Significance of presence of microvascular invasion in specimens obtained after surgical treatment of hepatocellular carcinoma

Partial hepatectomy and liver transplantation are potentially curative treatments in selected patients with hepatocellular carcinoma (HCC). Unfortunately, a high postoperative tumor recurrence rate significantly decreases long‐term survival outcomes. Among multiple prognostic factors, the presence o...

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Published in:	Journal of gastroenterology and hepatology Vol. 33; no. 2; pp. 347 - 354
Main Authors:	Zhang, Xiaofeng, Li, Jun, Shen, Feng, Lau, Wan Yee
Format:	Journal Article
Language:	English
Published:	Australia Wiley Subscription Services, Inc 01.02.2018
Subjects:	Carcinoma, Hepatocellular - blood supply Carcinoma, Hepatocellular - diagnostic imaging Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - surgery Decision making Hepatectomy Hepatocellular carcinoma Humans Liver cancer Liver Neoplasms - blood supply Liver Neoplasms - diagnostic imaging Liver Neoplasms - pathology Liver Neoplasms - surgery liver resection Liver Transplantation Medical prognosis Metastases microvascular invasion Microvasculature Microvessels - pathology Neoplasm Invasiveness prediction Transplantation prediction liver resection hepatocellular carcinoma liver transplantation microvascular invasion
ISSN:	0815-9319, 1440-1746, 1440-1746
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Abstract	Partial hepatectomy and liver transplantation are potentially curative treatments in selected patients with hepatocellular carcinoma (HCC). Unfortunately, a high postoperative tumor recurrence rate significantly decreases long‐term survival outcomes. Among multiple prognostic factors, the presence of microvascular invasion (MVI) has increasingly been recognized to reflect enhanced abilities of local invasion and distant metastasis of HCC. Unfortunately, MVI can only currently be identified through histopathological studies on resected surgical specimens. Accurate preoperative tests to predict the presence of MVI are urgently needed. This paper reviews the current studies on incidence, pathological diagnosis, and classification of MVI; possible mechanisms of MVI formation; and preoperative prediction of the presence of MVI. Furthermore, focusing on how the postoperative management can be improved on histopathologically confirmed patients with HCC with MVI, and the potential roles of using predictive tests to estimate the risk of presence of MVI, helps in preoperative therapeutic decision‐making in patients with HCC.
AbstractList	Partial hepatectomy and liver transplantation are potentially curative treatments in selected patients with hepatocellular carcinoma (HCC). Unfortunately, a high postoperative tumor recurrence rate significantly decreases long-term survival outcomes. Among multiple prognostic factors, the presence of microvascular invasion (MVI) has increasingly been recognized to reflect enhanced abilities of local invasion and distant metastasis of HCC. Unfortunately, MVI can only currently be identified through histopathological studies on resected surgical specimens. Accurate preoperative tests to predict the presence of MVI are urgently needed. This paper reviews the current studies on incidence, pathological diagnosis, and classification of MVI; possible mechanisms of MVI formation; and preoperative prediction of the presence of MVI. Furthermore, focusing on how the postoperative management can be improved on histopathologically confirmed patients with HCC with MVI, and the potential roles of using predictive tests to estimate the risk of presence of MVI, helps in preoperative therapeutic decision-making in patients with HCC. Partial hepatectomy and liver transplantation are potentially curative treatments in selected patients with hepatocellular carcinoma (HCC). Unfortunately, a high postoperative tumor recurrence rate significantly decreases long-term survival outcomes. Among multiple prognostic factors, the presence of microvascular invasion (MVI) has increasingly been recognized to reflect enhanced abilities of local invasion and distant metastasis of HCC. Unfortunately, MVI can only currently be identified through histopathological studies on resected surgical specimens. Accurate preoperative tests to predict the presence of MVI are urgently needed. This paper reviews the current studies on incidence, pathological diagnosis, and classification of MVI; possible mechanisms of MVI formation; and preoperative prediction of the presence of MVI. Furthermore, focusing on how the postoperative management can be improved on histopathologically confirmed patients with HCC with MVI, and the potential roles of using predictive tests to estimate the risk of presence of MVI, helps in preoperative therapeutic decision-making in patients with HCC.Partial hepatectomy and liver transplantation are potentially curative treatments in selected patients with hepatocellular carcinoma (HCC). Unfortunately, a high postoperative tumor recurrence rate significantly decreases long-term survival outcomes. Among multiple prognostic factors, the presence of microvascular invasion (MVI) has increasingly been recognized to reflect enhanced abilities of local invasion and distant metastasis of HCC. Unfortunately, MVI can only currently be identified through histopathological studies on resected surgical specimens. Accurate preoperative tests to predict the presence of MVI are urgently needed. This paper reviews the current studies on incidence, pathological diagnosis, and classification of MVI; possible mechanisms of MVI formation; and preoperative prediction of the presence of MVI. Furthermore, focusing on how the postoperative management can be improved on histopathologically confirmed patients with HCC with MVI, and the potential roles of using predictive tests to estimate the risk of presence of MVI, helps in preoperative therapeutic decision-making in patients with HCC.
Author	Li, Jun Shen, Feng Lau, Wan Yee Zhang, Xiaofeng
Author_xml	– sequence: 1 givenname: Xiaofeng surname: Zhang fullname: Zhang, Xiaofeng organization: Second Military Medical University – sequence: 2 givenname: Jun surname: Li fullname: Li, Jun organization: Second Military Medical University – sequence: 3 givenname: Feng orcidid: 0000-0003-1767-5437 surname: Shen fullname: Shen, Feng email: shenfengehbh@sina.com organization: Second Military Medical University – sequence: 4 givenname: Wan Yee surname: Lau fullname: Lau, Wan Yee email: josephlau@cuhk.edu.hk organization: the Chinese University of Hong Kong
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Snippet	Partial hepatectomy and liver transplantation are potentially curative treatments in selected patients with hepatocellular carcinoma (HCC). Unfortunately, a...
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SubjectTerms	Carcinoma, Hepatocellular - blood supply Carcinoma, Hepatocellular - diagnostic imaging Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - surgery Decision making Hepatectomy Hepatocellular carcinoma Humans Liver cancer Liver Neoplasms - blood supply Liver Neoplasms - diagnostic imaging Liver Neoplasms - pathology Liver Neoplasms - surgery liver resection Liver Transplantation Medical prognosis Metastases microvascular invasion Microvasculature Microvessels - pathology Neoplasm Invasiveness prediction Transplantation
Title	Significance of presence of microvascular invasion in specimens obtained after surgical treatment of hepatocellular carcinoma
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