Significance of presence of microvascular invasion in specimens obtained after surgical treatment of hepatocellular carcinoma

Partial hepatectomy and liver transplantation are potentially curative treatments in selected patients with hepatocellular carcinoma (HCC). Unfortunately, a high postoperative tumor recurrence rate significantly decreases long‐term survival outcomes. Among multiple prognostic factors, the presence o...

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Published in:	Journal of gastroenterology and hepatology Vol. 33; no. 2; pp. 347 - 354
Main Authors:	Zhang, Xiaofeng, Li, Jun, Shen, Feng, Lau, Wan Yee
Format:	Journal Article
Language:	English
Published:	Australia Wiley Subscription Services, Inc 01.02.2018
Subjects:	Carcinoma, Hepatocellular - blood supply Carcinoma, Hepatocellular - diagnostic imaging Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - surgery Decision making Hepatectomy Hepatocellular carcinoma Humans Liver cancer Liver Neoplasms - blood supply Liver Neoplasms - diagnostic imaging Liver Neoplasms - pathology Liver Neoplasms - surgery liver resection Liver Transplantation Medical prognosis Metastases microvascular invasion Microvasculature Microvessels - pathology Neoplasm Invasiveness prediction Transplantation prediction liver resection hepatocellular carcinoma liver transplantation microvascular invasion
ISSN:	0815-9319, 1440-1746, 1440-1746
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Abstract	Partial hepatectomy and liver transplantation are potentially curative treatments in selected patients with hepatocellular carcinoma (HCC). Unfortunately, a high postoperative tumor recurrence rate significantly decreases long‐term survival outcomes. Among multiple prognostic factors, the presence of microvascular invasion (MVI) has increasingly been recognized to reflect enhanced abilities of local invasion and distant metastasis of HCC. Unfortunately, MVI can only currently be identified through histopathological studies on resected surgical specimens. Accurate preoperative tests to predict the presence of MVI are urgently needed. This paper reviews the current studies on incidence, pathological diagnosis, and classification of MVI; possible mechanisms of MVI formation; and preoperative prediction of the presence of MVI. Furthermore, focusing on how the postoperative management can be improved on histopathologically confirmed patients with HCC with MVI, and the potential roles of using predictive tests to estimate the risk of presence of MVI, helps in preoperative therapeutic decision‐making in patients with HCC.
AbstractList	Partial hepatectomy and liver transplantation are potentially curative treatments in selected patients with hepatocellular carcinoma (HCC). Unfortunately, a high postoperative tumor recurrence rate significantly decreases long-term survival outcomes. Among multiple prognostic factors, the presence of microvascular invasion (MVI) has increasingly been recognized to reflect enhanced abilities of local invasion and distant metastasis of HCC. Unfortunately, MVI can only currently be identified through histopathological studies on resected surgical specimens. Accurate preoperative tests to predict the presence of MVI are urgently needed. This paper reviews the current studies on incidence, pathological diagnosis, and classification of MVI; possible mechanisms of MVI formation; and preoperative prediction of the presence of MVI. Furthermore, focusing on how the postoperative management can be improved on histopathologically confirmed patients with HCC with MVI, and the potential roles of using predictive tests to estimate the risk of presence of MVI, helps in preoperative therapeutic decision-making in patients with HCC. Partial hepatectomy and liver transplantation are potentially curative treatments in selected patients with hepatocellular carcinoma (HCC). Unfortunately, a high postoperative tumor recurrence rate significantly decreases long-term survival outcomes. Among multiple prognostic factors, the presence of microvascular invasion (MVI) has increasingly been recognized to reflect enhanced abilities of local invasion and distant metastasis of HCC. Unfortunately, MVI can only currently be identified through histopathological studies on resected surgical specimens. Accurate preoperative tests to predict the presence of MVI are urgently needed. This paper reviews the current studies on incidence, pathological diagnosis, and classification of MVI; possible mechanisms of MVI formation; and preoperative prediction of the presence of MVI. Furthermore, focusing on how the postoperative management can be improved on histopathologically confirmed patients with HCC with MVI, and the potential roles of using predictive tests to estimate the risk of presence of MVI, helps in preoperative therapeutic decision-making in patients with HCC.Partial hepatectomy and liver transplantation are potentially curative treatments in selected patients with hepatocellular carcinoma (HCC). Unfortunately, a high postoperative tumor recurrence rate significantly decreases long-term survival outcomes. Among multiple prognostic factors, the presence of microvascular invasion (MVI) has increasingly been recognized to reflect enhanced abilities of local invasion and distant metastasis of HCC. Unfortunately, MVI can only currently be identified through histopathological studies on resected surgical specimens. Accurate preoperative tests to predict the presence of MVI are urgently needed. This paper reviews the current studies on incidence, pathological diagnosis, and classification of MVI; possible mechanisms of MVI formation; and preoperative prediction of the presence of MVI. Furthermore, focusing on how the postoperative management can be improved on histopathologically confirmed patients with HCC with MVI, and the potential roles of using predictive tests to estimate the risk of presence of MVI, helps in preoperative therapeutic decision-making in patients with HCC.
