Combined Effect of PNPLA3, TM6SF2, and HSD17B13 Variants on Risk of Cirrhosis and Hepatocellular Carcinoma in the General Population

Background and Aims We hypothesized that a genetic risk score (GRS) for fatty liver disease influences the risk of cirrhosis and hepatocellular carcinoma (HCC). Three genetic variants (patatin‐like phospholipase domain–containing protein 3 [PNPLA3] p.I148M; transmembrane 6, superfamily member 2 [TM6...

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Bibliographic Details
Published in:	Hepatology (Baltimore, Md.) Vol. 72; no. 3; pp. 845 - 856
Main Authors:	Gellert‐Kristensen, Helene, Richardson, Tom G., Davey Smith, George, Nordestgaard, Børge G., Tybjærg‐Hansen, Anne, Stender, Stefan
Format:	Journal Article
Language:	English
Published:	United States Wolters Kluwer Health, Inc 01.09.2020
Subjects:	17-Hydroxysteroid Dehydrogenases - genetics Alanine Alanine transaminase Alanine Transaminase - blood Biobanks Carcinoma, Hepatocellular - blood Carcinoma, Hepatocellular - epidemiology Carcinoma, Hepatocellular - genetics Cirrhosis Denmark - epidemiology Fatty liver Female Genetic diversity Genetic Predisposition to Disease Health risk assessment Hepatocellular carcinoma Hepatology Humans Lipase - genetics Liver cancer Liver cirrhosis Liver Cirrhosis - blood Liver Cirrhosis - epidemiology Liver Cirrhosis - genetics Liver diseases Liver Neoplasms - blood Liver Neoplasms - epidemiology Liver Neoplasms - genetics Male Membrane Proteins - genetics Middle Aged Non-alcoholic Fatty Liver Disease - blood Non-alcoholic Fatty Liver Disease - diagnosis Non-alcoholic Fatty Liver Disease - epidemiology Phospholipase Polymorphism, Single Nucleotide Risk Factors United Kingdom - epidemiology Denmark United Kingdom United Kingdom > UK
ISSN:	0270-9139, 1527-3350, 1527-3350
Online Access:	Get full text
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