Sequential replay of nonspatial task states in the human hippocampus
Sequential neural activity patterns related to spatial experiences are "replayed" in the hippocampus of rodents during rest. We investigated whether replay of nonspatial sequences can be detected noninvasively in the human hippocampus. Participants underwent functional magnetic resonance i...
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| Vydáno v: | Science (American Association for the Advancement of Science) Ročník 364; číslo 6447 |
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| Hlavní autoři: | , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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United States
28.06.2019
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| ISSN: | 1095-9203, 1095-9203 |
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| Abstract | Sequential neural activity patterns related to spatial experiences are "replayed" in the hippocampus of rodents during rest. We investigated whether replay of nonspatial sequences can be detected noninvasively in the human hippocampus. Participants underwent functional magnetic resonance imaging (fMRI) while resting after performing a decision-making task with sequential structure. Hippocampal fMRI patterns recorded at rest reflected sequentiality of previously experienced task states, with consecutive patterns corresponding to nearby states. Hippocampal sequentiality correlated with the fidelity of task representations recorded in the orbitofrontal cortex during decision-making, which were themselves related to better task performance. Our findings suggest that hippocampal replay may be important for building representations of complex, abstract tasks elsewhere in the brain and establish feasibility of investigating fast replay signals with fMRI. |
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| AbstractList | Sequential neural activity patterns related to spatial experiences are "replayed" in the hippocampus of rodents during rest. We investigated whether replay of nonspatial sequences can be detected noninvasively in the human hippocampus. Participants underwent functional magnetic resonance imaging (fMRI) while resting after performing a decision-making task with sequential structure. Hippocampal fMRI patterns recorded at rest reflected sequentiality of previously experienced task states, with consecutive patterns corresponding to nearby states. Hippocampal sequentiality correlated with the fidelity of task representations recorded in the orbitofrontal cortex during decision-making, which were themselves related to better task performance. Our findings suggest that hippocampal replay may be important for building representations of complex, abstract tasks elsewhere in the brain and establish feasibility of investigating fast replay signals with fMRI. Sequential neural activity patterns related to spatial experiences are "replayed" in the hippocampus of rodents during rest. We investigated whether replay of nonspatial sequences can be detected noninvasively in the human hippocampus. Participants underwent functional magnetic resonance imaging (fMRI) while resting after performing a decision-making task with sequential structure. Hippocampal fMRI patterns recorded at rest reflected sequentiality of previously experienced task states, with consecutive patterns corresponding to nearby states. Hippocampal sequentiality correlated with the fidelity of task representations recorded in the orbitofrontal cortex during decision-making, which were themselves related to better task performance. Our findings suggest that hippocampal replay may be important for building representations of complex, abstract tasks elsewhere in the brain and establish feasibility of investigating fast replay signals with fMRI.Sequential neural activity patterns related to spatial experiences are "replayed" in the hippocampus of rodents during rest. We investigated whether replay of nonspatial sequences can be detected noninvasively in the human hippocampus. Participants underwent functional magnetic resonance imaging (fMRI) while resting after performing a decision-making task with sequential structure. Hippocampal fMRI patterns recorded at rest reflected sequentiality of previously experienced task states, with consecutive patterns corresponding to nearby states. Hippocampal sequentiality correlated with the fidelity of task representations recorded in the orbitofrontal cortex during decision-making, which were themselves related to better task performance. Our findings suggest that hippocampal replay may be important for building representations of complex, abstract tasks elsewhere in the brain and establish feasibility of investigating fast replay signals with fMRI. |
| Author | Niv, Yael Schuck, Nicolas W |
| Author_xml | – sequence: 1 givenname: Nicolas W orcidid: 0000-0002-0150-8776 surname: Schuck fullname: Schuck, Nicolas W email: schuck@mpib-berlin.mpg.de, yael@princeton.edu organization: Princeton Neuroscience Institute and Department of Psychology, Princeton University, Washington Road, Princeton, NJ 08544, USA – sequence: 2 givenname: Yael orcidid: 0000-0002-0259-8371 surname: Niv fullname: Niv, Yael email: schuck@mpib-berlin.mpg.de, yael@princeton.edu organization: Princeton Neuroscience Institute and Department of Psychology, Princeton University, Washington Road, Princeton, NJ 08544, USA. schuck@mpib-berlin.mpg.de yael@princeton.edu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31249030$$D View this record in MEDLINE/PubMed |
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| Copyright | Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. |
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| Title | Sequential replay of nonspatial task states in the human hippocampus |
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