Author	Li, Jun Shen, Feng Lau, Wan Yee Zhang, Xiaofeng
Author_xml	– sequence: 1 givenname: Xiaofeng surname: Zhang fullname: Zhang, Xiaofeng organization: Second Military Medical University – sequence: 2 givenname: Jun surname: Li fullname: Li, Jun organization: Second Military Medical University – sequence: 3 givenname: Feng orcidid: 0000-0003-1767-5437 surname: Shen fullname: Shen, Feng email: shenfengehbh@sina.com organization: Second Military Medical University – sequence: 4 givenname: Wan Yee surname: Lau fullname: Lau, Wan Yee email: josephlau@cuhk.edu.hk organization: the Chinese University of Hong Kong
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Cites_doi	10.1111/jgh.12358 10.1038/bjc.2014.19 10.1111/hepr.12159 10.4254/wjh.v7.i1.40 10.1016/j.jhep.2016.05.044 10.3322/caac.21161 10.1053/j.gastro.2009.06.003 10.1002/1097-0142(20010615)91:12<2378::AID-CNCR1271>3.0.CO;2-2 10.1002/jso.21631 10.1016/j.ejso.2013.04.003 10.1016/j.jhep.2014.11.005 10.1016/j.jhep.2014.01.022 10.1126/science.1203543 10.1245/s10434-008-9846-9 10.1001/archsurg.133.2.183 10.3322/caac.21262 10.1053/j.gastro.2015.02.055 10.1016/j.jhep.2011.07.007 10.1016/j.ctrv.2006.08.002 10.1111/jgh.12672 10.1002/lt.22362 10.1016/j.jhep.2009.12.037 10.1634/theoncologist.2011-0447 10.1016/j.jhep.2011.02.034 10.1007/s00595-016-1320-x 10.1159/000451015 10.1016/j.ccr.2012.07.023 10.1002/lt.20472 10.3760/cma.j.issn.0366-6999.20120126 10.1038/nrc2621 10.1053/j.gastro.2015.12.041 10.1055/s-0034-1394137 10.1097/TP.0b013e3182187cf0 10.1007/s00432-016-2286-1 10.1111/j.1477-2574.2009.00128.x 10.1007/s00423-011-0784-9 10.1002/lt.20808 10.1097/SLA.0b013e31821ad884 10.1097/SLA.0b013e3181961c16 10.1002/hep.25895 10.1002/jso.20953 10.1016/j.surg.2013.10.009 10.2214/AJR.13.10595 10.1016/j.tranon.2016.03.002 10.1016/j.ejca.2016.04.011 10.18632/oncotarget.4098 10.3892/ijo.2012.1711 10.1186/s12957-016-0855-z 10.1001/jamasurg.2015.4257 10.3109/07357907.2010.483500 10.3748/wjg.v22.i42.9279 10.1097/MD.0000000000002665 10.1016/S1091-255X(01)00015-4 10.1097/SLA.0000000000001556 10.1007/s11605-014-2646-6 10.1245/s10434-011-2195-0 10.1016/S1470-2045(08)70284-5 10.1186/1471-2407-14-38 10.1002/jso.24123 10.1245/s10434-007-9685-0 10.1002/lt.21738 10.3748/wjg.v21.i15.4627 10.1245/s10434-012-2513-1 10.1002/cncr.24513 10.1245/s10434-013-3144-x 10.1002/hep.27877 10.1097/00000478-200201000-00003 10.18632/oncotarget.7649 10.18632/oncotarget.8333
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References	2001; 91 2010; 12 2015; 148 2006; 32 2013; 20 2010; 102 2011; 55 2012; 19 2012; 17 2014; 29 2012; 59 2011; 17 2013; 8 2012; 56 2014; 60 2016; 263 2009; 115 2011; 396 2014; 127 2009; 10 2010; 28 2016; 113 2014; 14 2014; 18 2012; 22 2009; 15 2016; 46 2014; 203 2016; 151 2016; 150 2012; 62 2009; 249 2015; 6 2015; 5 2006; 12 2002; 6 2013; 42 2008; 15 2016; 95 2008; 97 2014; 110 1998; 133 2014; 155 2015; 7 2016; 14 2009; 137 2011; 331 2011; 254 2014; 44 2002; 26 2016; 7 2013; 39 2017; 92 2011; 91 2015; 62 2015; 65 2015; 21 2016; 65 2009; 9 2016; 62 2017; 143 2005; 11 2014; 34 2010; 52 2016; 9 2016; 22 e_1_2_9_31_1 e_1_2_9_50_1 e_1_2_9_73_1 e_1_2_9_10_1 e_1_2_9_35_1 e_1_2_9_56_1 Huang LF (e_1_2_9_43_1) 2016; 7 e_1_2_9_12_1 e_1_2_9_33_1 e_1_2_9_54_1 e_1_2_9_71_1 Tang YH (e_1_2_9_69_1) 2012; 59 e_1_2_9_14_1 e_1_2_9_16_1 e_1_2_9_37_1 e_1_2_9_58_1 e_1_2_9_18_1 e_1_2_9_64_1 e_1_2_9_20_1 e_1_2_9_62_1 e_1_2_9_22_1 e_1_2_9_45_1 e_1_2_9_68_1 e_1_2_9_24_1 e_1_2_9_66_1 e_1_2_9_8_1 e_1_2_9_6_1 e_1_2_9_4_1 e_1_2_9_60_1 e_1_2_9_2_1 e_1_2_9_26_1 e_1_2_9_49_1 e_1_2_9_28_1 e_1_2_9_47_1 e_1_2_9_30_1 e_1_2_9_53_1 e_1_2_9_51_1 Yu YQ (e_1_2_9_52_1) 2016; 7 e_1_2_9_72_1 e_1_2_9_11_1 e_1_2_9_57_1 e_1_2_9_13_1 e_1_2_9_32_1 e_1_2_9_55_1 e_1_2_9_70_1 e_1_2_9_15_1 e_1_2_9_38_1 e_1_2_9_17_1 e_1_2_9_36_1 e_1_2_9_59_1 e_1_2_9_19_1 e_1_2_9_42_1 e_1_2_9_63_1 e_1_2_9_40_1 e_1_2_9_61_1 e_1_2_9_21_1 e_1_2_9_46_1 e_1_2_9_67_1 e_1_2_9_23_1 e_1_2_9_44_1 e_1_2_9_7_1 Zhu GQ (e_1_2_9_34_1) 2015; 6 Wu J (e_1_2_9_41_1) 2014; 127 e_1_2_9_5_1 Chen K (e_1_2_9_65_1) 2013; 8 e_1_2_9_3_1 Xu L (e_1_2_9_39_1) 2015; 5 e_1_2_9_9_1 e_1_2_9_25_1 e_1_2_9_27_1 e_1_2_9_48_1 e_1_2_9_29_1
