Intrinsic and extrinsic regulation of human skin melanogenesis and pigmentation

In human skin, melanogenesis is a tightly regulated process. Indeed, several extracellular signals are transduced via dedicated signalling pathways and mostly converge to MITF, a transcription factor integrating upstream signalling and regulating downstream genes involved in the various inherent mec...

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Vydáno v:International journal of cosmetic science Ročník 40; číslo 4; s. 328 - 347
Hlavní autoři: Serre, C., Busuttil, V., Botto, J.‐M.
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Wiley Subscription Services, Inc 01.08.2018
Témata:
computer modelling
Convergence
Environmental Pollutants - toxicity
environmental pollution
Enzymes
Humans
Irradiation
Keratinocytes
Melanin
Melanins - biosynthesis
Melanocytes
Melanocytes - metabolism
melanogenesis
Melanosomes
Melanosomes - metabolism
Microphthalmia-associated transcription factor
Microphthalmia-Associated Transcription Factor - metabolism
MicroRNAs - metabolism
miRNA
ncRNAs
Pigmentation
Pigments
Proteins
Receptors, G-Protein-Coupled - metabolism
RNA, Long Noncoding - metabolism
Signal processing
Signal transduction
Signaling
Skin
Skin - drug effects
Skin - metabolism
Skin - radiation effects
skin physiology/structure
Skin Pigmentation
Sunlight
Tyrosinase
Ultraviolet radiation
melanogenesis
computer modelling
skin physiology/structure
ncRNAs
environmental pollution
ISSN:0142-5463, 1468-2494, 1468-2494
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Abstract In human skin, melanogenesis is a tightly regulated process. Indeed, several extracellular signals are transduced via dedicated signalling pathways and mostly converge to MITF, a transcription factor integrating upstream signalling and regulating downstream genes involved in the various inherent mechanisms modulating melanogenesis. The synthesis of melanin pigments occurs in melanocytes inside melanosomes where melanogenic enzymes (tyrosinase and related proteins) are addressed with the help of specific protein complexes. The melanosomes loaded with melanin are then transferred to keratinocytes. A more elaborate level of melanogenesis regulation comes into play via the action of non‐coding RNAs (microRNAs, lncRNAs). Besides this canonical regulation, melanogenesis can also be modulated by other non‐specific intrinsic pathways (hormonal environment, inflammation) and by extrinsic factors (solar irradiation such as ultraviolet irradiation, environmental pollution). We developed a bioinformatic interaction network gathering the multiple aspects of melanogenesis and skin pigmentation as a resource to better understand and study skin pigmentation biology. Résumé Dans la peau humaine, le processus de la mélanogenèse est extrêmement contrôlé. En effet, divers signaux extracellulaires sont transduits via des voies de signalisation dédiées qui convergent essentiellement vers le facteur de transcription MITF. Ce dernier intègre cette signalisation en amont et régule alors la transcription de gènes impliqués dans les divers mécanismes inhérents à la modulation de la mélanogenèse. La synthèse des pigments de mélanine se produit dans les mélanocytes, à l'intérieur des mélanosomes dans lesquels les enzymes de la mélanogenèse (tyrosinase et protéines apparentées) sont adressées à l'aide de complexes protéiques spécifiques. Les mélanosomes ainsi chargés en mélanine sont ensuite transférés aux kératinocytes. Un niveau plus élaboré de régulation de la mélanogenèse entre aussi en jeu au travers de l'action d’ARNs non codants (microARNs et lncRNAs). Outre cette régulation canonique, la mélanogenèse peut également être modulée par des voies intrinsèques non spécifiques telles l'environnement hormonal et l'inflammation, et par des facteurs extrinsèques, comme le rayonnement solaire et la pollution environnementale. Nous avons par ailleurs développé un réseau d'interactions gènes/protéines regroupant les multiples aspects de la régulation de la mélanogenèse et de la pigmentation de la peau grâce à l'outil bioinformatique. Ce réseau constitue une ressource pour mieux comprendre et étudier la biologie de la pigmentation de la peau.
