Intrinsic and extrinsic regulation of human skin melanogenesis and pigmentation

In human skin, melanogenesis is a tightly regulated process. Indeed, several extracellular signals are transduced via dedicated signalling pathways and mostly converge to MITF, a transcription factor integrating upstream signalling and regulating downstream genes involved in the various inherent mec...

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Bibliographic Details
Published in:	International journal of cosmetic science Vol. 40; no. 4; pp. 328 - 347
Main Authors:	Serre, C., Busuttil, V., Botto, J.‐M.
Format:	Journal Article
Language:	English
Published:	England Wiley Subscription Services, Inc 01.08.2018
Subjects:	computer modelling Convergence Environmental Pollutants - toxicity environmental pollution Enzymes Humans Irradiation Keratinocytes Melanin Melanins - biosynthesis Melanocytes Melanocytes - metabolism melanogenesis Melanosomes Melanosomes - metabolism Microphthalmia-associated transcription factor Microphthalmia-Associated Transcription Factor - metabolism MicroRNAs - metabolism miRNA ncRNAs Pigmentation Pigments Proteins Receptors, G-Protein-Coupled - metabolism RNA, Long Noncoding - metabolism Signal processing Signal transduction Signaling Skin Skin - drug effects Skin - metabolism Skin - radiation effects skin physiology/structure Skin Pigmentation Sunlight Tyrosinase Ultraviolet radiation melanogenesis computer modelling skin physiology/structure ncRNAs environmental pollution
ISSN:	0142-5463, 1468-2494, 1468-2494
Online Access:	Get full text
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