References_xml	– volume: 60 start-page: 1165 year: 2014 end-page: 1171 article-title: Is resectable hepatocellular carcinoma a contraindication to liver transplantation? A novel decision model based on “number of patients needed to transplant” as measure of transplant benefit publication-title: J. Hepatol. – volume: 254 start-page: 108 year: 2011 end-page: 113 article-title: Microvascular invasion is a better predictor of tumor recurrence and overall survival following surgical resection for hepatocellular carcinoma compared to the Milan criteria publication-title: Ann. Surg. – volume: 7 start-page: 40 year: 2015 end-page: 43 article-title: Review of preoperative transarterial chemoembolization for resectable hepatocellular carcinoma publication-title: World J. Hepatol. – volume: 65 start-page: 938 year: 2016 end-page: 943 article-title: Survival benefit of liver resection for hepatocellular carcinoma associated with portal vein invasion publication-title: J. Hepatol. – volume: 62 start-page: 848 year: 2015 end-page: 854 article-title: Performance of PIVKA‐II for early hepatocellular carcinoma diagnosis and prediction of microvascular invasion publication-title: J. Hepatol. – volume: 29 start-page: 2014 year: 2014 end-page: 2020 article-title: Artificial neural networking model for the prediction of post‐hepatectomy survival of patients with early hepatocellular carcinoma publication-title: J. Gastroenterol. Hepatol. – volume: 52 start-page: 880 year: 2010 end-page: 888 article-title: Preoperative prediction of hepatocellular carcinoma tumour grade and micro‐vascular invasion by means of artificial neural network: a pilot study publication-title: J. Hepatol. – volume: 39 start-page: 858 year: 2013 end-page: 864 article-title: Preoperative predictors of microvascular invasion in multinodular hepatocellular carcinoma publication-title: Eur. J. Surg. Oncol. – volume: 110 start-page: 1110 year: 2014 end-page: 1117 article-title: A nomogram predicting pulmonary metastasis of hepatocellular carcinoma following partial hepatectomy publication-title: Br. J. Cancer – volume: 15 start-page: 1375 year: 2008 end-page: 1382 article-title: Microvascular invasion in patients with hepatocellular carcinoma and its predictable clinicopathological factors publication-title: Ann. Surg. Oncol. – volume: 92 start-page: 40 year: 2017 end-page: 49 article-title: Immunological microenvironment of hepatocellular carcinoma and its clinical implication publication-title: Oncology – volume: 32 start-page: 594 year: 2006 end-page: 606 article-title: Treatment outcomes for hepatocellular carcinoma using chemoembolization in combination with other therapies publication-title: Cancer Treat. Rev. – volume: 12 start-page: 896 year: 2006 end-page: 898 article-title: Living donor liver transplantation for hepatocellular carcinoma exceeding conventional criteria: questions, answers and demands for a common language publication-title: Liver Transpl. – volume: 91 start-page: 2378 year: 2001 end-page: 2385 article-title: Adjuvant chemotherapy after resection of hepatocellular carcinoma causes deterioration of long‐term prognosis in cirrhotic patients: meta‐analysis of three randomized controlled trials publication-title: Cancer – volume: 148 start-page: 1383 year: 2015 end-page: 1391 