AbstractList In human skin, melanogenesis is a tightly regulated process. Indeed, several extracellular signals are transduced via dedicated signalling pathways and mostly converge to MITF , a transcription factor integrating upstream signalling and regulating downstream genes involved in the various inherent mechanisms modulating melanogenesis. The synthesis of melanin pigments occurs in melanocytes inside melanosomes where melanogenic enzymes (tyrosinase and related proteins) are addressed with the help of specific protein complexes. The melanosomes loaded with melanin are then transferred to keratinocytes. A more elaborate level of melanogenesis regulation comes into play via the action of non‐coding RNA s (micro RNA s, lnc RNA s). Besides this canonical regulation, melanogenesis can also be modulated by other non‐specific intrinsic pathways (hormonal environment, inflammation) and by extrinsic factors (solar irradiation such as ultraviolet irradiation, environmental pollution). We developed a bioinformatic interaction network gathering the multiple aspects of melanogenesis and skin pigmentation as a resource to better understand and study skin pigmentation biology. Dans la peau humaine, le processus de la mélanogenèse est extrêmement contrôlé. En effet, divers signaux extracellulaires sont transduits via des voies de signalisation dédiées qui convergent essentiellement vers le facteur de transcription MITF . Ce dernier intègre cette signalisation en amont et régule alors la transcription de gènes impliqués dans les divers mécanismes inhérents à la modulation de la mélanogenèse. La synthèse des pigments de mélanine se produit dans les mélanocytes, à l'intérieur des mélanosomes dans lesquels les enzymes de la mélanogenèse (tyrosinase et protéines apparentées) sont adressées à l'aide de complexes protéiques spécifiques. Les mélanosomes ainsi chargés en mélanine sont ensuite transférés aux kératinocytes. Un niveau plus élaboré de régulation de la mélanogenèse entre aussi en jeu au travers de l'action d’ ARN s non codants (micro ARN s et lnc RNA s). Outre cette régulation canonique, la mélanogenèse peut également être modulée par des voies intrinsèques non spécifiques telles l'environnement hormonal et l'inflammation, et par des facteurs extrinsèques, comme le rayonnement solaire et la pollution environnementale. Nous avons par ailleurs développé un réseau d'interactions gènes/protéines regroupant les multiples aspects de la régulation de la mélanogenèse et de la pigmentation de la peau grâce à l'outil bioinformatique. Ce réseau constitue une ressource pour mieux comprendre et étudier la biologie de la pigmentation de la peau.
In human skin, melanogenesis is a tightly regulated process. Indeed, several extracellular signals are transduced via dedicated signalling pathways and mostly converge to MITF, a transcription factor integrating upstream signalling and regulating downstream genes involved in the various inherent mechanisms modulating melanogenesis. The synthesis of melanin pigments occurs in melanocytes inside melanosomes where melanogenic enzymes (tyrosinase and related proteins) are addressed with the help of specific protein complexes. The melanosomes loaded with melanin are then transferred to keratinocytes. A more elaborate level of melanogenesis regulation comes into play via the action of non-coding RNAs (microRNAs, lncRNAs). Besides this canonical regulation, melanogenesis can also be modulated by other non-specific intrinsic pathways (hormonal environment, inflammation) and by extrinsic factors (solar irradiation such as ultraviolet irradiation, environmental pollution). We developed a bioinformatic interaction network gathering the multiple aspects of melanogenesis and skin pigmentation as a resource to better understand and study skin pigmentation biology.
In human skin, melanogenesis is a tightly regulated process. Indeed, several extracellular signals are transduced via dedicated signalling pathways and mostly converge to MITF, a transcription factor integrating upstream signalling and regulating downstream genes involved in the various inherent mechanisms modulating melanogenesis. The synthesis of melanin pigments occurs in melanocytes inside melanosomes where melanogenic enzymes (tyrosinase and related proteins) are addressed with the help of specific protein complexes. The melanosomes loaded with melanin are then transferred to keratinocytes. A more elaborate level of melanogenesis regulation comes into play via the action of non‐coding RNAs (microRNAs, lncRNAs). Besides this canonical regulation, melanogenesis can also be modulated by other non‐specific intrinsic pathways (hormonal environment, inflammation) and by extrinsic factors (solar irradiation such as ultraviolet irradiation, environmental pollution). We developed a bioinformatic interaction network gathering the multiple aspects of melanogenesis and skin pigmentation as a resource to better understand and study skin pigmentation biology. Résumé Dans la peau humaine, le processus de la mélanogenèse est extrêmement contrôlé. En effet, divers signaux extracellulaires sont transduits via des voies de signalisation dédiées qui convergent essentiellement vers le facteur de transcription MITF. Ce dernier intègre cette signalisation en amont et régule alors la transcription de gènes impliqués dans les divers mécanismes inhérents à la modulation de la mélanogenèse. La synthèse des pigments de mélanine se produit dans les mélanocytes, à l'intérieur des mélanosomes dans lesquels les enzymes de la mélanogenèse (tyrosinase et protéines apparentées) sont adressées à l'aide de complexes protéiques spécifiques. Les mélanosomes ainsi chargés en mélanine sont ensuite transférés aux kératinocytes. Un niveau plus élaboré de régulation de la mélanogenèse entre aussi en jeu au travers de l'action d’ARNs non codants (microARNs et lncRNAs). Outre cette régulation canonique, la mélanogenèse peut également être modulée par des voies intrinsèques non spécifiques telles l'environnement hormonal et l'inflammation, et par des facteurs extrinsèques, comme le rayonnement solaire et la pollution environnementale. Nous avons par ailleurs développé un réseau d'interactions gènes/protéines regroupant les multiples aspects de la régulation de la mélanogenèse et de la pigmentation de la peau grâce à l'outil bioinformatique. Ce réseau constitue une ressource pour mieux comprendre et étudier la biologie de la pigmentation de la peau.
