Selenoglutathione-Mediated Rescue of Kinetically Trapped Intermediates in Oxidative Protein Folding

Selenoglutathione has been shown to have considerable potential as a catalyst of oxidative protein folding. Here we examine how this reagent modulates the folding pathway of bovine pancreatic trypsin inhibitor (BPTI) and show that the diselenide increases the efficiency of this process primarily by...

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Veröffentlicht in:	Israel journal of chemistry Jg. 51; H. 8-9; S. 953 - 959
Hauptverfasser:	Metanis, Norman, Foletti, Carlotta, Beld , Joris, Hilvert, Donald
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Weinheim WILEY-VCH Verlag 01.11.2011 WILEY‐VCH Verlag Wiley Subscription Services, Inc
Schlagworte:	bovine pancreatic trypsin inhibitor Catalysts Conversion Folding Pathways Protein folding Proteins redox chemistry selenoglutathione thiol/disulfide exchange Trypsin inhibitors
ISSN:	0021-2148, 1869-5868
Online-Zugang:	Volltext
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