article-title: Adjuvant immunotherapy with autologous cytokine‐induced killer cells for hepatocellular carcinoma publication-title: Gastroenterology – volume: 249 start-page: 195 year: 2009 end-page: 202 article-title: A prospective, randomized, controlled trial of preoperative transarterial chemoembolization for resectable large hepatocellular carcinoma publication-title: Ann. Surg. – volume: 6 start-page: 18151 year: 2015 end-page: 18161 article-title: Optimal adjuvant therapy for resected hepatocellular carcinoma: a systematic review with network meta‐analysis publication-title: Oncotarget – volume: 91 start-page: 1279 year: 2011 end-page: 1285 article-title: Analysis of factors affecting recurrence of hepatocellular carcinoma after liver transplantation with a special focus on inflammation markers publication-title: Transplantation – volume: 56 start-page: 267 year: 2012 end-page: 275 article-title: Molecular diagnosis and therapy of hepatocellular carcinoma (HCC): an emerging field for advanced technologies publication-title: J. Hepatol. – volume: 55 start-page: 1325 year: 2011 end-page: 1331 article-title: Gene‐expression signature of vascular invasion in hepatocellular carcinoma publication-title: J. Hepatol. – volume: 7 start-page: 16362 year: 2016 end-page: 16371 article-title: Identification of serologic biomarkers for predicting microvascular invasion in hepatocellular carcinoma publication-title: Oncotarget – volume: 9 start-page: 285 year: 2009 end-page: 293 article-title: The metastatic niche: adapting the foreign soil publication-title: Nat. Rev. Cancer – volume: 20 start-page: 4305 year: 2013 end-page: 4311 article-title: The efficacy of cytokine‐induced killer cell infusion as an adjuvant therapy for postoperative hepatocellular carcinoma patients publication-title: Ann. Surg. Oncol. – volume: 127 start-page: 430 year: 2014 end-page: 434 article-title: A single center experience: post‐transplantation adjuvant chemotherapy impacts the prognosis of hepatocellular carcinoma patients publication-title: Chin. Med. J. – volume: 20 start-page: 325 year: 2013 end-page: 339 article-title: A systematic review of microvascular invasion in hepatocellular carcinoma: diagnostic and prognostic variability publication-title: Ann. Surg. Oncol. – volume: 137 start-page: 850 year: 2009 end-page: 855 article-title: A system of classifying microvascular invasion to predict outcome after resection in patients with hepatocellular carcinoma publication-title: Gastroenterology – volume: 95 start-page: e2665 year: 2016 article-title: Adjuvant cytokine‐induced killer cell therapy improves disease‐free and overall survival in solitary and nonmicrovascular invasive hepatocellular carcinoma after curative resection publication-title: Medicine (Baltimore) – volume: 102 start-page: 462 year: 2010 end-page: 468 article-title: Predictors of microvascular invasion before hepatectomy for hepatocellular carcinoma publication-title: J. Surg. Oncol. – volume: 150 start-page: 835 year: 2016 end-page: 853 article-title: Evidence‐based diagnosis, staging, and treatment of patients with hepatocellular carcinoma publication-title: Gastroenterology – volume: 12 start-page: 56 year: 2010 end-page: 61 article-title: Alpha‐fetoprotein and tumour size are associated with microvascular invasion in explanted livers of patients undergoing transplantation with hepatocellular carcinoma publication-title: HPB (Oxford) – volume: 21 start-page: 4627 year: 2015 end-page: 4634 article-title: Adjuvant transarterial chemoembolization after curative resection of hepatocellular carcinoma: propensity score analysis publication-title: World J. Gastroenterol. – volume: 17 start-page: 1218 year: 2011 