In human skin, melanogenesis is a tightly regulated process. Indeed, several extracellular signals are transduced via dedicated signalling pathways and mostly converge to MITF, a transcription factor integrating upstream signalling and regulating downstream genes involved in the various inherent mechanisms modulating melanogenesis. The synthesis of melanin pigments occurs in melanocytes inside melanosomes where melanogenic enzymes (tyrosinase and related proteins) are addressed with the help of specific protein complexes. The melanosomes loaded with melanin are then transferred to keratinocytes. A more elaborate level of melanogenesis regulation comes into play via the action of non-coding RNAs (microRNAs, lncRNAs). Besides this canonical regulation, melanogenesis can also be modulated by other non-specific intrinsic pathways (hormonal environment, inflammation) and by extrinsic factors (solar irradiation such as ultraviolet irradiation, environmental pollution). We developed a bioinformatic interaction network gathering the multiple aspects of melanogenesis and skin pigmentation as a resource to better understand and study skin pigmentation biology.In human skin, melanogenesis is a tightly regulated process. Indeed, several extracellular signals are transduced via dedicated signalling pathways and mostly converge to MITF, a transcription factor integrating upstream signalling and regulating downstream genes involved in the various inherent mechanisms modulating melanogenesis. The synthesis of melanin pigments occurs in melanocytes inside melanosomes where melanogenic enzymes (tyrosinase and related proteins) are addressed with the help of specific protein complexes. The melanosomes loaded with melanin are then transferred to keratinocytes. A more elaborate level of melanogenesis regulation comes into play via the action of non-coding RNAs (microRNAs, lncRNAs). Besides this canonical regulation, melanogenesis can also be modulated by other non-specific intrinsic pathways (hormonal environment, inflammation) and by extrinsic factors (solar irradiation such as ultraviolet irradiation, environmental pollution). We developed a bioinformatic interaction network gathering the multiple aspects of melanogenesis and skin pigmentation as a resource to better understand and study skin pigmentation biology.
Author Botto, J.‐M.
Busuttil, V.
Serre, C.
Author_xml – sequence: 1
  givenname: C.
  surname: Serre
  fullname: Serre, C.
  organization: Ashland
– sequence: 2
  givenname: V.
  surname: Busuttil
  fullname: Busuttil, V.
  organization: Ashland
– sequence: 3
  givenname: J.‐M.
  orcidid: 0000-0002-6182-4236
  surname: Botto
  fullname: Botto, J.‐M.
  email: jbotto@ashland.com
  organization: Ashland
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29752874$$D View this record in MEDLINE/PubMed
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Issue 4
Keywords melanogenesis
computer modelling
skin physiology/structure
ncRNAs
environmental pollution
Language English
License 2018 Society of Cosmetic Scientists and the Société Française de Cosmétologie.
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Snippet In human skin, melanogenesis is a tightly regulated process. Indeed, several extracellular signals are transduced via dedicated signalling pathways and mostly...
In human skin, melanogenesis is a tightly regulated process. Indeed, several extracellular signals are transduced via dedicated signalling pathways and mostly...
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StartPage 328
SubjectTerms computer modelling
Convergence
Environmental Pollutants - toxicity
environmental pollution
Enzymes
Humans
Irradiation
Keratinocytes
Melanin
Melanins - biosynthesis
Melanocytes
Melanocytes - metabolism
melanogenesis
Melanosomes
Melanosomes - metabolism
Microphthalmia-associated transcription factor
Microphthalmia-Associated Transcription Factor - metabolism
MicroRNAs - metabolism
miRNA
ncRNAs
Pigmentation
Pigments
Proteins
Receptors, G-Protein-Coupled - metabolism
RNA, Long Noncoding - metabolism
Signal processing
Signal transduction
Signaling
Skin
Skin - drug effects
Skin - metabolism
Skin - radiation effects
skin physiology/structure
Skin Pigmentation
Sunlight
Tyrosinase
Ultraviolet radiation
Title Intrinsic and extrinsic regulation of human skin melanogenesis and pigmentation
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fics.12466
https://www.ncbi.nlm.nih.gov/pubmed/29752874
https://www.proquest.com/docview/2100344769
https://www.proquest.com/docview/2038277967
Volume 40
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