Significance of presence of microvascular invasion in specimens obtained after surgical treatment of hepatocellular carcinoma

Partial hepatectomy and liver transplantation are potentially curative treatments in selected patients with hepatocellular carcinoma (HCC). Unfortunately, a high postoperative tumor recurrence rate significantly decreases long‐term survival outcomes. Among multiple prognostic factors, the presence o...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Journal of gastroenterology and hepatology Ročník 33; číslo 2; s. 347 - 354
Hlavní autoři: Zhang, Xiaofeng, Li, Jun, Shen, Feng, Lau, Wan Yee
Médium: Journal Article
Jazyk:angličtina
Vydáno: Australia Wiley Subscription Services, Inc 01.02.2018
Témata:
Carcinoma, Hepatocellular - blood supply
Carcinoma, Hepatocellular - diagnostic imaging
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - surgery
Decision making
Hepatectomy
Hepatocellular carcinoma
Humans
Liver cancer
Liver Neoplasms - blood supply
Liver Neoplasms - diagnostic imaging
Liver Neoplasms - pathology
Liver Neoplasms - surgery
liver resection
Liver Transplantation
Medical prognosis
Metastases
microvascular invasion
Microvasculature
Microvessels - pathology
Neoplasm Invasiveness
prediction
Transplantation
prediction
liver resection
hepatocellular carcinoma
liver transplantation
microvascular invasion
ISSN:0815-9319, 1440-1746, 1440-1746
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Partial hepatectomy and liver transplantation are potentially curative treatments in selected patients with hepatocellular carcinoma (HCC). Unfortunately, a high postoperative tumor recurrence rate significantly decreases long‐term survival outcomes. Among multiple prognostic factors, the presence of microvascular invasion (MVI) has increasingly been recognized to reflect enhanced abilities of local invasion and distant metastasis of HCC. Unfortunately, MVI can only currently be identified through histopathological studies on resected surgical specimens. Accurate preoperative tests to predict the presence of MVI are urgently needed. This paper reviews the current studies on incidence, pathological diagnosis, and classification of MVI; possible mechanisms of MVI formation; and preoperative prediction of the presence of MVI. Furthermore, focusing on how the postoperative management can be improved on histopathologically confirmed patients with HCC with MVI, and the potential roles of using predictive tests to estimate the risk of presence of MVI, helps in preoperative therapeutic decision‐making in patients with HCC.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ISSN:0815-9319
1440-1746
1440-1746
DOI:10.1111/jgh.13843