end-page: 1225 article-title: Can positron emission tomography with the dual tracers [ C]acetate and [ F]fludeoxyglucose predict microvascular invasion in hepatocellular carcinoma? publication-title: Liver Transpl. – volume: 62 start-page: 394 year: 2012 end-page: 399 article-title: Recent progress in understanding, diagnosing, and treating hepatocellular carcinoma publication-title: CA Cancer J. Clin. – volume: 18 start-page: 1994 year: 2014 end-page: 2002 article-title: Anatomic versus nonanatomic hepatectomy for a solitary hepatocellular carcinoma: a case‐controlled study with propensity score matching publication-title: J. Gastrointest. Surg. – volume: 29 start-page: 330 year: 2014 end-page: 336 article-title: Microvascular invasion in small hepatocellular carcinoma: is it predictable with preoperative diffusion‐weighted imaging? publication-title: J. Gastroenterol. Hepatol. – volume: 5 year: 2015 article-title: A randomized controlled trial on patients with or without adjuvant autologous cytokine‐induced killer cells after curative resection for hepatocellular carcinoma publication-title: Oncoimmunology – volume: 8 year: 2013 article-title: Adjuvant iodine‐125 brachytherapy for hepatocellular carcinoma after complete hepatectomy: a randomized controlled trial publication-title: PLoS One – volume: 203 start-page: W253 year: 2014 end-page: W259 article-title: Prediction of microvascular invasion of hepatocellular carcinoma: preoperative CT and histopathologic correlation publication-title: AJR Am. J. Roentgenol. – volume: 133 start-page: 183 year: 1998 end-page: 188 article-title: Postoperative adjuvant chemotherapy after curative resection of hepatocellular carcinoma: a randomized controlled trial publication-title: Arch. Surg. – volume: 15 start-page: 574 year: 2009 end-page: 580 article-title: Improved results of transplantation for hepatocellular carcinoma: a report from the international registry of hepatic tumors in liver transplantation publication-title: Liver Transpl. – volume: 15 start-page: 972 year: 2008 end-page: 978 article-title: Early hepatocellular carcinoma: pathology, imaging, and therapy publication-title: Ann. Surg. Oncol. – volume: 22 start-page: 9279 year: 2016 end-page: 9287 article-title: Practice guidelines for the pathological diagnosis of primary liver cancer: 2015 update publication-title: World J. Gastroenterol. – volume: 331 start-page: 1559 year: 2011 end-page: 1564 article-title: A perspective on cancer cell metastasis publication-title: Science – volume: 14 start-page: 38 year: 2014 article-title: Microvascular invasion (MVI) is a poorer prognostic predictor for small hepatocellular carcinoma publication-title: BMC Cancer – volume: 62 start-page: 86 year: 2016 end-page: 95 article-title: Nomograms for survival prediction in patients undergoing liver resection for hepatitis B virus related early stage hepatocellular carcinoma publication-title: Eur. J. Cancer – volume: 65 start-page: 87 year: 2015 end-page: 108 article-title: Global cancer statistics, 2012 publication-title: CA Cancer J. Clin. – volume: 26 start-page: 25 year: 2002 end-page: 34 article-title: Prognostic histologic indicators of curatively resected hepatocellular carcinomas: a multi‐institutional analysis of 425 patients with definition of a histologic prognostic index publication-title: Am. J. Surg. Pathol. – volume: 11 start-page: 1086 year: 2005 end-page: 1092 article-title: Tumor size predicts vascular invasion and histologic grade: implications for selection of surgical treatment for hepatocellular carcinoma publication-title: Liver Transpl. – volume: 155 start-page: 512 year: 2014 end-page: 521 article-title: Anatomic versus nonanatomic resection in