein - chemistry Sex-Determining Region Y Protein - metabolism SOX9 Transcription Factor Sry Testis development Transcription Factors - genetics Testis development Evolution Brain gender Sry Sex determination Molecular mechanism
ISSN:	0012-1606, 1095-564X
Online Access:	Get full text
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