cirrhotic patients with early hepatocellular carcinoma publication-title: Surgery – volume: 14 start-page: 100 year: 2016 article-title: Clinical efficacy of postoperative adjuvant transcatheter arterial chemoembolization on hepatocellular carcinoma publication-title: World J. Surg. Oncol. – volume: 19 start-page: 2027 year: 2012 end-page: 2034 article-title: Predictors for microinvasion of small hepatocellular carcinoma ≤2 cm publication-title: Ann. Surg. Oncol. – volume: 10 start-page: 35 year: 2009 end-page: 43 article-title: Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis publication-title: Lancet Oncol. – volume: 44 start-page: 523 year: 2014 end-page: 531 article-title: Efficacy of sorafenib as adjuvant therapy to prevent early recurrence of hepatocellular carcinoma after curative surgery: a pilot study publication-title: Hepatol. Res. – volume: 6 start-page: 224 year: 2002 end-page: 232 article-title: Predictors of microvascular invasion in patients with hepatocellular carcinoma who are candidates for orthotopic liver transplantation publication-title: J. Gastrointest. Surg. – volume: 62 start-page: 792 year: 2015 end-page: 800 article-title: A computed tomography radiogenomic biomarker predicts microvascular invasion and clinical outcomes in hepatocellular carcinoma publication-title: Hepatology – volume: 115 start-page: 4753 year: 2009 end-page: 4765 article-title: Liver–intestine cadherin predicts microvascular invasion and poor prognosis of hepatitis B virus‐positive hepatocellular carcinoma publication-title: Cancer – volume: 7 start-page: 25493 year: 2016 end-page: 25506 article-title: A novel scoring system predicts adjuvant chemolipiodolization benefit for hepatocellular carcinoma patients after hepatectomy publication-title: Oncotarget – volume: 113 start-page: 296 year: 2016 end-page: 303 article-title: The importance of surgical margins in primary malignancies of the liver publication-title: J. Surg. Oncol. – volume: 28 start-page: 1063 year: 2010 end-page: 1069 article-title: Obesity and microvascular invasion in hepatocellular carcinoma publication-title: Cancer Investig. – volume: 396 start-page: 1109 year: 2011 end-page: 1117 article-title: Meta‐analysis of anatomic resection versus nonanatomic resection for hepatocellular carcinoma publication-title: Langenbeck's Arch. Surg. – volume: 42 start-page: 151 year: 2013 end-page: 160 article-title: Effect of transcatheter arterial chemoembolization prior to surgical resection for hepatocellular carcinoma publication-title: Int. J. Oncol. – volume: 34 start-page: 363 year: 2014 end-page: 375 article-title: Molecular profiling of liver tumors: classification and clinical translation for decision making publication-title: Semin. Liver Dis. – volume: 59 start-page: 1393 year: 2012 end-page: 1397 article-title: Resection margin in hepatectomy for hepatocellular carcinoma: a systematic review publication-title: Hepato‐Gastroenterology – volume: 263 start-page: 1112 year: 2016 end-page: 1125 article-title: A review and update of treatment options and controversies in the management of hepatocellular carcinoma publication-title: Ann. Surg. – volume: 22 start-page: 291 year: 2012 end-page: 303 article-title: TGF‐β‐miR‐34a‐CCL22 signaling‐induced Treg cell recruitment promotes venous metastases of HBV‐positive hepatocellular carcinoma publication-title: Cancer Cell – volume: 143 start-page: 293 year: 2017 end-page: 303 article-title: Novel microvascular invasion‐based prognostic nomograms to predict survival outcomes in patients after R0 resection for hepatocellular carcinoma publication-title: J. Cancer Res. Clin. Oncol. – volume: 97 start-page: 246 year: 2008 end-page: 252 article-title: Prediction of microvascular invasion before curative resection of hepatocellular carcinoma publication-title: J. Surg. Oncol. – volume: 9 start-page: 167 year: 2016 end-page: 172 article-title: A preoperative measurement of serum microRNA‐125b may predict the presence of microvascular invasion in hepatocellular carcinomas patients publication-title: Transl. Oncol. – volume: 56 start-page: 2231 year: 2012 end-page: 2241 article-title: Long noncoding RNA associated with microvascular invasion in hepatocellular carcinoma promotes angiogenesis and serves as a predictor for hepatocellular carcinoma patients' poor recurrence‐free survival after hepatectomy publication-title: Hepatology – volume: 46 start-page: 1275 year: 2016 end-page: 1281 article-title: A non‐smooth tumor margin on preoperative imaging predicts microvascular invasion of hepatocellular carcinoma publication-title: Surg. Today – volume: 17 start-page: 963 year: 2012 end-page: 969 article-title: Independent factors and predictive score for extrahepatic metastasis of hepatocellular carcinoma following curative hepatectomy publication-title: Oncologist – volume: 151 start-page: 356 year: 2016 end-page: 363 article-title: Nomogram for preoperative estimation of microvascular invasion risk in hepatitis B virus‐related hepatocellular carcinoma within the Milan criteria publication-title: JAMA Surg. – ident: e_1_2_9_55_1 doi: 10.1111/jgh.12358 – ident: e_1_2_9_31_1 doi: 10.1038/bjc.2014.19 – ident: e_1_2_9_42_1 doi: 10.1111/hepr.12159 – ident: e_1_2_9_73_1 doi: 10.4254/wjh.v7.i1.40 – ident: e_1_2_9_6_1 doi: 10.1016/j.jhep.2016.05.044 – ident: e_1_2_9_4_1 doi: 10.3322/caac.21161 – ident: e_1_2_9_9_1 doi: 10.1053/j.gastro.2009.06.003 – ident: e_1_2_9_33_1 doi: 10.1002/1097-0142(20010615)91:12<2378::AID-CNCR1271>3.0.CO;2-2 – ident: e_1_2_9_49_1 doi: 10.1002/jso.21631 – ident: e_1_2_9_61_1 doi: 10.1016/j.ejso.2013.04.003 – ident: e_1_2_9_51_1 doi: 10.1016/j.jhep.2014.11.005 – ident: e_1_2_9_64_1 doi: 10.1016/j.jhep.2014.01.022 – ident: e_1_2_9_17_1 doi: 10.1126/science.1203543 – ident: e_1_2_9_8_1 doi: 10.1245/s10434-008-9846-9 – ident: e_1_2_9_32_1 doi: 10.1001/archsurg.133.2.183 – ident: e_1_2_9_2_1 doi: 10.3322/caac.21262 – ident: e_1_2_9_40_1 doi: 10.1053/j.gastro.2015.02.055 – ident: e_1_2_9_18_1 doi: 10.1016/j.jhep.2011.07.007 – ident: e_1_2_9_35_1 doi: 10.1016/j.ctrv.2006.08.002 – ident: e_1_2_9_29_1 doi: 10.1111/jgh.12672 – ident: e_1_2_9_56_1 doi: 10.1002/lt.22362 – ident: e_1_2_9_59_1 doi: 10.1016/j.jhep.2009.12.037 – ident: e_1_2_9_30_1 doi: 10.1634/theoncologist.2011-0447 – ident: e_1_2_9_57_1 doi: 10.1016/j.jhep.2011.02.034 – ident: e_1_2_9_48_1 doi: 10.1007/s00595-016-1320-x – ident: e_1_2_9_21_1 doi: 10.1159/000451015 – ident: e_1_2_9_22_1 doi: 10.1016/j.ccr.2012.07.023 – ident: e_1_2_9_13_1 doi: 10.1002/lt.20472 – volume: 127 start-page: 430 year: 2014 ident: e_1_2_9_41_1 article-title: A single center experience: post‐transplantation adjuvant chemotherapy impacts the prognosis of hepatocellular carcinoma patients publication-title: Chin. Med. J. doi: 10.3760/cma.j.issn.0366-6999.20120126 – volume: 8 year: 2013 ident: e_1_2_9_65_1 article-title: Adjuvant iodine‐125 brachytherapy for hepatocellular carcinoma after complete hepatectomy: a randomized controlled trial publication-title: PLoS One – ident: e_1_2_9_16_1 doi: 10.1038/nrc2621 – ident: e_1_2_9_3_1 doi: 10.1053/j.gastro.2015.12.041 – ident: e_1_2_9_19_1 doi: 10.1055/s-0034-1394137 – ident: e_1_2_9_27_1 doi: 10.1097/TP.0b013e3182187cf0 – ident: e_1_2_9_11_1 doi: 10.1007/s00432-016-2286-1 – ident: e_1_2_9_45_1 doi: 10.1111/j.1477-2574.2009.00128.x – ident: e_1_2_9_67_1 doi: 10.1007/s00423-011-0784-9 – ident: e_1_2_9_71_1 doi: 10.1002/lt.20808 – ident: e_1_2_9_23_1 doi: 10.1097/SLA.0b013e31821ad884 – ident: e_1_2_9_72_1 doi: 10.1097/SLA.0b013e3181961c16 – ident: e_1_2_9_20_1 doi: 10.1002/hep.25895 – ident: e_1_2_9_47_1 doi: 10.1002/jso.20953 – ident: e_1_2_9_62_1 doi: 10.1016/j.surg.2013.10.009 – ident: e_1_2_9_53_1 doi: 10.2214/AJR.13.10595 – ident: e_1_2_9_63_1 doi: 10.1016/j.tranon.2016.03.002 – ident: e_1_2_9_28_1 doi: 10.1016/j.ejca.2016.04.011 – volume: 6 start-page: 18151 year: 2015 ident: e_1_2_9_34_1 article-title: Optimal adjuvant therapy for resected hepatocellular carcinoma: a systematic review with network meta‐analysis publication-title: Oncotarget doi: 10.18632/oncotarget.4098 – ident: e_1_2_9_66_1 doi: 10.3892/ijo.2012.1711 – ident: e_1_2_9_37_1 doi: 10.1186/s12957-016-0855-z – volume: 5 year: 2015 ident: e_1_2_9_39_1 article-title: A randomized controlled trial on patients with or without adjuvant autologous cytokine‐induced killer cells after curative resection for hepatocellular carcinoma publication-title: Oncoimmunology – ident: e_1_2_9_60_1 doi: 10.1001/jamasurg.2015.4257 – ident: e_1_2_9_50_1 doi: 10.3109/07357907.2010.483500 – ident: e_1_2_9_10_1 doi: 10.3748/wjg.v22.i42.9279 – ident: e_1_2_9_44_1 doi: 10.1097/MD.0000000000002665 – ident: e_1_2_9_46_1 doi: 10.1016/S1091-255X(01)00015-4 – ident: e_1_2_9_5_1 doi: 10.1097/SLA.0000000000001556 – ident: e_1_2_9_68_1 doi: 10.1007/s11605-014-2646-6 – ident: e_1_2_9_25_1 doi: 10.1245/s10434-011-2195-0 – ident: e_1_2_9_26_1 doi: 10.1016/S1470-2045(08)70284-5 – ident: e_1_2_9_14_1 doi: 10.1186/1471-2407-14-38 – ident: e_1_2_9_70_1 doi: 10.1002/jso.24123 – ident: e_1_2_9_24_1 doi: 10.1245/s10434-007-9685-0 – ident: e_1_2_9_15_1 doi: 10.1002/lt.21738 – ident: e_1_2_9_36_1 doi: 10.3748/wjg.v21.i15.4627 – ident: e_1_2_9_7_1 doi: 10.1245/s10434-012-2513-1 – ident: e_1_2_9_58_1 doi: 10.1002/cncr.24513 – ident: e_1_2_9_38_1 doi: 10.1245/s10434-013-3144-x – ident: e_1_2_9_54_1 doi: 10.1002/hep.27877 – ident: e_1_2_9_12_1 doi: 10.1097/00000478-200201000-00003 – volume: 59 start-page: 1393 year: 2012 ident: e_1_2_9_69_1 article-title: Resection margin in hepatectomy for hepatocellular carcinoma: a systematic review publication-title: Hepato‐Gastroenterology – volume: 7 start-page: 16362 year: 2016 ident: e_1_2_9_52_1 article-title: Identification of serologic biomarkers for predicting microvascular invasion in hepatocellular carcinoma publication-title: Oncotarget doi: 10.18632/oncotarget.7649 – volume: 7 start-page: 25493 year: 2016 ident: e_1_2_9_43_1 article-title: A novel scoring system predicts adjuvant chemolipiodolization benefit for hepatocellular carcinoma patients after hepatectomy publication-title: Oncotarget doi: 10.18632/oncotarget.8333
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Snippet	Partial hepatectomy and liver transplantation are potentially curative treatments in selected patients with hepatocellular carcinoma (HCC). Unfortunately, a...
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SubjectTerms	Carcinoma, Hepatocellular - blood supply Carcinoma, Hepatocellular - diagnostic imaging Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - surgery Decision making Hepatectomy Hepatocellular carcinoma Humans Liver cancer Liver Neoplasms - blood supply Liver Neoplasms - diagnostic imaging Liver Neoplasms - pathology Liver Neoplasms - surgery liver resection Liver Transplantation Medical prognosis Metastases microvascular invasion Microvasculature Microvessels - pathology Neoplasm Invasiveness prediction Transplantation
Title	Significance of presence of microvascular invasion in specimens obtained after surgical treatment of hepatocellular carcinoma
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